864953-39-9|福斯他沙韦|Fostemsavir Tris|MFCD23098797-范德生物科技公司

福斯他沙韦

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names：
Fostemsavir Tris
CAS号：
864953-39-9
MDL Number： MFCD23098797
MF(分子式)： C29H37N8O11P MW(分子量)： 704.62
EINECS: Reaxys Number:
Pubchem ID:46892186 Brand:BIOFOUNT

福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)是HIV-1附着抑制剂,可用于治疗HIV-1感染。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000692-5mg	5mg		¥ 2156.00	¥ 2156.00		Backorder	- +	¥ 0.00
YZM000692-2mg	2mg	>97%	¥ 1170.00	¥ 1170.00		2-3天	- +	¥ 0.00

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中文别名	福斯他沙韦(864953-39-9);福斯沙韦氨丁三醇;
英文别名	Fostemsavir Tris(864953-39-9);Fostemsavir tromethamine; BMS-663068 Tris; BMS 663068 Tris; BMS663068 Tris Publication citing BOC Sciences Products;
CAS号	864953-39-9
SMILES	O=C(N1CCN(C(C2=CC=CC=C2)=O)CC1)C(C3=CN(COP(O)(O)=O)C4=C3C(OC)=CN=C4N5N=C(C)N=C5)=O.OCC(CO)(N)CO
Inchi	InChI=1S/C25H26N7O8P.C4H11NO3/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17;5-4(1-6,2-7)3-8/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38);6-8H,1-3,5H2
InchiKey	RRGJSMBMTOKHTE-UHFFFAOYSA-N
分子式 Formula	C29H37N8O11P
分子量 Molecular Weight	704.62
闪点 FP
熔点 Melting point	No data available
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	请根据产品建议的存储条件进行存储,Please store the product under the recommended condition sin the description.

福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)是一种新型附着抑制剂,靶向HIV-1gp120,可防止其与CD4 + T细胞结合.
Introduction	福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)is the phosphonooxymethyl prodrug of BMS26529.
Application1	Fostemsavir Tris (BMS63068 (Tris)) is a novel attachment inhibitor that targetsHIVgp120 and prevents its binding to CD4+T cells.
Application2
Application3

福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)药理学：

BMS-663068 tris是开发中的HIV-1附着抑制剂，可用于治疗HIV-1感染。IC50值：目标：HIVBMS-663068是BMS-626529的前药，它与病毒包膜糖蛋白gp120结合并干扰病毒与细胞CD4受体的附着。在有或没有利托那韦的情况下，连续8天使用BMS-663068会导致血浆HIV-1 RNA水平大幅下降，并且通常具有良好的耐受性。BMS-663068作为抗逆转录病毒疗法联合治疗的一部分，需要进行长期的临床试验。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)危害标识：

象形图

信号	Warning
GHS危险说明	Aggregated GHS information provided by 5 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
	H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
	H361 (60%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
	H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P201, P202, P260, P261, P272, P280, P281, P302+P352, P308+P313, P314, P321, P333+P313, P363, P405, and P501
	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507

福斯他沙韦(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)参考文献：

1、In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068
Beata Nowicka-Sans 1, Yi-Fei Gong, Brian McAuliffe, Ira Dicker, Hsu-Tso Ho, Nannan Zhou, Betsy Eggers, Pin-Fang Lin, Neelanjana Ray, Megan Wind-Rotolo, Li Zhu, Antara Majumdar, David Stock, Max Lataillade, George J Hanna, John D Matiskella, Yasutsugu Ueda, Tao Wang, John F Kadow, Nicholas A Meanwell, Mark Krystal

Abstract BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. In order to better understand the anti-HIV-1 spectrum of BMS-626529 against HIV-1, in vitro activities against a wide variety of laboratory strains and clinical isolates were determined. BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates; however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses. The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions. Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life. Finally, in two-drug combination studies, BMS-626529 demonstrated additive or synergistic interactions with antiretroviral drugs of different mechanistic classes. These results suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound.

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