2009-64-5|新蝶呤|D-(+)-Neopterin|MFCD00042801-范德生物科技公司

新蝶呤

NMR下载 COA and HPLC MSDS下载
names：
D-(+)-Neopterin
CAS号：
2009-64-5
MDL Number： MFCD00042801
MF(分子式)： C9H11N5O4 MW(分子量)： 253
EINECS:217-924-7 Reaxys Number:
Pubchem ID:135398721 Brand:BIOFOUNT

新蝶呤(2009-64-5,D-(+)-Neopterin)是一种衍生自GTP的吡嗪并嘧啶化合物，新蝶呤是四氢生物蝶呤的前体，可以用作指示细胞增殖的生化标记。新蝶呤是响应干扰素-γ刺激而合成的，并用作T辅助细胞诱导的免疫激活的标志物。新蝶呤也是氧化应激的指标，并调节活性氧（ROS）的作用。

货品编码	规格	纯度	价格 (¥)	现价(¥)	库存描述	数量	总计 (¥)
BSH63450-1g	1g	95%	¥ 0.00	¥ 0.00	Get quote	- +	¥ 0.00
BSH63450-500mg	500mg	95%	¥ 0.00	¥ 0.00	Get quote	- +	¥ 0.00
BSH63450-100mg	100mg	95%	¥ 920.00	¥ 920.00	2-3days	- +	¥ 0.00
BSH63450-20mg	20MG	95%	¥ 272.00	¥ 272.00	2-3days	- +	¥ 0.00
BSH63450-5MG	5MG	95%	¥ 158.00	¥ 158.00	2-3days	- +	¥ 0.00

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中文别名	新蝶呤(2009-64-5,D-(+)-Neopterin);D-赤型新蝶呤;新喋呤;D-新蝶呤;D-新蝶呤[D-赤式-新蝶呤]
英文别名	D-(+)-Neopterin(2009-64-5);neopterin;D-Neopterin;D-erythro-Neopterin;L-Neopterin
CAS号	2009-64-5
SMILES	c1c(nc2c(=O)[nH]c(nc2n1)N)[C@@H]([C@@H](CO)O)O
Inchi	InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
InchiKey	BMQYVXCPAOLZOK-XINAWCOVSA-N
分子式 Formula	C9H11N5O4
分子量 Molecular Weight	253
闪点 FP	375.7±34.3 °C
熔点 Melting point	>232°C
沸点 Boiling point	697.7±65.0 °C at 760 mmHg
Polarizability极化度	22.4±0.5 10-24cm3
密度 Density	2.0±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±2.3 mmHg at 25°C
溶解度Solubility
性状	白色至灰白色固体粉末
储藏条件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

新蝶呤(2009-64-5,D-(+)-Neopterin)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

D-(+)-Neopterin(2009-64-5) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:新蝶呤(2009-64-5,D-(+)-Neopterin),新蝶呤的作用,新蝶呤试剂,新蝶呤的纯度,新蝶呤的外观,新蝶呤的合成路线,新蝶呤的厂家,新蝶呤的溶解度,新蝶呤的使用,新蝶呤的价格,新蝶呤的MSDS,新蝶呤的注意事项

产品说明	新蝶呤(2009-64-5,D-(+)-Neopterin) 是三磷酸腺苷的分解产物，新蝶呤可以作为细胞免疫系统激活的标志物。
Introduction	D-(+)-Neopterin(2009-64-5,新蝶呤) is a breakdown product of adenosine triphosphate, and neopterin can be used as a marker of cellular immune system activation.
Application1	新蝶呤(2009-64-5,D-(+)-Neopterin)可以用作指示细胞增殖的生化标记。
Application2	新蝶呤(2009-64-5,D-(+)-Neopterin)用作T辅助细胞诱导的免疫激活的标志物。
Application3	新蝶呤还用作生物蝶呤生物合成中的前体。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

