129927-33-9|Temiverine hydrochloride|5-(diethylamino)-2-methylpent-3-yn-2-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride|-范德生物科技公司

Temiverine hydrochloride

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names：
5-(diethylamino)-2-methylpent-3-yn-2-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride
CAS号：
129927-33-9
MDL Number：
MF(分子式)： C24H36ClNO3 MW(分子量)： 422.006
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	5-(diethylamino)-2-methylpent-3-yn-2-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride
英文别名	NS-21; NS 21; NS21; Temiverine. CCRIS 7921; Brande name Urespan.
CAS号	129927-33-9
Inchi	InChI=1S/C24H35NO3.ClH/c1-5-25(6-2)19-13-18-23(3,4)28-22(26)24(27,20-14-9-7-10-15-20)21-16-11-8-12-17-21;/h7,9-10,14-15,21,27H,5-6,8,11-12,16-17,19H2,1-4H3;1H
InchiKey	JQCLFZVNMLALLU-UHFFFAOYSA-N
分子式 Formula	C24H36ClNO3
分子量 Molecular Weight	422.006
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Temiverine hydrochloride(CAS:129927-33-9 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Temiverine, also known as NS-21, is an anticholinergic drug with calcium antagonistic activity for the treatment of urinary frequency and urinary incontinence. NS-21 increases bladder capacity at lower doses in hypogastric nerve-transected rats than in sham-operated rats. NS-21 increases the bladder capacity without suppressing micturition pressure, suggesting that NS-21 may be a more effective therapeutic drug than propiverine, oxybutynin or flavoxate for the treatment of urinary frequency and urinary incontinence.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nakamura A, Hirota T, Morino A, Imaoka S, Funae Y, Yamamoto Y, Tasaki T, Masuda M, Kazusaka A, Fujita S. Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-2[1]Xenobiotica. 1999 Mar;29(3):243-52. PubMed PMID: 10219965.

[2]Natsukawa T, Matsuzaki T, Hayashi S, Ukai Y, Yoshikuni Y, Kimura K. Comparison of the effects of NS-21 and terodiline on the QTc interval in dogs. Gen Pharmacol. 1998 Jan;30(1):137-42. PubMed PMID: 9457495.

[3] Hamada K, Sasaki Y, Taniguchi N, Fukui H, Miyatsuka Y, Kimura Y, Ukai Y, Yoshikuni Y, Kimura K. Anticholinergic and calcium antagonistic activities of NS-21 contribute to the inhibition of rat urinary bladder contractions. Gen Pharmacol. 1997 Nov;29(5):771-8. PubMed PMID: 9347324.

[4] Sasaki Y, Hamada K, Yamazaki C, Seto T, Kimura Y, Ukai Y, Yoshikuni Y, Kimura K. Effect of NS-21, an anticholinergic drug with calcium antagonistic activity, on lower urinary tract function in a rat model of urinary frequency. Int J Urol. 1997 Jul;4(4):401-6. PubMed PMID: 9256331.

[5] Hayashi S, Natsukawa T, Ukai Y, Yoshikuni Y, Kimura K. Inhibitory effects of NS-21, a novel drug for urinary incontinence, and its active metabolite, RCC-36, on L-type calcium currents in isolated guinea pig detrusor smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 1997 May;355(5):659-66. PubMed PMID: 9151307.

6: Hayashi S, Natsukawa T, Suma C, Ukai Y, Yoshikuni Y, Kimura K. Cardiac electrophysiological actions of NS-21 and its active metabolite, RCC-36, compared with terodiline. Naunyn Schmiedebergs Arch Pharmacol. 1997 May;355(5):651-8. PubMed PMID: 9151306.7: Okasaki K, Nagata R, Ohnishi M, Samejima H, Fujisawa H, Kimura K. [Antigenicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence]. J Toxicol Sci. 1997 Apr;22 Suppl 1:307-13. Japanese. Erratum in: J Toxicol Sci 1997 Nov;22 Suppl

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