126695-58-7|ATFB, SE|ATFB, SE;非荧光双功能光反应交联探针|MFCD00467437-范德生物科技公司

ATFB, SE

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names：
ATFB, SE;非荧光双功能光反应交联探针
CAS号：
126695-58-7
MDL Number： MFCD00467437
MF(分子式)： C11H4F4N4O4 MW(分子量)： 332.17
EINECS: Reaxys Number:
Pubchem ID:2762579 Brand:BIOFOUNT

ATFB, SE(4-N3Pfp-NHS ester,126695-58-7)是一种非荧光双功能光反应交联探针，也是一种不可降解 (non-cleavable) 的 ADC linker，N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸用于抗体偶联药物 (ADCs) 的合成。

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YZM001009-5mg	5mg	>97%	¥ 0.00	¥ 0.00		Backorder	- +	¥ 0.00
YZM001009-1mg	1mg	>97%	¥ 1200.00	¥ 1200.00		1-3天	- +	¥ 0.00

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中文别名	N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸(126695-58-7);4-叠氮基-2,3,5,6-四氟苯甲酸N-琥珀酰亚胺酯;N-琥珀酰亚胺4-叠氮-2,3,5,6-四氟苯甲酸;4-AZIDChemicalbookO-2,3,5,6-TETRAFLUOROBENZOICACID2,5-DIOXO-PYRROLIDIN-1-YLESTER;4-叠氮基2,3,5,6-四氟苯甲酸，N-琥珀酰亚胺酯;ATFB SE;
英文别名	4-N3Pfp-NHS ester(126695-58-7);Succinimidylester(ATFB,SE);4-Azido-2,3,5,6-tetrafluorobenzoicAcid,N-SuccinimidylEster,ATFBSE;2,5-dioxopyrrolidin-1-yl4-azido-2,3,5,6-tetrafluorobenzoate;4-N3Pfp-NHSester;4-N3PFP-NHSESTERChemicalbook;ATFB,SE[4-Azido-2,3,5,6-tetrafluorobenzoicacid,succiniMidylester];N-Succinimidyl4-Azido-2,3,5,6-tetrafluorobenzoate>;4-azido-2，3，5，6-tetrafluorobenzoicacid2，5-dioxo-pyrrolidin-1-ylester;
CAS号	126695-58-7
SMILES	O=C(ON1C(CCC1=O)=O)C2=C(F)C(F)=C(N=[N+]=[N-])C(F)=C2F
Inchi	InChI=1S/C7HF4N3O2/c8-2-1(7(15)16)3(9)5(11)6(4(2)10)13-14-12/h(H,15,16)
InchiKey	IOJFHZXQSLNAQJ-UHFFFAOYSA-N
分子式 Formula	C11H4F4N4O4
分子量 Molecular Weight	332.17
闪点 FP	No data available
熔点 Melting point	104-105°C
沸点 Boiling point	No data available
Polarizability极化度
密度 Density	No data available
蒸汽压 Vapor Pressure
溶解度Solubility
性状	灰白色至浅黄色固体
储藏条件 Storage conditions	惰性气氛下的-20°C冷冻琥珀色小瓶，对光和湿气敏感。存放在冰箱中

ATFB, SE 实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:126695-58-7试剂,126695-58-7杂质,126695-58-7合成,126695-58-7中间体,126695-58-7密度,126695-58-7溶解度,126695-58-7旋光度,126695-58-7闪点,126695-58-7熔点,126695-58-7购买,

产品说明	N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)是一种有效的不可降解的ADC连接桥，用于抗体药物结合物 (ADCs) 的合成
Introduction	N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)is a noncleavableADC linkerused in the synthesis of antibodyrug conjugates (ADCs).
Application1
Application2
Application3

N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)药理学：

N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)是一种不可降解 (non-cleavable) 的 ADC linker，N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸用于抗体偶联药物 (ADCs) 的合成。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

4-N3Pfp-NHS ester 126695-58-7)危害标识：

象形图


信号	Warning
GHS危险说明	The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
	H228 (100%): Flammable solid [Danger Flammable solids]
	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
	H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
防范说明代码	P210, P240, P241, P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, and P370+P378
	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Pyrene fluorescence quenching by aromatic azides Kinetics and Catalysis 2006

Tri- and Tetravalent Photoactivable Cross-Linking Agents Synthesis 2012 10.1055/s-0031-1290444

UV crosslinking of PVDF-based polymers for gate dielectric insulators of organic thin film transistors 2018-08-17，CN-110838546-A

Uv crosslinking of pvdf-based polymers for gate dielectric insulators of organic thin-film transistors 2018-08-17，WO-2020036761-A1

Array of polymeric hydrogel nanostructures and their uses 2018-08-06，WO-2020033227-A2

N -琥珀酰亚胺4 -叠氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)参考文献：

1、Pyrene fluorescence quenching by aromatic azides
S. V. Kamyshan, S. V. Litvinchuk, V. V. Korolev, S. I. Eremenko, Yu. P. Tsentalovich & N. P. Gritsan

Abstract Pyrene fluorescence quenching by phenylazide derivatives with donor and acceptor substituents has been studied by fluorescence spectroscopy and flash photolysis. The rate constants of quenching (k q) in acetonitrile ((0.2–1.2) × 1010 l mol−1 s−1) are found to be close to a diffusion limit; the rate constants were somewhat higher for perfluoro-substituted arylazides. It is found that k q does not depend on solvent polarity; the formation of the pyrene cation in the course of pyrene fluorescence quenching by tolylazide was not detected. Pyrene fluorescence quenching occurred by an energy-transfer mechanism; this is supported by the coincidence of the quantum yields of the direct and sensitized photodecomposition of tolylazide. As estimated, energy transfer in rigid media occurs at characteristic distances of about 10 Å.

2、Tri- and Tetravalent Photoactivable Cross-Linking Agents
Alexandre Welle, François Billard, Jacqueline Marchand-Brynaert*

Abstract A modular synthesis of photoactivable cross-linking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Symmetrical and nonsymmetrical trivalent structures were obtained from phloroglucinol and dopamine, respectively. Symmetrical tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride.

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