1093070-14-4|PLpro inhibitor|PLpro inhibitor|No data available-范德生物科技公司

PLpro inhibitor

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names：
PLpro inhibitor
CAS号：
1093070-14-4
MDL Number： No data available
MF(分子式)： C22H22N2O2 MW(分子量)： 346.42
EINECS:No data available Reaxys Number:No data available
Pubchem ID:312811351 Brand:BIOFOUNT

PLpro inhibitor(1093070-14-4)是一种有效的木瓜蛋白酶样蛋白酶（PLpro）抑制剂，PLpro抑制剂具有显着的抗病毒活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000881-5mg	5mg	99.7%	¥ 3295.00	¥ 3295.00		2-3天	- +	¥ 0.00
YZM000881-2mg	2mg	99.7%	¥ 2116.00	¥ 2116.00		2-3天	- +	¥ 0.00

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中文别名	PLpro inhibitor(1093070-14-4),5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺,PLpro抑制剂
英文别名	PLpro inhibitor,1093070-14-4
CAS号	1093070-14-4
SMILES	O=C(C1=CC(NC(C)=O)=CC=C1C)N[C@H](C)C2=C(C=CC=C3)C3=CC=C2
Inchi	InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1
InchiKey	KGPYBLOBHQLIET-OAHLLOKOSA-N
分子式 Formula	C22H22N2O2
分子量 Molecular Weight	346.42
闪点 FP	199.4±30.3 °C
熔点 Melting point	No data available
沸点 Boiling point	584.7±50.0 °C at 760 mmHg
Polarizability极化度	42.0±0.5 10-24cm3
密度 Density	1.2±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.6 mmHg at 25°C
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 42 mg/mL(121.24 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	白色至灰白色固体粉末
储藏条件 Storage conditions	在-20°C条件下保存3年,在4°C条件下保存2年

PLpro inhibitor(1093070-14-4)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

PLpro inhibitor(1093070-14-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:PLpro inhibitor(1093070-14-4),PLpro inhibitor的作用,PLpro抑制剂,PLpro inhibitor的效果,PLpro inhibitor的使用,PLpro inhibitor的合成,PLpro inhibitor的生产,PLpro inhibitor的外观,PLpro inhibitor的溶解度,PLpro inhibitor的MSDS

产品说明	PLpro inhibitor(1093070-14-4)是一种有效的木瓜蛋白酶样蛋白酶（PLpro）抑制剂，PLpro抑制剂具有显着的抗病毒活性。
Introduction	PLpro inhibitor (1093070-14-4) is a potent papain-like protease (PLpro) inhibitor, PLpro inhibitor has significant antiviral activity.
Application1
Application2
Application3

PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells.

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
Lee H1, Lei H1, Santarsiero BD1, Gatuz JL1, Cao S1, Rice AJ1, Patel K1, Szypulinski MZ1, Ojeda I, Ghosh AK2, Johnson ME1. ACS Chem Biol. 2015 Jun 19;10(6):1456-65. doi: 10.1021/cb500917m. Epub 2015 Mar 16.
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease (PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro, where it has been proven to play a crucial role in SARS-CoV PLpro inhibitor binding. Four SARS-CoV PLpro lead inhibitors were tested against MERS-CoV PLpro, none of which were effective against MERS-CoV PLpro. Structure and sequence alignments revealed that two residues, Y269 and Q270, responsible for inhibitor binding to SARS-CoV PLpro, were replaced by T274 and A275 in MERS-CoV PLpro, making critical binding interactions difficult to form for similar types of inhibitors. High-throughput screening (HTS) of 25?000 compounds against both PLpro enzymes identified a small fragment-like noncovalent dual inhibitor. Mode of inhibition studies by enzyme kinetics and competition surface plasmon resonance (SPR) analyses suggested that this compound acts as a competitive inhibitor with an IC50 of 6 μM against MERS-CoV PLpro, indicating that it binds to the active site, whereas it acts as an allosteric inhibitor against SARS-CoV PLpro with an IC50 of 11 μM.

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