140926-75-6|NSC5844|NSC5844|-范德生物科技公司

NSC5844

NMR下载 COA and HPLC MSDS下载
names：
NSC5844
CAS号：
140926-75-6
MDL Number：
MF(分子式)： C20H16Cl2N4 MW(分子量)： 383.27
EINECS: Reaxys Number:
Pubchem ID:221354 Brand:BIOFOUNT

NSC5844(140926-75-6)是一种双喹啉化合物，NSC5844也是一种CCR1激动剂，NSC5844具有抗肿瘤和抗疟疾活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	库存描述	数量	总计 (¥)
FMK23156-200mg	200mg	>98%	¥ 9100.00	¥ 9100.00	2 Weeks	- +	¥ 0.00
FMK23156-100mg	100mg	>98%	¥ 4900.00	¥ 4900.00	2 Weeks	- +	¥ 0.00
HCR227960-10mg	10mg	98%	¥ 1530.00	¥ 1530.00	4-7周	- +	¥ 0.00

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中文别名	NSC5844(140926-75-6);NSC5844 (RE640);NSC 5844; NSC-5844; RE 640; RE-640; RE640
英文别名	NSC5844
CAS号	140926-75-6
SMILES	C1=CC2=C(C=CN=C2C=C1Cl)NCCNC3=C4C=CC(=CC4=NC=C3)Cl
Inchi	InChI=1S/C20H16Cl2N4/c21-13-1-3-15-17(5-7-23-19(15)11-13)25-9-10-26-18-6-8-24-20-12-14(22)2-4-16(18)20/h1-8,11-12H,9-10H2,(H,23,25)(H,24,26)
InchiKey	SSXYXSMMVMVYEV-UHFFFAOYSA-N
分子式 Formula	C20H16Cl2N4
分子量 Molecular Weight	383.27
闪点 FP	336.4±31.5 °C
熔点 Melting point	Not available
沸点 Boiling point	632.6±55.0 °C at 760 mmHg
Polarizability极化度	44.1±0.5 10-24cm3
密度 Density	1.4±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.9 mmHg at 25°C
溶解度Solubility
性状	白色至灰白色固体粉末
储藏条件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

NSC5844(140926-75-6)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。

NSC5844(140926-75-6) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
3776. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:NSC5844(140926-75-6),NSC5844试剂,NSC5844的纯度,NSC5844的作用,NSC5844的外观,NSC5844的含量,NSC5844合成,NSC5844的生产,NSC5844的厂家,NSC5844的价格,NSC5844激动剂,NSC5844的使用

产品说明	NSC5844(140926-75-6)可以作为药物杂质对照品以及生物医药类试剂。
Introduction	NSC5844(140926-75-6) can be used as a reference substance for drug impurities and reagents，only for research.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine实验过程中防止吸入、食入，做好安全防护

Zhang H, et al. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed Pharmacother. 2008 Feb;62(2):65-9. Epub 2007 May 24.

Vennerstrom JL, et al. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29;35(11):2129-34.

Potent adjuvantic activity of a CCR1-agonistic bis-quinoline

[Adrenergic and cholinergic control of oxytocin release evoked by vaginal, vagal and mammary stimulation in lactating rats (author's transl)]

Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
Abstract:A series of 4-aminoquinoline derivatives were synthesized by the reaction of 4-chloro-7-substituted-quinolines with the corresponding mono/dialkyl amines. The structures of the synthesized compounds were confirmed by NMR and FAB-MS spectral and elemental analyses. Subsequently, the compounds were examined for their cytotoxic effects on two different human breast tumor cell lines: MCF7 and MDA-MB468. Although all compounds examined were quite effective on both cell lines, the compound N'-(7-chloro-quinolin-4-yl)-N,N-dimethyl-ethane-1,2-diamine emerged as the most active compound of the series. It was particularly potent against MDA-MB 468 cells when compared to chloroquine and amodiaquine. The compound butyl-(7-fluoro-quinolin-4-yl)-amine showed more potent effects on MCF-7 cells when compared to chloroquine. Therefore, 4-aminoquinoline can serve as the prototype molecule for further development of a new class of anticancer agents.

Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria
Abstract:On the basis of observations that several bisquinolines such as piperaquine possess notable activity against chloroquine-resistant malaria, 13 N,N-bis-(7-chloroquinolin-4-yl)alkanediamines were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. Twelve of the thirteen bisquinolines had a significantly lower resistance index than did chloroquine; the resistance index was apparently unrelated to either in vitro or in vivo activity. Except for two compounds, there was a reasonable correlation between in vitro and in vivo activities. Seven of the thirteen bisquinolines had IC50's of less than 6 nM against both chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum and were curative against P. berghei at doses of 640 mg/kg. In contrast to chloroquine, these bisquinolines did not show any toxic deaths at curative dose levels. Four bisquinolines, however, caused skin lesions at the site of injection. Maximum activity was seen in bisquinolines with a connecting bridge of two carbon atoms where decreased conformational mobility seemed to increase activity. Bisquinoline 3 (+/-)-trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamin e was not only the most potent bisquinoline in vitro, but was clearly unique in its in vivo activity--80% and 100% cure rates were achieved at doses of 160 and 320 mg/kg, respectively. In summary, these preliminary results support the premise that bisquinolines may be useful agents against chloroquine-resistant malaria.

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