443639-96-1|S119-8|S119-8|MFCD01121291-范德生物科技公司

S119-8

NMR下载 COA and HPLC MSDS下载
names：
S119-8
CAS号：
443639-96-1
MDL Number： MFCD01121291
MF(分子式)： C23H24N2O MW(分子量)： 344.45
EINECS: Reaxys Number:
Pubchem ID:1787280 Brand:BIOFOUNT

S119-8(443639-96-1)是A型和B型流感病毒的广谱抑制剂。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000736-10mg	10mg	99.49%	¥ 2430.00	¥ 2430.00		2-3天	- +	¥ 0.00
YZM000736-5mg	5mg	99.49%	¥ 1462.50	¥ 1462.50		2-3天	- +	¥ 0.00

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	S119-8(443639-96-1);N-（4-苯胺基苯基）-4-叔丁基苯甲酰胺;4-（叔丁基）-N-（4-（苯基氨基）苯基）苯甲酰胺;
英文别名	S119-8(443639-96-1);N-(4-anilinophenyl)-4-tert-butylbenzamide;4-(tert-Butyl)-N-(4-(phenylamino)phenyl)benzamide;
CAS号	443639-96-1
SMILES	O=C(NC1=CC=C(NC2=CC=CC=C2)C=C1)C3=CC=C(C(C)(C)C)C=C3
Inchi	InChI = 1S / C23H24N2O / c1-23（2,3）18-11-9-17（10-12-18）22（26）25-21-15-13-20（14-16-21）24- 19-7-5-4-6-8-19 / h4-16,24H，1-3H3，（H，25,26）
InchiKey	NEPKMQDGCTXOPG-UHFFFAOYSA-N
分子式 Formula	C23H24N2O
分子量 Molecular Weight	344.45
闪点 FP	128.3±26.9°摄氏度
熔点 Melting point	No data available
沸点 Boiling point	760毫米汞柱时为447.3±38.0°C
Polarizability极化度
密度 Density	1.1±0.1克/厘米3
蒸汽压 Vapor Pressure	25°C时为0.0±1.1 mmHg
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 150 mg/mL(435.48 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	白色至米色粉末 ,Power
储藏条件 Storage conditions	2-8°C,-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

S119-8(443639-96-1)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:S119-8试剂,S119-8杂质,S119-8中间体,S119-8密度,S119-8合成,S119-8溶解度,S119-8旋光度,S119-8闪点,S119-8购买,S119-8MSDS,

产品说明	S119-8(443639-96-1)是A型和B型流感病毒的广谱抑制剂。
Introduction	S119-8(443639-96-1)is a broad spectrum inhibitor of influenza AandB viruses.
Application1
Application2
Application3

S119-8(443639-96-1)药理学：

1、S119-8(443639-96-1)是A型和B型流感病毒的广谱抑制剂。

2、S119-8是S119的类似物。S119-8获得了增强的广谱活性，具有改进的计算物理性能，同时保持了显着的效能（IC₅₀= 1.43μM）（无毒（CC）₅₀= 66.10μM）浓度，尽管它比针对流感A / WSN / 33 H1N1（WSN）病毒的亲本S119浓度要高（7倍）。S119-8还显示出对多种乙型流感病毒和耐奥司他韦的甲型流感病毒的活性，但不抑制非流感病毒水疱性口炎（VSV）。S119-8增强了对甲型和乙型流感病毒的抑制广度，但效力却仅有很小的损失。S119-8通过IC抑制流感病毒A /波多黎各/ 8/1934（H1N1）（PR8）₅₀为6.05μM。S119-8通过IC抑制甲型流感/越南/ 1203/2004（H5N1）₅₀ 为8.42μM。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.

S119-8(443639-96-1)参考文献：

1、Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein
Kris M White 1, Pablo Abreu Jr 1, Hui Wang, Paul D De Jesus, Balaji Manicassamy 1, Adolfo García-Sastre 1, Sumit K Chanda, Robert J DeVita, Megan L Shaw

Abstract S119 was a top hit from an ultrahigh throughput screen performed to identify novel inhibitors of influenza virus replication. It showed a potent antiviral effect (50% inhibitory concentration, IC50 = 20 nM) and no detectable cytotoxicity (50% cytotoxic concentration, CC50 > 500 μM) to yield a selectivity index greater than 25 000. Upon investigation, we found that S119 selected for resistant viruses carrying mutations in the viral nucleoprotein (NP). These resistance mutations highlight a likely S119 binding site overlapping with but not identical to that found for the compound nucleozin. Mechanism of action studies revealed that S119 affects both the oligomerization state and cellular localization of the NP protein which has an impact on viral transcription, replication, and protein expression. Through a hit-to-lead structure-activity relationship (SAR) study, we found an analog of S119, named S119-8, which had increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. Finally, in vitro viral inhibition assays showed a synergistic relationship between S119-8 and oseltamivir when they were combined, indicating the potential for future drug cocktails.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开