37300-21-3|聚戊糖多硫醇|Pentosan Polysulfate|No data available-范德生物科技公司

聚戊糖多硫醇

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names：
Pentosan Polysulfate
CAS号：
37300-21-3
MDL Number： No data available
MF(分子式)： C 10 H 18 O 21 S 4 MW(分子量)： 4000-6000
EINECS:No data available Reaxys Number:No data available
Pubchem ID:37720 Brand:BIOFOUNT

聚戊糖多硫醇(37300-21-3,Pentosan Polysulfate)是一种半合成的多硫酸木聚糖，是一种具有类肝素特性的硫酸戊糖基多糖。戊聚糖多硫酸盐是一种口服生物可利用的半合成药物，具有抗炎和促成软骨生成的特性。戊聚糖是一种有效且选择性的抗艾滋病毒药物。聚戊糖多硫醇是细胞膜通透性抑制剂。

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中文别名	聚戊糖多硫醇(37300-21-3),戊聚糖多硫酸钠,戊聚糖多硫酸盐,[(2R,3R,4S,5R)-2-羟基-5-[(2S,3R,4S,5R)-5-羟基-3,4-二磺基氧基四氢吡喃-2-基]氧基-3-磺基氧基四氢吡喃-4-基]氢硫酸盐;
英文别名	Pentosan Polysulfate(37300-21-3);4-O-(2,3-Di-O-sulfo-β-D-xylopyranosyl)-2,3-di-O-sulfo-β-D-xylopyr anose;
CAS号	37300-21-3
SMILES	[Pentosan Polysulfate]
Inchi	InChI=1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
InchiKey	FCCNSUIJIOOXEZ-SJYYZXOBSA-N
分子式 Formula	C 10 H 18 O 21 S 4
分子量 Molecular Weight	4000-6000
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	39.9±0.5 10-24cm3
密度 Density	2.3±0.1 g/cm3
蒸汽压 Vapor Pressure	No data available
溶解度Solubility	生物体外In Vitro:DMSO溶解度< 1 mg/mL(insoluble or slightly soluble)H2O< 0.1 mg/mL(insoluble)
性状	固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

聚戊糖多硫醇(37300-21-3,Pentosan Polysulfate)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：聚戊糖多硫醇试剂,聚戊糖多硫醇杂质,聚戊糖多硫醇中间体,聚戊糖多硫醇密度,聚戊糖多硫醇合成,聚戊糖多硫醇溶解度,聚戊糖多硫醇旋光度,聚戊糖多硫醇闪点,聚戊糖多硫醇结构式,聚戊糖多硫醇购买,

产品说明	聚戊糖多硫醇(37300-21-3,Pentosan Polysulfate)是一种有效的口服生物可利用的半合成药物，具有抗炎和促软骨生成的特性
Introduction	聚戊糖多硫醇(37300-21-3,Pentosan Polysulfate)is an orally bioavailable medication with antinflammatory and prohondrogenic properties. Pentosan Polysulfate also is a potent and selective antiIVagent.
Application1	Pentosan Polysulfate is used for the treatment of ?interstitial cystitis.
Application2	聚戊糖多硫醇是细胞膜通透性抑制剂。
Application3

聚戊糖多硫醇(37300-21-3,Pentosan Polysulfate)药理学：
聚戊糖多硫醇是一种低分子量的肝素样化合物。它具有抗凝血和纤溶作用。聚戊糖多硫醇是半合成的肝素样葡糖胺聚糖。尽管其作用机理尚不清楚，但戊聚戊糖多硫醇可通过防止刺激性溶质到达被其包裹的细胞来控制细胞的通透性。经口服施用，排泄的聚戊糖多硫醇粘附在膀胱壁上，防止刺激物进入膀胱细胞以及间质性膀胱炎（IC）的发展或进展，这是一些化学疗法的并发症。该试剂还具有抗凝血和纤溶特性。聚戊糖多硫醇是抗凝剂，防止血液凝结的代理。聚戊糖多硫醇是木糖硫酸氢盐的聚合物，每个碳水化合物单体包含两个硫酸盐基团。它结合成纤维细胞生长因子（FGFs）以及其他肝素结合生长因子。已经显示它也与FGFR-1 的肝素结合位点相互作用。聚戊糖多硫醇抑制转染了FGF-4的SW13肾上腺皮质细胞的生长以及转染了FGF-1或FGF-4的MCF-7乳腺癌细胞的致瘤性。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Schuchman EH, et al. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013;8(1):e54459.

