132178-37-1|4-戊炔酸琥珀亚胺酯|Propargyl-C1-NHS ester|MFCD22577791-范德生物科技公司

4-戊炔酸琥珀亚胺酯

NMR下载 COA and HPLC MSDS下载
names：
Propargyl-C1-NHS ester
CAS号：
132178-37-1
MDL Number： MFCD22577791
MF(分子式)： C9H9NO4 MW(分子量)： 195.17
EINECS: Reaxys Number:
Pubchem ID:57339402 Brand:BIOFOUNT

4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)是一种不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗体偶联药物 (ADC) 。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM001020-500mg	500mg	95%	¥ 8560.00	¥ 8560.00		1-3days	- +	¥ 0.00
YZM001020-100mg	100mg	95%	¥ 2800.00	¥ 2800.00		1-3days	- +	¥ 0.00

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中文别名	4-戊炔酸琥珀亚胺酯(132178-37-1);
英文别名	Propargyl-C1-NHS ester(132178-37-1);2,5-dioxopyrrolidin-1-yl pent-4-ynoate;4-Pentynoic acid NHS ester;Propargyl-C1-NHS ester;PROPARGYL-C1-NHS ESTER;4-Pentynoic acid succinimidyl ester;
CAS号	132178-37-1
SMILES	C#CCCC(ON1C(CCC1=O)=O)=O
Inchi	InChI=1S/C9H9NO4/c1-2-3-4-9(13)14-10-7(11)5-6-8(10)12/h1H,3-6H2
InchiKey	VLQOCPXVAZTWQR-UHFFFAOYSA-N
分子式 Formula	C9H9NO4
分子量 Molecular Weight	195.17
闪点 FP	136.3±28.4 °C
熔点 Melting point	No data available
沸点 Boiling point	301.7±44.0 °C at 760 mmHg
Polarizability极化度	18.0±0.5 10-24cm3
密度 Density	1.3±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±0.6 mmHg at 25°C
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	请根据产品建议的存储条件进行存储,Please store the product under the recommended condition sin the description.

4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:32178-37-1试剂,32178-37-1杂质,32178-37-1合成,32178-37-1密度,32178-37-1溶解度,32178-37-1旋光度,32178-37-1闪点,32178-37-1熔点,32178-37-1购买,32178-37-1MSDS,

产品说明	4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)是一种不可降解的 linker,可用于合成抗体偶联药物 (ADC)
Introduction	4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)is a nonclaevable linker for antibodyrugonjugation (ADC).
Application1
Application2
Application3

4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)药理学：

4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)是一种不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗体偶联药物 (ADC) 。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Bastian et al. Selective transformations of complex molecules are enabled by aptameric protective groups. Nature Chemistry, doi: 10.1038/nchem.1402, published online 22 July 2012 http://www.nature.com

Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% 64Cu-CANF-Comb Pharmaceutical Research 2016 27286872

Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study Journal of Nanobiotechnology 2017 28982368

Molecular Targeted Viral Nanoparticles as Tools for Imaging Cancer Virus Hybrids as Nanomaterials 2014 24243252

Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% 64Cu-CANF-Comb Pharmaceutical Research 2016 27286872

4-戊炔酸琥珀亚胺酯(132178-37-1,Propargyl-C1-NHS ester)参考文献：

1、Selective transformations of complex molecules are enabled by aptameric protective groups
Andreas A. Bastian, Alessio Marcozzi & Andreas Herrmann

Abstract Emerging trends in drug discovery are prompting a renewed interest in natural products as a source of chemical diversity and lead structures. However, owing to the structural complexity of many natural compounds, the synthesis of derivatives is not easily realized. Here, we demonstrate a conceptually new approach using oligonucleotides as aptameric protective groups. These block several functionalities by non-covalent interactions in a complex molecule and enable the highly chemo- and regioselective derivatization (>99%) of natural antibiotics in a single synthetic step with excellent conversions of up to 83%. This technique reveals an important structure–activity relationship in neamine-based antibiotics and should help both to accelerate the discovery of new biologically active structures and to avoid potentially costly and cumbersome synthetic routes.

2、Preparation of Peptide and Other Biomolecular Conjugates Through Chemoselective Ligations
Mathieu GalibertOlivier RenaudetDidier BoturynPascal Dumy

Abstract The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne–azide cycloaddition (“click”) reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.

3、Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study
Yi-Zu Liu, May-Show Chen, Chih-Chia Cheng, Shih-Hsun Chen & Jem-Kun Chen

Abstract In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3 to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures. In addition, the optimal operation window for DNA detection ranges from 0 to 0.2 M of NaCl concentration. Therefore, the specimens were prepared in the PBS solution at 150 mM NaCl concentration for target hybridization. The supramolecular complex state of the PNIPAAm-b-ssDNA copolymer brushes transformed into the phase-separated state after the hybridization with 0.5 ng/µL of its target DNA sequence owing to the competition between BMHBs and complementary hydrogen bonds. This phase transformation of the PNIPAAm and probe segments inhibited the proton transfer and significantly increased the resistivity at 25 °C. Moreover, there were no significant changes in the resistivity of the copolymer brushes after hybridization with the target sequence at 45 °C. These results indicated that the phase-separated state of the PNIPAAm-b-ssDNA copolymer brushes, which was generally occurred above the LCST, can be substantially generated after hybridization with its target DNA sequence. By performing the controlled experiments, in the same manner, using another sequence with lengths similar to that of the target sequence without complementarity. In addition, the sequences featuring various degrees of complementarity were exploited to verify the phase separation behavior inside the PNIPAAm-b-ssDNA copolymer thin film.

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