28302-36-5|叶绿素铜钠|Sodium copper chlorophyllin B|No data available-范德生物科技公司

叶绿素铜钠

NMR下载 COA and HPLC MSDS下载
names：
Sodium copper chlorophyllin B
CAS号：
28302-36-5
MDL Number： No data available
MF(分子式)： C34H29CuN4Na3O7 MW(分子量)： 738.13
EINECS:247-608-4 Reaxys Number:No data available
Pubchem ID:135116291 Brand:BIOFOUNT

叶绿素铜钠(28302-36-5,Sodium copper chlorophyllin B)对流感病毒和HIV发挥抗病毒活性，叶绿素铜钠的IC₅₀s值都是50到100μM。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000656-1g	1g	>95%	¥ 506.00	¥ 506.00		2-3天	- +	¥ 0.00
YZM000656-500mg	500mg	>97%	¥ 390.00	¥ 390.00		2-3天	- +	¥ 0.00

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中文别名	叶绿素铜钠(28302-36-5);铜酸盐（3-），[（7S，8S）-3-羧基-5-（羧甲基）-13-乙烯基-18-乙基-17-甲酰基- 7、8-二氢，2、8、12-三甲基-21H，23H-吗啡-7-丙（5-）-κN21，κN22，κN23 ，κN24]-，钠（1：3）;
英文别名	Sodium copper chlorophyllin B(28302-36-50);SodiuM Copper Chlorophyllin;SodiuM Copper Chlorophyllin;copper,trisodium,3-[(2S,3S)-20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-23-id-2-yl]propanoate;
CAS号	28302-36-5
SMILES	[Na +]。[Na +]。[Na +]。[Cu + 2] .CCc1c（C = O）c2cc3 [n-] c（cc4nc（[C @@ H]（CCC（= O）[O-]））[C @@ H] 4C）c（C
Inchi	InChI = 1S / C34H34N4O7.Cu.3Na / c1-6-18-15（3）23-11-24-16（4）20（8-9-29（40）41）32（37-24）21（ 10-30（42）43）33-31（34（44）45）17（5）25（38-33）12-27-19（7-2）22（14-39）28（36-27） 13-26（18）35-23 ;;;; / h6,11-14,16,20H，1,7-10H2,2-5H3，（H5,35,36,37,38,39,40,41 ，42,43,44,45）;;; / q; +2; 3 * + 1 / p-5 / t16-，20-;;;; / m0 .... / s1
InchiKey	KYLOFEQLMQEHBO-JOKPRTCASA-I
分子式 Formula	C34H29CuN4Na3O7
分子量 Molecular Weight	738.13
闪点 FP	431.6oC
熔点 Melting point	No data available
沸点 Boiling point	790oC at 760mmHg
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility	生物体外In Vitro:H2O : 10 mg/mL(13.55 mM;Need ultrasonic)DMSO溶解度6.67 mg/mL(9.04 mM;Need ultrasonic)
性状	绿色至黑色粉末,Power
储藏条件 Storage conditions	2-8oC,-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

叶绿素铜钠(28302-36-5,Sodium copper chlorophyllin B)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：叶绿素铜钠试剂,叶绿素铜钠杂质,叶绿素铜钠中间体,叶绿素铜钠密度,叶绿素铜钠溶解度,叶绿素铜钠旋光度,叶绿素铜钠合成,叶绿素铜钠闪点,叶绿素铜钠购买,叶绿素铜钠MSDS,

产品说明	叶绿素铜钠(28302-36-5,Sodium copper chlorophyllin B)对流感病毒和HIV发挥抗病毒活性,其IC50s 值都是 50 到 100 μM
Introduction	叶绿素铜钠(28302-36-5,Sodium copper chlorophyllin B)exertsantiviralactivities againstInfluenza virusandHIVwithIC50s of50 to 100μM for both of them.
Application1	叶绿素B铜钠对流感病毒和HIV发挥抗病毒活性，其IC50s值都是50到100μM。
Application2
Application3

叶绿素铜钠(28302-36-5,Sodium copper chlorophyllin B)药理学:

※叶绿酸铜纳主要含铜叶绿素铜钠（三钠）和叶绿素铜钠（二钠）。性质：粉末状墨绿色，易溶于水。来源：菠菜为原料，用现代的生物技术提取而成的天然色素。用途作为医药原料，可促进胃肠溃疡面的愈合，还可用于急慢性肝炎及肝炎引起的肝肿大、肝硬化、促进肝功能恢复；作为食品着色剂。

※叶绿酸铜纳在200 µM时表现出流感病毒吸附（P <0.05）。集成电路₅₀ 和50％的细胞毒性浓度（CC₅₀）叶绿素铜钠盐的浓度分别为50至100 µM和200至400 µM。叶绿素B铜钠盐还以2.5 mM抑制HIV吸附（P <0.05）。集成电路₅₀ 和CC₅₀ 的叶绿素铜钠盐浓度分别为50至100 µM和200至400 µM.

