6138-79-0|Triprolidine HCl|2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride|-范德生物科技公司

Triprolidine HCl

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names：
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride
CAS号：
6138-79-0
MDL Number：
MF(分子式)： C19H23ClN2 MW(分子量)： 314.857
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride
英文别名	Triprolidine HCl; Actidilat; Pro-Actidil; Pro-Entra; Venen; Entra; Actidilon.
CAS号	6138-79-0
Inchi	InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InchiKey	WYUYEJNGHIOFOC-NWBUNABESA-N
分子式 Formula	C19H23ClN2
分子量 Molecular Weight	314.857
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Triprolidine HCl(CAS:6138-79-0 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many antihistamines, the most common side effect is drowsiness. Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15–30 minutes. .
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危险性	Warning
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备注

[1]Xuan X, Huang L, Pan X, Li N. [Simultaneous determination of five cold medicine ingredients in paracetamol triprolidine hydrochloride and pseudoephedrine hydrochloride tablets by pH/organic solvent double-gradient high performance liquid chromatography]. Se Pu. 2013 Feb;31(2):133-8. Chinese. PubMed PMID: 23697177.

[2]Dev R, Kumar A, Pathak K. Solubility-modulated asymmetric membrane tablets of triprolidine hydrochloride: statistical optimization and evaluation. AAPS PharmSciTech. 2012 Mar;13(1):174-83. doi: 10.1208/s12249-011-9738-3. Epub 2011 Dec 20. PubMed PMID: 22183255; PubMed Central PMCID: PMC3299447.

[3] Sandhya B, Hegde AH, Kalanur SS, Katrahalli U, Seetharamappa J. Interaction of triprolidine hydrochloride with serum albumins: thermodynamic and binding characteristics, and influence of site probes. J Pharm Biomed Anal. 2011 Apr 5;54(5):1180-6. doi: 10.1016/j.jpba.2010.12.012. Epub 2010 Dec 16. PubMed PMID: 21215548.

[4] Manassra A, Khamis M, El-Dakiky M, Abdel-Qader Z, Al-Rimawi F. Simultaneous HPLC analysis of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid dosage forms. J Pharm Biomed Anal. 2010 Mar 11;51(4):991-3. doi: 10.1016/j.jpba.2009.10.024. Epub 2009 Nov 10. PubMed PMID: 19954915.

[5] Shakya AK, Arafat TA, Abuawwad AN, Melhim M, Al-Ghani J, Yacoub MJ. Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 15;877(32):4071-8. doi: 10.1016/j.jchromb.2009.10.021. Epub 2009 Oct 31. PubMed PMID: 19926351.

6: Kandimalla KK, Donovan MD. Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. Int J Pharm. 2005 Sep 30;302(1-2):133-44. PubMed PMID: 16105724.7: Shin SC, Choi JS. Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats. Eur J Pharm Biopharm. 2005 Sep;61(1-2):14-9. PubMed PMID: 16005195.8: Zayed SI, Habib IH. Adsorptive stripping voltammetric determination of triprolidine hydrochloride in pharmaceutical tablets. Farmaco. 2005 Jun-Jul;60(6-7):621-5. PubMed PMID: 15950226.9: Shin SC, Choi JS. Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats. Arch Pharm Res. 2005 Jan;28(1):111-4. PubMed PMID: 15742818.10: Zayed SI. New plastic membrane and carbon paste ion selective electrodes for the determination of triprolidine. Anal Sci. 2004 Jul;20(7):1043-8. PubMed PMID: 15293399.1

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