1443460-91-0|GSK2838232|GSK2838232|No data available-范德生物科技公司

GSK2838232

NMR下载 COA and HPLC MSDS下载
names：
GSK2838232
CAS号：
1443460-91-0
MDL Number： No data available
MF(分子式)： C48H73ClN2O6 MW(分子量)： 809.56
EINECS:No data available Reaxys Number:No data available
Pubchem ID:71580991 Brand:BIOFOUNT

GSK2838232(1443460-91-0)是抗艾滋病毒剂，用于治疗艾滋病和/或制止艾滋病毒感染传播的药物。这些不包括用于治疗与艾滋病相关的症状或机会性感染的药物.通过高含量成像确定抗病毒活性是在10 uM时抑制SARS-CoV-2诱导的Caco-2细胞的细胞毒性，作用时间为10 uM。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000654-10mg	10mg	99.26%	¥ 5062.00	¥ 5062.00		2-3天	- +	¥ 0.00
YZM000654-5mg	5mg	99.26%	¥ 3412.50	¥ 3412.50		2-3天	- +	¥ 0.00

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中文别名	GSK2838232(1443460-91-0),GSK-2838232;GSK2838232;GSK 2838232;4-[[（（3aR，5aR，5bR，7aR，9S，11aR，11bR，13aS）-3a-[（1R）-2-[（4-氯苯基）甲基-[2-（二甲基氨基）乙基]氨基]- 1-羟乙基] -5a，5b，8,8,11a-五甲基-2-氧代-1-丙-2-基-4,5,6,7,7a，9,10,11,11b，12,13 ，13a-十二烷基-3H-环戊[a] chrysen-9-基]氧基] -2,2-dime;
英文别名	GSK2838232(1443460-91-0),4-[[(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-[(1R)-2-[(4-chlorophenyl)methyl-[2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-5a,5b,8,8,11a-pentamethyl-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3H-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dime;
CAS号	1443460-91-0
SMILES	CC（C）C1 = C2C3CCC4C5（CCC（C（C5CCC4（C3（CCC2（CC1 = O）C（CN（CCN（C）C）CC6 = CC = C（C = C6）Cl）O）C）C）C）C）（C）
Inchi	InChI = 1S / C48H73ClN2O6 / c1-30（2）40-34（52）26-48（37（53）29-51（25-24-50（10）11）28-31-12-14-32（ 49）15-13-31）23-22-46（8）33（41（40）48）16-17-36-45（7）20-19-38（57-39（54）27-43（ 3,4）42（55）56）44（5,6）35（45）18-21-47（36,46）9 / h12-15,30,33,35-38,53H，16-29H2， 1-11H3，（H，55,56）/ t33-，35 +，36-，37 +，38 +，45 +，46-，47-，48 + / m1 / s1
InchiKey	MEOWKUXNVNJAMY-PZFKGGKESA-N
分子式 Formula	C48H73ClN2O6
分子量 Molecular Weight	809.56
闪点 FP	448.0±34.3°摄氏度
熔点 Melting point	No data available
沸点 Boiling point	817.1±65.0°C \| 条件：压：760 Torr
Polarizability极化度	No data available
密度 Density	1.2±0.1克/厘米3
蒸汽压 Vapor Pressure	25°C时0.0±3.1 mmHg
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 50 mg/mL(61.76 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	白色至灰白色固体粉末,Power
储藏条件 Storage conditions	存放在阴凉干燥处，短期（数天至数周）在0-4℃，长期（数月至数年）在-56℃。保质期2年。

GSK2838232(1443460-91-0)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:GSK2838232试剂,GSK2838232杂质,GSK2838232中间体,GSK2838232密度,GSK2838232合成,GSK2838232密度,GSK2838232溶解度,GSK2838232旋光度,GSK2838232闪点,GSK2838232购买,

产品说明	(1443460-91-0)GSK2838232 GSK2838232是Betulin的衍生物,是一种新型的人类免疫病毒(HIV)成熟抑制剂,正在开发用于治疗慢性HIV感染.
Introduction	GSK2838232(1443460-91-0)inhibit HIV reverse transcriptase activity across a broad panel of HIV isolates, extracted from patent WO/2013090664A1, compound51.
Application1
Application2
Application3

GSK2838232(1443460-91-0)药理学：
GSK2838232(1443460-91-0)是Betulin的衍生物，GSK2838232是一种新型的人类免疫病毒（HIV）成熟抑制剂，正在开发用于治疗慢性HIV感染。GSK2838232是抗艾滋病毒剂，用于治疗艾滋病和/或制止艾滋病毒感染传播的药物。这些不包括用于治疗与艾滋病相关的症状或机会性感染的药物.通过高含量成像确定抗病毒活性是在10 uM时抑制SARS-CoV-2诱导的Caco-2细胞的细胞毒性，作用时间为10 uM。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Hatcher Mark Andrew, et al. Preparation of betulin derivatives for the treatment of HIV. From PCT Int. Appl. (2013), WO 2013090664 A1 20130620.

GSK2838232(1443460-91-0)参考文献：

1、US2018042944 药物成分 2017-10-19
This web page summarizes information in PubChem about patent US-2018042944-A1. This includes chemicals mentioned, as reported , as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page. The present Invention relates to long acting pharmaceutical compositions of betulin derivatives or pharmaceutically acceptable salts thereof, useful in the treatment or prevention of Human Immunodeficiency Virus (HIV) infections.

2、US2017348324 桦木的衍生物 2017-08-24
This web page summarizes information in PubChem about patent US-2017348324-A1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed,
The present invention relates to compounds characterized by having a structure according to the following Formula I: n n n n n n n n n n , or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

3、US2017252356 用木犀草素衍生物治疗HIV的化合物和组合物 2017-03-21
This web page summarizes information in PubChem about patent US-2017252356-A1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed。
The present invention relates to compounds characterized by having a structure according to the following Formula I: n n n n n n n n n n or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

4、US2016120878 桦木的衍生物 2015-12-23 2016-05-05
This web page summarizes information in PubChem about patent US-2016120878-A1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed,
The present invention relates to compounds characterized by having a structure according to the following formula I: n n n n n n n n n n n n or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

5、US2014357643 桦木素衍生物 2014-08-18 2014-12-04
This web page summarizes information in PubChem about patent US-2014357643-A1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed,
The present invention relates to compounds characterized by having a structure according to the following Formula I: n n n n n n n n n n , or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

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