14919-49-4|3,4′-二羟基黄酮|3,4'-Dihydroxyflavone|MFCD00017690-范德生物科技公司

3,4′-二羟基黄酮

NMR下载 COA and HPLC MSDS下载
names：
3,4'-Dihydroxyflavone
CAS号：
14919-49-4
MDL Number： MFCD00017690
MF(分子式)： C15H10O4 MW(分子量)： 254.24
EINECS: Reaxys Number:
Pubchem ID:688715 Brand:BIOFOUNT

3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)是一种口服活性类黄酮，3,4′-二羟基黄酮对甲型流感病毒具有抗病毒活性。

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YZM000735-200mg	200mg	98.2%	¥ 0.00	¥ 0.00		Backorder	- +	¥ 0.00
YZM000735-100mg	100mg	98.2%	¥ 926.25	¥ 926.25		2-3天	- +	¥ 0.00

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中文别名	3,4′-二羟基黄酮(14919-49-4);3,4'-DHF; 3-羟基-2-（4-羟基苯基）-4H-铬-4-酮; 4'-羟基黄酮醇;
英文别名	3,4'-Dihydroxyflavone(14919-49-4);3,4'-DHF; 3-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 4'-hydroxyflavonol;
CAS号	14919-49-4
SMILES	O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C1C=CC=C3
Inchi	InChI = 1S / C15H10O4 / c16-10-7-5-9（6-8-10）15-14（18）13（17）11-3-1-2-4-12（11）19-15 / h1-8,16,18H
InchiKey	GPGOCTLAUAHUQO-UHFFFAOYSA-N
分子式 Formula	C15H10O4
分子量 Molecular Weight	254.24
闪点 FP	175.7±22.2°摄氏度
熔点 Melting point	275-276°C
沸点 Boiling point	452.5±45.0 °C(Predicted)
Polarizability极化度
密度 Density	1.472±0.06 g/cm3(Predicted)
蒸汽压 Vapor Pressure	25°C时0.0±1.2 mmHg
溶解度Solubility
性状	黄色结晶固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)毒性性质：

3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)是一种有效的具有口服活性的黄酮类有机化合物,具有抗病毒活性
Introduction	3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)is an oral active flavonoid with antiviral activity againstInfluenza A virus.
Application1
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3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)药理学：

3-羟基-2-（4-羟基苯基）-4H-铬-4--4-酮，也称为4-羟基黄酮醇，属于称为黄酮醇的有机化合物。黄酮醇是含有在3-位带有羟基的黄酮（2-苯基-1-苯并吡喃-4-酮）主链的化合物。3-羟基-2-（4-羟基苯基）-4H-色烯-4-酮被认为是实际上不溶的（在水中）并且是相对中性的分子。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)危害标识：

象形图
信号	Warning
GHS危险说明	Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
	H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
	H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
防范说明代码	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Hossain MK, et al. Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus. J Microbiol. 2014 Jun;52(6):521-6.

Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids PMID 16014620; The Journal of biological chemistry 2005 Sep; 280(36):31498-507 Name ma

Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis PMID 32256687; Chinese medicine 2020; 15(?):31 Name matches: isorhamnetin

The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes PMID 17202655; Biological & pharmaceutical bulletin 2007 Jan; 30(1):32-7 Name matches: poly(adp-ribos

3,4′-二羟基黄酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)参考文献：

1.Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus.
Hossain MK1, Choi HY, Hwang JS, Dayem AA, Kim JH, Kim YB, Poo H, Cho SG. J Microbiol. 2014 Jun;52(6):521-6. doi: 10.1007/s12275-014-4212-z. Epub 2014 May 29.

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2?dihydroxyflavone (3,2?DHF) and 3,4?dihydroxyflavone (3,4?DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4?DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4?DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo.

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