123286-00-0|Vinfosiltine|Vinfosiltine|-范德生物科技公司

Vinfosiltine

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names：
Vinfosiltine
CAS号：
123286-00-0
MDL Number：
MF(分子式)： C51H72N5O10P MW(分子量)： 946.13
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl (5S,7R,9S)-9-((3aR,3a1R,4R,5S,5aR,10bR)-5-(((S)-1-(diethoxyphosphoryl)-2-methylpropyl)carbamoyl)-3a-ethyl-4,5-dihydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl)-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indole-9-carboxylate
英文别名	Vinfosiltine; S12363; S 12363; S-12363;
CAS号	123286-00-0
Inchi	InChI=1S/C51H72N5O10P/c1-10-47(60)27-32-28-50(46(59)64-9,40-34(19-23-55(29-32)30-47)33-17-14-15-18-37(33)52-40)36-25-35-38(26-39(36)63-8)54(7)43-49(35)21-24-56-22-16-20-48(11-2,42(49)56)44(57)51(43,61)45(58)53-41(31(5)6)67(62,65-12-3)66-13-4/h14-18,20,25-26,31-32,41-44,52,57,60-61H,10-13,19,21-24,27-30H2,1-9H3,(H,53,58)/t32-,41-,42-,43+,44+,47-,48+,49+,50-,51-/m0/s1
InchiKey	BOELCLFVOBIXIF-MAKKXPIGSA-N
分子式 Formula	C51H72N5O10P
分子量 Molecular Weight	946.13
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Vinfosiltine(CAS:123286-00-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Vinfosiltine is an antineoplastic agent which belongs to the vinca alkaloid group incorporating an amino-phosphonate.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Pierré A, Kraus-Berthier L, Atassi G, Cros S, Poupon MF, Lavielle G, Berlion M, Bizzari JP. Preclinical antitumor activity of a new Vinca alkaloid derivative, S 12363. Cancer Res. 1991 May 1;51(9):2312-8. PubMed PMID: 2015595.

[2]Wright M, Garès M, Verdier-Pinard P, Moisand A, Berlion M, Legrand JJ, Bizzari JP. Differential in vitro action of S-12363, a new vinblastine derivative, and of its epimer on microtubule proteins. Cancer Chemother Pharmacol. 1991;28(6):434-40. PubMed PMID: 1934248.

[3] Berlion M, Arvelo F, Leonce S, Bourgeois Y, Rigaudy P, Bizzari JP, Poupon MF. Antitumor activity of the new vinca-alkaloid S 12363 alone or in combination with verapamil on a human multidrug resistant renal carcinoma xenograft. In Vivo. 1993 Sep-Oct;7(5):399-405. PubMed PMID: 7906553.

[4] Lelievre E, Guillaudeux J, Cardona H, Bourguignat A, Lokiec F, Solere P, Lucas C, Sauveur C. Human pharmacokinetics of a new Vinca alkaloid S 12363 with use of a monoclonal antibody-based radio- or enzyme immunoassay. Cancer Res. 1993 Aug 1;53(15):3536-40. PubMed PMID: 8339259.

[5] Atassi G, Berlion M, el Oche Y, Bizzari JP. Characterization of the pharmacological antitumor effects of S 12363, a new vinca alkaloid. Anticancer Res. 1991 Mar-Apr;11(2):975-80. PubMed PMID: 2064354.

6: Fischel JL, Berlion M, Formento P, Bizzari JP, Milano G. Evaluation of the time-schedule dependency for the cytotoxic activity of the new vinca alkaloid derivative, S 12363 (vinfosiltine). Eur J Cancer. 1993;29A(13):1890-4. PubMed PMID: 8260248.7: Gordon BH, Bakes DM, Bennett P, LeBras B, Walther B, Lucas C, Marc S, Gouyette A. Methods for the analysis of the new vinca alkaloid derivative, S 12363, in plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):163-71. PubMed PMID: 7952064.8: Pierré A, Lavielle G, Hautefaye P, Seurre G, Leonce S, Saint-Dizier D, Boutin JA, Cudennec CA. Pharmacological properties of a new alpha-aminophosphonic acid derivative of vinblastine. Anticancer Res. 1990 Jan-Feb;10(1):139-44. PubMed PMID: 2334119.9: Pierré A, Pérez V, Léonce S, Boutin JA, Saint-Dizier D, Hautefaye P, Lavielle G, Atassi G. Relationship between the cellular accumulation and the cytotoxicity of S12363, a new Vinca alkaloid derivative. Cancer Chemother Pharmacol. 1992;29(5):367-74. PubMed PMID: 1551175.10: Budman DR. New vinca alkaloids and related compounds. Semin Oncol. 1992 Dec;19(6):639-45. Review. PubMed PMID: 1462165.1

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