4434-05-3|Coumermycin|Coumermycin|-范德生物科技公司

Coumermycin

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names：
Coumermycin
CAS号：
4434-05-3
MDL Number：
MF(分子式)： C55H59N5O20 MW(分子量)： 1110.092
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	[(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-4-methyl-1H-pyrrole-3-carbonyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate
英文别名	Coumermycin
CAS号	4434-05-3
Inchi	InChI=1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1
InchiKey	WTIJXIZOODAMJT-DHFGXMAYSA-N
分子式 Formula	C55H59N5O20
分子量 Molecular Weight	1110.092
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Coumermycin(CAS:4434-05-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Coumermycin is an antibacterial agent effective against Staphylococcus aureus and Staphylococcus epidermidis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kincade JM, deHaseth PL. Bacteriophage lambda promoters pL and pR: sequence determinants of in vivo activity and of sensitivity to the DNA gyrase inhibitor, coumermycin. Gene. 1991 Jan 2;97(1):7-12. PubMed PMID: 1847348.

[2]Vanden Broeck A, McEwen AG, Chebaro Y, Potier N, Lamour V. Structural Basis for DNA Gyrase Interaction with Coumermycin A1. J Med Chem. 2019 Apr 25;62(8):4225-4231. doi: 10.1021/acs.jmedchem.8b01928. Epub 2019 Apr 3. PubMed PMID: 30920824.

[3] Xu H, Wang ZX, Schmidt J, Heide L, Li SM. Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin. Mol Genet Genomics. 2002 Nov;268(3):387-96. Epub 2002 Oct 11. PubMed PMID: 12436260.

[4] Novotna J, Gust B, Kulik A, Spizek J, Heide L. Five gene products are required for assembly of the central pyrrole moiety of coumermycin A1. J Ind Microbiol Biotechnol. 2013 Aug;40(8):915-25. doi: 10.1007/s10295-013-1266-6. Epub 2013 May 8. PubMed PMID: 23652970.

[5] Cele FN, Kumalo H, Soliman ME. Mechanism of Inhibition of Hsp90 Dimerization by Gyrase B Inhibitor Coumermycin A1 (C-A1) Revealed by Molecular Dynamics Simulations and Thermodynamic Calculations. Cell Biochem Biophys. 2016 Sep;74(3):353-63. doi: 10.1007/s12013-016-0743-8. Epub 2016 Jul 4. PubMed PMID: 27376828.

6: Pacholec M, Tao J, Walsh CT. CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. Biochemistry. 2005 Nov 15;44(45):14969-76. PubMed PMID: 16274243.7: Schmutz E, Steffensky M, Schmidt J, Porzel A, Li SM, Heide L. An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. Eur J Biochem. 2003 Nov;270(22):4413-9. PubMed PMID: 14622269.8: Garneau-Tsodikova S, Stapon A, Kahne D, Walsh CT. Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. Biochemistry. 2006 Jul 18;45(28):8568-78. PubMed PMID: 16834331.9: Perronne CM, Malinverni R, Glauser MP. Treatment of Staphylococcus aureus endocarditis in rats with coumermycin A1 and ciprofloxacin, alone or in combination. Antimicrob Agents Chemother. 1987 Apr;31(4):539-43. PubMed PMID: 3606060; PubMed Central PMCID: PMC174774.10: Neu HC, Chin NX, Labthavikul P. Antibacterial activity of coumermycin alone and in combination with other antibiotics. Antimicrob Agents Chemother. 1984 Jun;25(6):687-9. PubMed PMID: 6331295; PubMed Central PMCID: PMC185623.1

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