1062243-51-9|Ro3280|Ro3280, Polo-like Kinase (PLK) 抑制剂|-范德生物科技公司

Ro3280

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names：
Ro3280, Polo-like Kinase (PLK) 抑制剂
CAS号：
1062243-51-9
MDL Number：
MF(分子式)： C27H35F2N7O3 MW(分子量)： 543.61
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

RO3280（PLK1 抑制剂，1062243-51-9 ）也称为 Ro5203280，是一种有效的选择性 PLK 1 抑制剂，具有出色的体外细胞效力。Ro3280 (1062243-51-9)is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).

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询价

中文别名	RO3280; RO-3280; RO 3280; Ro5203280; Ro-5203280; Ro 5203280；PLK1抑制剂；PLK1 抑制剂
英文别名	Ro3280；PLK1 inhibitor
CAS号	1062243-51-9
SMILES	O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C(OC)=C2
Inchi	InChI=1S/C27H35F2N7O3/c1-34-12-10-18(11-13-34)31-24(37)17-8-9-20(22(14-17)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9,14-15,18-19H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33)
InchiKey	DJNZZLZKAXGMMC-UHFFFAOYSA-N
分子式 Formula	C27H35F2N7O3
分子量 Molecular Weight	543.61
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	Solid power
储藏条件 Storage conditions	0 - 4 C for short term (days to weeks), or -20 C for long term (months).

RO3280（PLK1 抑制剂，1062243-51-9 ）的应用：
RO3280, also known as Ro5203280, is a potent and selective PLK 1 inhibitor with excellent in vitro cellular potency. RO3280 showed strong antitumor activity in xenograft mouse models. he 50% inhibitory concentration (IC50) of RO3280 for acute leukemia cells was between 74 and 797 nM. The IC50 of RO3280 in primary acute lymphocytic leukemia (ALL) and AML cells was between 35.49 and 110.76 nM and 52.80 and 147.50 nM, respectively. RO3280 induced apoptosis and cell cycle disorder in leukemia cells. RO3280 treatment regulated several apoptosis-associated genes. Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs.

产品说明	RO3280，1062243-51-9 也称为 Ro5203280，是一种有效的选择性 PLK 1 抑制剂，具有出色的体外细胞效力。
Introduction	RO3280, 1062243-51-9 also known as Ro5203280, is a potent and selective PLK 1 inhibitor with excellent in vitro cellular potency.
Application1
Application2
Application3

警示图
危险性
危险性警示
安全声明	H302 H410
安全防护	P264 P270 P273 P301+P312 P330 P391 P501
备注

HS Tariff Code: 2934.99.9001

1. Chen, S., Bartkovitz, D., Cai, J., et al. Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg. Med. Chem. Lett. 22(2), 1247-1250 (2012).

2. Tao, Y.-F., Li, Z.-H., Du, W.-W., et al. Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation. Oncol. Rep. 37(3), 1419-1429

3. Chen S, et al. Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1247-50.

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