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Akiko Ito, et al. In Vitro Inhibition of Cytopathic Effect of Influenza Virus and Human Immunodeficiency Virus by Bamboo Leaf Extract Solution and Sodium Copper Chlorophyllin. Yonago Acta Med. 2016 Ma

叶绿素铜钠(28302-36-5,Sodium copper chlorophyllin B)参考文献：

1.Fighting fish parasites with photodynamically active chlorophyllin.
Häder DP1, Schmidl J2, Hilbig R3, Oberle M4, Wedekind H4, Richter P5. Parasitol Res. 2016 Mar 3. [Epub ahead of print]

Water-soluble chlorophyll (chlorophyllin) was used in a phototoxic reaction against a number of fish ectoparasites such as Ichtyobodo, Dactylogyrus, Trichodina, and Argulus. Chlorophyllin is applied to the water at concentrations of several micrograms per milliliter for a predefined incubation time, and afterwards, the parasites are exposed to simulated solar radiation. Application in the dark caused only little damage to the parasites; likewise, light exposure without the addition of the photosensitizer was ineffective. In Ichthyobodo, 2 μg/mL proved sufficient with subsequent simulated solar radiation to almost quantitatively kill the parasites, while in Dactylogyrus, a concentration of about 6 μg/mL was necessary. The LD50 value for this parasite was 1.02 μg/mL. Trichodina could be almost completely eliminated at 2 μg/mL. Only in the parasitic crustacean Argulus, no killing could be achieved by a photodynamic reaction using chlorophyllin.

2.??Topical Treatment With Liposomal Sodium Copper Chlorophyllin Complex in Subjects With Facial Redness and Erythematotelangiectatic Rosacea: Case Studies.
Vasily DB. J Drugs Dermatol. 2015 Oct;14(10):1157-9.

Physicians are often presented with patients complaining of facial redness and difficult to control rosacea. The water soluble sodium copper chlorophyllin complex has been shown to have anti-oxidant, anti-inflammatory, and anti-bacterial activities in vitro and anti-redness, pore reduction, and anti-acne activities in pilot clinical studies. In these case studies, the safety and efficacy of a topical gel containing a liposomal suspension of sodium copper chlorophyllin complex was assessed in subjects with facial redness and erythematotelangiectatic rosacea.

3.Roles of chlorophyllin in cell proliferation and the expression of apoptotic and cell cycle genes in HB4a non-tumor breast cells.
D Epiro GF1, Semprebon SC1, Niwa AM1, Marcarini JC2, Mantovani MS1. Toxicol Mech Methods. 2016 Apr 21:1-7. [Epub ahead of print]

Chlorophyllin (Chl) has attracted interest in the scientific community due to its chemopreventive and antimutagenic properties. However, the molecular mechanisms of action of Chl remain unclear. This study assesses the effects on cell proliferation and the expression of genes involved in apoptosis, and the cell cycle in HB4a cells treated with Chl. Chl was cytotoxic and induced apoptosis to HB4a cells at 400 μg/mL. Analysis of gene expression showed that there was a decrease in the mRNA level of BIRC5 and CCNA2 genes involved in apoptosis and cell cycle progression, respectively. The proapoptotic gene BAX and the antiapoptotic genes BCL-2 and BCL-XL were upregulated. The cytotoxicity of Chl has been attributed to increases in the expression of BAX and decreases in the expression of genes involved in the cell cycle, but increases in the expression of anti-apoptotic genes suggests a mechanism for protection from cell death induced by Chl. This study provides important information about mechanisms that protect against or trigger damaging processes in non-tumor cells.

4.Treatment of ichthyophthiriasis with photodynamically active chlorophyllin.
Häder DP1, Schmidl J2, Hilbig R3, Oberle M4, Wedekind H4, Richter PR5. Parasitol Res. 2016 Apr;115(4):1509-17. doi: 10.1007/s00436-015-4884-2. Epub 2015 Dec 23.

Water-soluble chlorophyll (chlorophyllin) exerts pronounced photodynamic activity on fish parasites. In order to determine its potential as a remedy against ectoparasites in fish carps were incubated in water with defined concentrations of chlorophyllin. The main focus of the experiments was on the ciliate Ichthyophthirius multifiliis (Fouquet) which is responsible for considerable losses in livestock in aquaculture. As malachite green, which in the past efficiently cured infected fishes, is banned because of its possible carcinogenicity; no effective remedy is presently available in aquaculture to treat ichthyophthiriasis. Using chlorophyllin, the number of trophonts was significantly reduced (more than 50 %) after 3 h incubation of infested fish at 2 and 4 mg/L and subsequent irradiation with simulated solar radiation. The lack of reinfection after light treatment indicates that also the remaining parasites have lost their multiplication capacity.

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