476-69-7|紫菫定酚|Corydine|MFCD00076020-范德生物科技公司

紫菫定酚

NMR下载 COA and HPLC MSDS下载
names：
Corydine
CAS号：
476-69-7
MDL Number： MFCD00076020
MF(分子式)： C20H23NO4 MW(分子量)： 341.4
EINECS:No data available Reaxys Number:No data available
Pubchem ID:10153 Brand:BIOFOUNT

紫菫定酚(476-69-7,Corydine)是一种天然存在的生物碱，可从巴豆echinocarpus 叶子中提取.Corydine有效抑制逆转录酶（逆转录酶，RT）活性，IC₅₀为356.8μg/mL。Corydinez在体外具有抗HIV潜力，浓度为450μg/ mL时抑制40％的HIV-1逆转录酶活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000679-5mg	5mg		¥ 4080.00	¥ 4080.00		Backorder	- +	¥ 0.00
YZM000679-1mg	1mg	>97%	¥ 1306.50	¥ 1306.50		2-3天	- +	¥ 0.00

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中文别名	紫菫定酚(476-69-7);紫定酚;(+)-延胡索碱;
英文别名	Corydine(476-69-7);Glaucentrin; Glaucentrine; d-Corydine; corydine hydrochloride;corydine, (R)-isomer;
CAS号	476-69-7
SMILES	OC1=C(OC)C=C2C3=C1C(C(OC)=C(OC)C=C4)=C4C[C@]3([H])N(CC2)C
Inchi	InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InchiKey	IDQUPXZJURZAGF-ZDUSSCGKSA-N
分子式 Formula	C20H23NO4
分子量 Molecular Weight	341.4
闪点 FP	259.7±30.1 °C
熔点 Melting point	165-167℃
沸点 Boiling point	505.7±50.0 °C at 760 mmHg
Polarizability极化度	38.1±0.5 10-24cm3
密度 Density	1.2±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.4 mmHg at 25°C
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	请根据产品建议的存储条件进行存储,Please store the product under the recommended condition sin the description.

紫菫定酚(476-69-7,Corydine)毒理性质：

生物	测试类型	路线	剂量	影响	参考
mouse	LD50	subcutaneous	115 mg/kg (115 mg/kg)		Farmakologiya i Toksikologiya, 31(44), 1968 [PMID:5691957]

紫菫定酚(476-69-7,Corydine)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：紫菫定酚试剂,紫菫定酚杂质,紫菫定酚中间体,紫菫定酚密度,紫菫定酚合成,紫菫定酚溶解度,紫菫定酚旋光度,紫菫定酚闪点,紫菫定酚熔点,紫菫定酚购买,

产品说明	紫菫定酚(476-69-7,Corydine)是一种有效的天然存在的生物碱，可从Croton echinocarpus叶子中提取
Introduction	紫菫定酚(476-69-7,Corydine) is a naturally occurring alkaloid which can be extracted from plants such asCroton echinocarpusleaves.
Application1	紫菫定酚具有抑菌，清热解毒，杀虫止痒的作用。Corydine是一种具有抗菌和抗肿瘤活性的生物碱。
Application2	Corydine is efficient on inhibitingreverse transcriptase activity with an IC50of356.8μg/mL.
Application3	Corydine displays significant in vitro antiIVpotential, inhibiting 40% of ?the HIV reverse transcriptase enzyme activity at a concentration of ?450 μg/mL of ?Corydine.

