138490-53-6|WAY-123398 free base|N-methyl-N-(2-(methyl(1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-4-(methylsulfonamido)benzenesulfonamide|-范德生物科技公司

WAY-123398 free base

NMR下载 COA and HPLC MSDS下载
names：
N-methyl-N-(2-(methyl(1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-4-(methylsulfonamido)benzenesulfonamide
CAS号：
138490-53-6
MDL Number：
MF(分子式)： C19H25N5O4S MW(分子量)： 451.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	N-methyl-N-(2-(methyl(1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-4-(methylsulfonamido)benzenesulfonamide
英文别名	Way123398; Way-123398; Way 123398; Way-123,398; Way123,398; Way 123,398
CAS号	138490-53-6
Inchi	InChI=1S/C19H25N5O4S2/c1-22(19-20-17-7-5-6-8-18(17)24(19)3)13-14-23(2)30(27,28)16-11-9-15(10-12-16)21-29(4,25)26/h5-12,21H,13-14H2,1-4H3
InchiKey	PELVIWZRAPOYAC-UHFFFAOYSA-N
分子式 Formula	C19H25N5O4S
分子量 Molecular Weight	451.56
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	WAY-123398 free base(CAS:138490-53-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Way 123398 is a class III antiarrhythmic agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Liang XJ, Taylor B, Cardarelli C, Yin JJ, Annereau JP, Garfield S, Wincovitch S, Szakács G, Gottesman MM, Aszalos A. Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance. Anticancer Res. 2005 Nov-Dec;25(6B):4113-22. PubMed PMID: 16309205.

[2]Finlayson K, Turnbull L, January CT, Sharkey J, Kelly JS. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen. Eur J Pharmacol. 2001 Oct 26;430(1):147-8. PubMed PMID: 11698075.

[3] Higashida H, Brown DA, Robbins J. Both linopirdine- and WAY123,398-sensitive components of I K(M,ng) are modulated by cyclic ADP ribose in NG108-15 cells. Pflugers Arch. 2000 Dec;441(2-3):228-34. PubMed PMID: 11211107.

[4] Finlayson K, Pennington AJ, Kelly JS. [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel? Eur J Pharmacol. 2001 Feb 2;412(3):203-12. PubMed PMID: 11166283.

[5] Lee JH, Rosen MR. Alpha 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J Cardiovasc Electrophysiol. 1994 Mar;5(3):232-40. PubMed PMID: 8193739.

6: Spinelli W, Moubarak IF, Parsons RW, Colatsky TJ. Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes. Cardiovasc Res. 1993 Sep;27(9):1580-91. PubMed PMID: 8287434.7: Ellingboe JW, Spinelli W, Winkley MW, Nguyen TT, Parsons RW, Moubarak IF, Kitzen JM, Von Engen D, Bagli JF. Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides. J Med Chem. 1992 Feb 21;35(4):705-16. PubMed PMID: 1542097.8: Gullo F, Ales E, Rosati B, Lecchi M, Masi A, Guasti L, Cano-Abad MF, Arcangeli A, Lopez MG, Wanke E. ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J. 2003 Feb;17(2):330-2. Epub 2002 Dec 17. PubMed PMID: 12490549.9: Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, Olivotto M, Pegoraro L, Arcangeli A. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia. 2002 Sep;16(9):1791-8. PubMed PMID: 12200695.10: Cherubini A, Taddei GL, Crociani O, Paglierani M, Buccoliero AM, Fontana L, Noci I, Borri P, Borrani E, Giachi M, Becchetti A, Rosati B, Wanke E, Olivotto M, Arcangeli A. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br J Cancer. 2000 Dec;83(12):1722-9. PubMed PMID: 11104572; PubMed Central PMCID: PMC2363441.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开