259224-95-8|SMP-797 HCl|1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-(3-hydroxypropoxy)phenyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)urea hydrochloride|-范德生物科技公司

SMP-797 HCl

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names：
1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-(3-hydroxypropoxy)phenyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)urea hydrochloride
CAS号：
259224-95-8
MDL Number：
MF(分子式)： C34H44ClN5O4 MW(分子量)： 622.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-(3-hydroxypropoxy)phenyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)urea hydrochloride
英文别名	SMP-797; SMP797; SMP 797
CAS号	259224-95-8
Inchi	InChI=1S/C34H43N5O4.ClH/c1-6-7-15-39-32-26(13-9-14-36-32)29(23-11-8-12-25(18-23)43-17-10-16-40)31(33(39)41)38-34(42)37-30-27(21(2)3)19-24(35)20-28(30)22(4)5;/h8-9,11-14,18-22,40H,6-7,10,15-17,35H2,1-5H3,(H2,37,38,42);1H
InchiKey	FAFVVBJEQCPDIA-UHFFFAOYSA-N
分子式 Formula	C34H44ClN5O4
分子量 Molecular Weight	622.21
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SMP-797 HCl(CAS:259224-95-8 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	An ACAT (acyl-CoA-cholesterol acyltransferase) inhibitor potentially for the treatment of Hyperlipidemia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Asano S, Ban H, Kino K, Ioriya K, Muraoka M. Synthesis and structure-activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N'-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents. Bioorg Med Chem. 2009 Jul 1;17(13):4636-46. doi: 10.1016/j.bmc.2009.04.059. PubMed PMID: 19464189.

[2]Asano S, Ban H, Kino K, Ioriya K, Muraoka M. Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1062-5. doi: 10.1016/j.bmcl.2009.01.020. PubMed PMID: 19167888.

[3] Kitamura A, Imai S, Yabuki M, Komuro S. The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems. Biopharm Drug Dispos. 2007 Dec;28(9):517-25. PubMed PMID: 17918775.

[4] Ioriya K, Kino K, Horisawa S, Nishimura T, Muraoka M, Noguchi T, Ohashi N. Pharmacological profile of SMP-797, a novel acyl-coenzyme a: cholesterol acyltransferase inhibitor with inducible effect on the expression of low-density lipoprotein receptor. J Cardiovasc Pharmacol. 2006 Feb;47(2):322-9. PubMed PMID: 16495773.

[5] Ban H, Muraoka M, Ioriya K, Ohashi N. Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility. Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. PubMed PMID: 16242323.

6: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jan-Feb;27(1):49-77. PubMed PMID: 15834459.

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