紫菫定酚(476-69-7,Corydine)药理学：

※Corydine是一种天然存在的生物碱，可从巴豆echinocarpus 叶子中提取.Corydine有效抑制逆转录酶（逆转录酶，RT）活性，IC₅₀为356.8μg/mL。Corydinez在体外具有抗HIV潜力，浓度为450μg/ mL时抑制40％的HIV-1逆转录酶活性。

※紫菫定酚具有抑菌，清热解毒，杀虫止痒的作用。

※Corydine是一种具有抗菌和抗肿瘤活性的生物碱。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

N.Ravanelli, et al. Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential. South African Journal of Botany. 2016 Jan, 102: 153-156

Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine PMID 2290126; Journal of pharmacobio-dynamics 1990 Jul; 13(7):426-31 Name

Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort PMID 17574358; Journal of ethnopharmacology 2007 Aug; 113(1):179-82 Name matches: acetylcholine

Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes PMID 124343; Journal of pharmaceutical sciences 1975 Jan; 64(1):53-62 Name

Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists PMID 32796875; Scientific reports 2020 Aug; 10(1):13804 Name matches: arre

紫菫定酚(476-69-7,Corydine)参考文献：

1.[Alkaloids from Dactylicapnos scandens Hutch].
Wang F1, Hu X, Chen H, Ma J, Wang J, Hou A. Zhongguo Zhong Yao Za Zhi. 2009 Aug;34(16):2057-9.

OBJECTIVE: To investigate the alkaloids in the roots of Dactylicapnos scanden (D. Don) Hutch.

2.Comprehensive separation and analysis of alkaloids from Stephania yunnanensis by counter-current chromatography coupled with liquid chromatography tandem mass spectrometry analysis.
Dai X1, Hu R, Sun C, Pan Y. J Chromatogr A. 2012 Feb 24;1226:18-23. doi: 10.1016/j.chroma.2011.10.022. Epub 2011 Oct 14.

The polar compounds such as alkaloid compounds are important bioactive components in traditional Chinese medicines. In present study, a comprehensive method for separation and analysis of polar compounds from the polar fraction of traditional Chinese medicine Stephania yunnanensis was established. Both the major components and minor components were analyzed by counter-current chromatography combined with liquid chromatography tandem mass spectrometry (LC-MS(n)). From 50 mg polar fraction of crude extract, 15.2mg corydine and 4.8 mg stepharine with purities over 90% were successfully separated via a polar solvent system n-butanol: methanol: water (4:1:5, v/v) with 10 mM NaOH as an additive in the lower phase, in one step operation. Their structures were further identified by 1H NMR and FTICR-MS. Besides, three minor components were identified by HPLC-MS(n) based on the fragmentation behavior of the purified compounds.

3.Aporphine alkaloids from the roots of Stephania viridiflavens.
Zhang M1, Liang G, Yu J, Pan W. Nat Prod Res. 2010 Aug;24(13):1243-7. doi: 10.1080/14786410903125393.

Further investigation on the phytochemistry of the medicinal plant Stephania viridiflavens led to the isolation of a new naturally occurring aporphine alkaloid, (+)-6R, 6aS-isocorydine N(beta)-oxide (1), together with three known aporphine alkaloids: (+)-6R, 6aS-corydine N(beta)-oxide (2), (+)-N-methyl-laurotetanine (3) and (+)-stepharine (4). The structure and stereochemistry of 1 were determined on the basis of spectroscopic methods and confirmed by synthesis. Alkaloids 2-4 were isolated for the first time from this species.

4.Preparative separation of isoquinoline alkaloids from Stephania yunnanensis by pH-zone-refining counter-current chromatography.
Hu R1, Dai X, Lu Y, Pan Y. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1881-4. doi: 10.1016/j.jchromb.2010.05.005. Epub 2010 May 9.

In this paper, five isoquinoline alkaloids were successfully separated from a crude extract of Stephania yunnanensis using pH-zone-refining counter-current chromatography in single-step. With a two-phase solvent system composed of methyl-tert-butyl ether (MtBE)-acetonitrile-water (2:2:3, v/v) where triethylamine (10 mM) was added to the upper organic phase as a retainer and hydrochloric acid (5 mM) to the aqueous mobile phase as an eluter. From 1.4 g crude extract, 68.7 mg isocorydine, 78.2 mg corydine, 583.4 mg tetrahydropalmatine, 36.3 mg N-methylasimilobine, and 47.3 mg anonaine were separated with purities over 90%. Their structures were identified by (1)H NMR, (13)C NMR, ESI-MS data.

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