1310455-86-7|GNF179 Metabolite|GNF179 Metabolite|MFCD22690265-范德生物科技公司

GNF179 Metabolite

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names：
GNF179 Metabolite
CAS号：
1310455-86-7
MDL Number： MFCD22690265
MF(分子式)： C14H16FN3 MW(分子量)： 245.3
EINECS: Reaxys Number:
Pubchem ID:57521783 Brand:BIOFOUNT

GNF179 Metabolite(1310455-86-7)是GNF179的代谢物，GNF179 Metabolite是一种经过优化的8,8-二甲基IP类似物，GNF179 Metabolite具有良好的体外代谢稳定性和体内口服生物相容性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000850-5mg	5mg	>95%	¥ 3295.00	¥ 3295.00		Backorder	- +	¥ 0.00
YZM000850-2mg	2mg	>95%	¥ 2116.00	¥ 2116.00		Backorder	- +	¥ 0.00

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中文别名	GNF179 Metabolite(1310455-86-7);GNF179代谢物;GNF179 (Metabolite);GNF-179 Metabolite
英文别名	GNF179 Metabolite,1310455-86-7
CAS号	1310455-86-7
SMILES	CC1(C2=NC(C3=CC=C(F)C=C3)=CN2CCN1)C
Inchi	InChI=1S/C14H16FN3/c1-14(2)13-17-12(9-18(13)8-7-16-14)10-3-5-11(15)6-4-10/h3-6,9,16H,7-8H2,1-2H3
InchiKey	GZVLWGZMELYUPG-UHFFFAOYSA-N
分子式 Formula	C14H16FN3
分子量 Molecular Weight	245.3
闪点 FP	213.0±27.3 °C
熔点 Melting point	No data available
沸点 Boiling point	428.6±40.0 °C at 760 mmHg
Polarizability极化度	27.6±0.5 10-24cm3
密度 Density	1.2±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.0 mmHg at 25°C
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	请根据产品建议的存储条件进行存储,Please store the product under the recommended condition sin the description.

GNF179 Metabolite(1310455-86-7)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

GNF179 Metabolite(1310455-86-7) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:GNF179 Metabolite(1310455-86-7),GNF179 Metabolite试剂,GNF179 Metabolite的纯度,GNF179 Metabolite的作用,GNF179 Metabolite抑制剂,GNF179 Metabolite的合成,GNF179 Metabolite的MSDS,GNF179 Metabolite的厂家,GNF179 Metabolite的价格

产品说明	GNF179 Metabolite(1310455-86-7)是GNF179的代谢物,GNF179 Metabolite具有良好的体外代谢稳定性和体内口服生物相容性。
Introduction	GNF179 Metabolite (1310455-86-7) is a metabolite of GNF179. GNF179 Metabolite has good metabolic stability in vitro and oral biocompatibility in vivo.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.

Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.

The Molting Biomarker Metabolite N-acetylglucosamino-1,5-lactone in Female Urine of the Helmet Crab Telmessus cheiragonus.

Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.
Perna AF1, Di Nunzio A2, Amoresano A3, Pane F3, Fontanarosa C3, Piero P3, Vigorito C4, Cirillo G2, Zacchia M2, Trepiccione F2, Ingrosso D4. Biochimie. 2016 Apr 26. pii: S0300-9084(16)30071-2. doi: 10.1016/j.biochi.2016.04.018. [Epub ahead of print]
Abstract:Dialysis patients display a high cardiovascular mortality, the causes of which are still not completely explained, but are related to uremic toxicity. Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine β-synthase and cystathionine γ-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production. Hydrogen sulfide is involved in the modulation of multiple pathophysiological responses. In uremia, we have demonstrated low plasma total hydrogen sulfide levels, due to reduced cystathionine γ-lyase expression. Plasma hydrogen sulfide levels were measured in hemodialysis patients and healthy controls with three different techniques in comparison, allowing to discern the different pools of this gas. The protein-bound (the one thought to be the most active) and acid-labile forms are significantly decreased, while homolanthionine, but especially lanthionine, accumulate in the blood of uremic patients.

Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.
Tian X1, Gao Y1, Xu Z2, Lian S3, Ma Y3, Guo X1, Hu P1, Li Z1, Huang C1. Biofactors. 2016 Apr 30. doi: 10.1002/biof.1291. [Epub ahead of print]
Abstract:Mangiferin (MGF), a glucoside of xanthone existing in phytomedicines and food, is increasingly attracting attention on diabetes treatment, while the underlying mechanism leading to its low oral bioavailability is unclear. Norathyriol (NTR), an active metabolite with hypoglycemic activity and its exposure after MGF dosing remains unclear. Hence, a rapid and sensitive LC-MS/MS method was established and validated to determine MGF and NTR and applied in the PK study in rats. Correspondingly, the in vitro experiments on temperature-dependent uptake, and MGF metabolism in hepatocyte and enterobacteria samples were performed. Results revealed that hepatic first-pass effect slightly contributed to the poor bioavailability of MGF, based on the MGF exposure in portal vein plasma was nearly similar to that in systemic plasma, and the MGF accumulation in the liver was limited, so was that of NTR. Correspondingly, the in vitro study revealed the MGF uptake was mainly dependent on poor passive transport, possibly leading to its limited hepatic metabolism and accumulation.

The Molting Biomarker Metabolite N-acetylglucosamino-1,5-lactone in Female Urine of the Helmet Crab Telmessus cheiragonus.
Yano H1, Kamio M2, Nagai H1. Biol Bull. 2016 Apr;230(2):143-151.
Abstract:N-acetylglucosamino-1,5-lactone (NAGL) is a molting biomarker in the blue crab Callinectes sapidus The concentration of this compound in urine is highest at the premolt stage. Since sexually mature premolt females release sex pheromone in their urine, NAGL is a candidate sex pheromone molecule in C. sapidus This compound has not been reported in other species. In the present study, we quantified the concentration of NAGL in the urine of the helmet crab Telmessus cheiragonus, using nuclear magnetic resonance spectroscopy, and found that the concentration increases toward the day of molting and decreases after molting. However, the total amount of NAGL collected from individual animals was greatest two to five days after molting, because the amount of urine collected was the lowest at the premolt stage, and it increased after molting. The highest median concentration of NAGL in T. cheiragonas was 29 μmol l-1, which is 75% of the highest concentration reported in C.

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