象形图
信号	Warning
GHS危险说明	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

The prognostic role of neopterin in COVID-19 patients(Journal of medical virology,2020)

Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study(Journal of Polymer Research,2019)

Serum neopterin level in cases of pulmonary tuberculosis and pneumonia(Egyptian Journal of Bronchology,2016)

Role of IL-6 and neopterin in the pathogenesis of herpetic encephalitis(Pharmacological Reports2011)

Urinary neopterin, a new marker of the neuroinflammatory status in amyotrophic lateral sclerosis(Journal of Neurology,2020)

1.Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis.
Cinici E;Palabiyik SS;Sipahi H;Baydar T Int Ophthalmol. 2017 Aug 4. doi: 10.1007/s10792-017-0669-1. [Epub ahead of print]
PURPOSE: ;The study aims to evaluate changes in neopterin levels and tryptophan degradation which are induced by Th1-type immune response and nitric oxide metabolism which may be involved in allergic inflammation.;METHODS: ;Serum nitrite, kynurenine, tryptophan and neopterin levels were evaluated in 36 patients with seasonal allergic conjunctivitis, along with these values in 41 healthy subjects. All these parameters have been compared with symptom and sign scores.;RESULTS: ;Tryptophan and kynurenine concentrations were not significantly changed, while serum nitrite concentrations were significantly low, and neopterin levels were significantly increased in patients compared to healthy subjects (p < 0.05). There was a significant relationship between symptom scores and serum nitrite levels in patients.;CONCLUSIONS: ;This preliminary study demonstrates that serum nitric oxide metabolism might have a role in allergic conjunctivitis. Serum neopterin levels but not tryptophan metabolism could serve as a biomarker in patients with seasonal allergic conjunctivitis.

2.Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor.
Klatt P;Heinzel B;Mayer B;Ambach E;Werner-Felmayer G;Wachter H;Werner ER FEBS Lett. 1992 Jun 29;305(2):160-2.
To check the stimulatory potency of the tetrahydro forms of the two major pteridines occurring in human tissues, neopterin and biopterin, NO synthase was purified 6000-fold from human cerebellum. Tetrahydrobiopterin stimulated the activity up to 4.5-fold in a concentration dependent manner with a maximum above 1 microM, whereas tetrahydroneopterin was completely inactive in concentrations up to 100 microM. Tetrahydrobiopterin, but not neopterin derivatives, were copurified with the NO synthase activity. Our results demonstrate that human cerebellum contains a tetrahydrobiopterin dependent NO synthase activity.

3.Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia.
Ohta E;Funayama M;Ichinose H;Toyoshima I;Urano F;Matsuo M;Tomoko N;Yukihiko K;Yoshino S;Yokoyama H;Shimazu H;Maeda K;Hasegawa K;Obata F Arch Neurol. 2006 Nov;63(11):1605-10.
OBJECTIVES: ;To better understand the relationship between mutation of the guanosine triphosphate cyclohydrolase I (GCH1) gene and the etiology of DYT5 dystonia and to accumulate data on the mutation in the Japanese population for genetic diagnosis of the disease.;SETTING: ;Japanese population. Patients Eight Japanese patients with suspected DYT5 dystonia were analyzed. Intervention Direct genomic sequencing of 6 exons of GCH1 was performed.;MAIN OUTCOME MEASURES: ;For patients who did not exhibit any abnormality in the sequence analysis, the possibility of exon deletions was examined. In cases for which cerebrospinal fluid was available, the concentrations of neopterin and biopterin were measured as an index of GCH1 enzyme activity.;RESULTS: ;In 2 patients, we found a new T106I mutation in exon 1 of GCH1, a position involved in the helix-turn-helix structure of the enzyme. In the third patient, we found a new mutation (a 15-base pair nucleotide deletion) in exon 5 that may cause a frameshift involving the active site. In the fourth patient, we detected a known nucleotide G>A substitution in the splice site of intron 5, which has been reported to produce exon 5-skipped messenger RNA.

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