Baba M, et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 1988 Sep;9(6):335-43.

Wu J, et al. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest. 2011 Oct;91(10):1459-71.

聚戊糖多硫醇(37300-21-3,Pentosan Polysulfate)参考文献：

1，戊聚糖钠和硫酸钙多硫酸盐的抗凝和抗血栓形成作用的实验研究。
Giedroj? J;Radziwon P;Klimiuk M;Bielawiec M;Breddin HK;K?oczko J J Physiol Pharmacol. 1999 Mar;50(1):111-9.
In the present study we have compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulphate (Na-PPS, Ca-PPS). The antithrombotic effect of these agents have been investigated in an experimental thrombosis model in which rat mesenteric venules diameter of 20-30 microm were injured by well defined Argon laser lesions. Furthermore, the in vivo and in vitro anticoagulant activities (aPTT, Heptest) of these agents have been studied. Thrombus formation was significantly inhibited after s.c. injection of Na-PPS and Ca-PPS in doses above 10 mg/kg. The duration of the antithrombotic effect lasted 8 h for Na-PPS and 12 h for Ca-PPS. After oral administration of Na-PPS an antithrombotic effect was not observed. Oral application of Ca-PPS in doses higher than 20 mg/kg significantly inhibited thrombus formation. Na-PPS and Ca-PPS markedly prolonged clotting time in aPTT and Heptest in concentrations ranging from 0.01 to 0.2 mg/ml rat PTT. Two h after s.c. administration of these agents in a dose 10 mg/kg, the aPTT increased 3-fold and Heptest 2.5-fold compared to controls. After oral application of 50 mg/kg Na-PPS and Ca-PPS no effect on coagulation test could be measured.

2.硫酸化多糖的细胞表面受体：巨噬细胞亚群的潜在标志物。
Chong AS;Parish CR Immunology. 1986 Jun;58(2):277-84.
The expression of a diverse array of receptors for sulphated polysaccharides on lymphocytes has been demonstrated by Parish & Snowden (1985). This paper presents evidence to suggest that other cell types, namely macrophages, polymorphonuclear leucocytes, mast cells and fibroblasts, can bind similar polysaccharides. Using a rosetting assay and eleven structurally unique polysaccharides, each cell type was observed to bind a characteristic array of these polysaccharides. Analysis of the polysaccharide reactivity of macrophages revealed that BCG-activated and thioglycollate-elicited macrophages express an expanded repertoire of reactivity compared to resident peritoneal macrophages. For example, only thioglycollate-elicited macrophages, but not resident and BCG-activated peritoneal macrophages, reacted with the glycosaminoglycans, chondroitin-4-sulphate, chondroitin-6-sulphate and dermatan sulphate, while both BCG- and thioglycolate-activated, but not resident peritoneal macrophages, bound pentosan polysulphate-coupled sheep erythrocytes. The expression of the receptors for chondroitin-4 and -6-sulphate was observed to be cyclic and peaked at 2 and 5-6 days after thioglycollate treatment.

3.评论文章：放射直肠疾病的当前治疗选择
Hong JJ;Park W;Ehrenpreis ED Aliment Pharmacol Ther. 2001 Sep;15(9):1253-62.
Radiation proctopathy is a common unfortunate complication following radiation therapy of pelvic malignancies. Symptoms of chronic radiation proctopathy include haematochezia, urgency, constipation, tenesmus, diarrhoea and rectal pain. Currently, a wide variety of pharmacological options, endoscopic cautery techniques and surgical procedures have been proposed for the treatment of chronic radiation proctopathy. Although these have been proposed primarily as treatment for rectal bleeding, the control of other symptoms has been noted with some of these agents. Pharmacological options include 5-aminosalicylic acid preparations, coticosteroid enemas, sucralfate (oral, enemas), formalin, short chain fatty acid enemas, oestrogen/progesterone, hyperbaric oxygen, antioxidants, sodium pentosan polysulphate and misoprostol rectal suppositories. Of these, sucralfate and formalin therapy appear to be effective for bleeding control. Misoprostol rectal suppositories and oral sucralfate may be useful in the prevention of acute and chronic symptoms of radiation proctopathy. Endoscopic cautery techniques have included the use of Nd:YAG laser and argon laser for coagulation of bleeding neovascular telangiectasias.

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