114778-60-8|BRL44385|BRL44385|MFCD00871933-范德生物科技公司

BRL44385

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names：
BRL44385
CAS号：
114778-60-8
MDL Number： MFCD00871933
MF(分子式)： C8H11N5O3 MW(分子量)： 225.2
EINECS: Reaxys Number:
Pubchem ID:135409371 Brand:BIOFOUNT

BRL44385(114778-60-8)有效且选择性地抑制单纯疱疹病毒1型和2型（HSV-1和HSV-2），水痘带状疱疹病毒（VZV）和Epstein-Barr病毒（EBV）复制。

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YZM000724-5mg	5mg		¥ 20553.00	¥ 20553.00		Backorder	- +	¥ 0.00
YZM000724-1mg	1mg	>97%	¥ 9945.00	¥ 9945.00		2-3天	- +	¥ 0.00

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中文别名	BRL44385(114778-60-8);9-（3-羟基丙氧基）鸟嘌呤;BRL 44385;BRL-44385;
英文别名	BRL44385(114778-60-8);9-(3-hydroxypropoxy)guanine;BRL 44385;BRL-44385;
CAS号	114778-60-8
SMILES	O=C1N=C(N)NC2=C1N=CN2OCCCO
Inchi	InChI = 1S / C8H11N5O3 / c9-8-11-6-5（7（15）12-8）10-4-13（6）16-3-1-2-14 / h4,14H，1-3H2，（H3,9,11,12,15）
InchiKey	UWCACOXRVYDNEE-UHFFFAOYSA-N
分子式 Formula	C8H11N5O3
分子量 Molecular Weight	225.2
闪点 FP	282.5±32.9°摄氏度data available
熔点 Melting point	No data available
沸点 Boiling point	760毫米汞柱时543.6±60.0°C
Polarizability极化度
密度 Density	1.8±0.1克/厘米3
蒸汽压 Vapor Pressure	25°C时为0.0±1.5 mmHg
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	存放在阴凉干燥处

BRL44385(114778-60-8)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:BRL44385,BRL44385,BRL44385,BRL44385,BRL44385,BRL44385,BRL44385,BRL44385,BRL44385,BRL44385,

产品说明	BRL44385(114778-60-8)是一种新型鸟嘌呤类似物，是1型和2型单纯疱疹病毒和水痘带状疱疹病毒的有效和选择性抑制剂。
Introduction	BRL44385(114778-60-8)is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSVandHSV2), varicella zoster virus (VZV) and Epsteinarr virus (EBV).
Application1
Application2
Application3

BRL44385(114778-60-8)药理学：

BRL44385是一种新型鸟嘌呤类似物，是1型和2型单纯疱疹病毒和水痘带状疱疹病毒的有效和选择性抑制剂。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

M. R. Harnden, et al. Synthesis, oral bioavailability and in vivo activity of acetal derivatives of the selective antiherpesvirus agent 9-(3-hydroxypropoxy) guanine (SRL 44385). Antiviral Chemistry &

Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent PMID 8013273; Drug metabolism and disposition: the biological

Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells Antimicrobial agents and chemotherapy8723485 1996-05-01

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxymethyl)propoxy]purines Journal of medicinal chemistry2153202 1990-01-01

BRL44385(114778-60-8)参考文献：

1.Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent.
Harrell AW;Wheeler SM;East P;Clarke SE;Chenery RJ Drug Metab Dispos. 1994 Mar-Apr;22(2):189-93.

BRL 55792, BRL 55791, and BRL 55039 are prodrugs of an active antiviral agent 9-(3-hydroxypropoxy) guanine (BRL 44385). The prodrugs were 6-deoxygenated analogs of BRL 44385, with ether groups substituted at the 9-position: BRL 55792 with an (isopropoxymethyloxy)propoxy group, BRL 55791 with a (methoxymethyloxy)propoxy group, and BRL 55039 with an ethoxypropoxy group. Conversion of the prodrugs to BRL 44385 had been demonstrated in vivo in the rat and involved 6-oxidation followed by dealkylation. Metabolism was studied in rat liver in vitro systems to find a model to evaluate BRL 44385 production. Rat hepatocytes performed both reaction steps and were used to assess which of the three prodrugs demonstrated greatest production of the active drug. BRL 55792 demonstrated greatest conversion in vitro, and this was in agreement with in vivo data. The production of BRL 44385 from BRL 55792 was also demonstrated in human hepatocyte incubations, providing evidence that these reactions can occur in humans, thereby increasing confidence that BRL 55792 would be suitable prodrug for human therapy. Further experiments were performed to investigate the enzymes involved in these conversions. The 6-oxidation step occurred in the cytosol.

2.Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxy-guanine analogues as prodrugs of an antiviral agent.
Harrell AW;Wheeler SM;East P;Clarke SE;Chenery RJ Drug Metab Dispos. 1994 Jan-Feb;22(1):124-8.

BRL 55792, BRL 55791, and BRL 55039 are prodrugs of an active anti-viral agent 9-(3-hydroxypropoxy) guanine, (BRL 44385). The prodrugs were 6-deoxygenated analogues of BRL 44385 with ether groups substituted at the 9-position: BRL 55792 with an (isopropoxymethyloxy)propoxy group, BRL 55791 with a (methoxymethyloxy)propoxy group, and BRL 55039 with an ethoxypropoxy group. Conversion of the prodrugs to BRL 44385 had been demonstrated in vivo in rat and involved 6-oxidation followed by dealkylation. Metabolism was studied in rat liver in vitro systems to find a model to evaluate BRL 44385 production. Rat hepatocytes performed both reaction steps and were used to assess which of the three prodrugs demonstrated greatest production of the active drug. BRL 55792 demonstrated greatest conversion in vitro and this was in agreement with in vivo data. The production of BRL 44385 from BRL 55792 was also demonstrated in human hepatocyte incubations providing evidence that these reactions can occur in man thereby increasing confidence that BRL 55792 would be a suitable prodrug for human therapy. Further experiments were performed to investigate the enzymes involved in these conversions. The 6-oxidation step occurred in the cytosol.

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