116476-13-2|Sesamodil|(R)-2-(2-(3-((2-(benzo[d][1,3]dioxol-5-yloxy)ethyl)(methyl)amino)propoxy)-5-methoxyphenyl)-4-methyl-2H-benzo[b][1,4]thiazin-3(4H)-one|-范德生物科技公司

Sesamodil

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names：
(R)-2-(2-(3-((2-(benzo[d][1,3]dioxol-5-yloxy)ethyl)(methyl)amino)propoxy)-5-methoxyphenyl)-4-methyl-2H-benzo[b][1,4]thiazin-3(4H)-one
CAS号：
116476-13-2
MDL Number：
MF(分子式)： C29H32N2O6S MW(分子量)： 536.643
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(R)-2-(2-(3-((2-(benzo[d][1,3]dioxol-5-yloxy)ethyl)(methyl)amino)propoxy)-5-methoxyphenyl)-4-methyl-2H-benzo[b][1,4]thiazin-3(4H)-one
英文别名	Sesamodil; Sesamodil fumarate; SD 3211; SD-3211; SD3211; DS-4823; DS 4823; DS4823
CAS号	116476-13-2
Inchi	InChI=1S/C29H32N2O6S/c1-30(14-16-34-21-10-12-25-26(18-21)37-19-36-25)13-6-15-35-24-11-9-20(33-3)17-22(24)28-29(32)31(2)23-7-4-5-8-27(23)38-28/h4-5,7-12,17-18,28H,6,13-16,19H2,1-3H3/t28-/m1/s1
InchiKey	RKXVEXUAWGRFNP-MUUNZHRXSA-N
分子式 Formula	C29H32N2O6S
分子量 Molecular Weight	536.643
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sesamodil(CAS:116476-13-2 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sesamodil is a calcium channel antagonist potentially used for the treatment of angina pectoris and hypertension. Results suggest that Sesamodil exerts a potent and long-lasting Ca2+ antagonistic effect on isolated arteries, possessing pharmacological properties diverse from those of known Ca2+ antagonists with respect to tissue selectivity, i.e., it is more vasoselective than diltiazem and verapamil, and more cardioselective than nifedipine and nicardipine.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Morishima K, Tahara R, Horiuchi M. Determination of a new calcium antagonist, sesamodil fumarate (SD-3211), and its metabolite in plasma by liquid chromatography with electrochemical detection. J Chromatogr. 1990 May 18;527(2):381-8. PubMed PMID: 2387885.

[2]Nishimura K, Miyawaki N, Yamauchi H, Iso T. Tissue selectivity of the novel calcium antagonist sesamodil fumarate in isolated smooth muscles and cardiac muscles. Arzneimittelforschung. 1990 Mar;40(3):244-8. PubMed PMID: 2112000.

[3] Adamson PB, Vanoli E, Shibano T, Foreman RD, Schwartz PJ. Combined sodium and calcium channel blockade in prevention of lethal arrhythmias. J Cardiovasc Pharmacol. 2003 May;41(5):665-70. PubMed PMID: 12717095.

[4] Wolfram RM, Kritz H, Oguogho A, Sinzinger H. Antiplatelet activity of semotiadil fumarate. Thromb Res. 2002 May 15;106(4-5):187-90. PubMed PMID: 12297124.

[5] Tomita K, Tomidokoro A, Tamaki Y, Araie M, Matsubara M, Fukaya Y. Effects of semotiadil, a novel calcium antagonist, on the retina and optic nerve head circulation. J Ocul Pharmacol Ther. 2000 Jun;16(3):231-9. PubMed PMID: 10872920.

6: Tsuchiya Y, Ohno H, Satoh H, Sugawara T, Kajimura T, Nomura M. Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats. J Toxicol Sci. 2000 May;25(2):121-30. PubMed PMID: 10845190.7: Nakajima M, Suzuki M, Yamaji R, Takashina H, Shimada N, Yamazaki H, Yokoi T. Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds. Xenobiotica. 1999 Dec;29(12):1191-202. PubMed PMID: 10647906.8: Rodriguez Rosas ME, Shibukawa A, Yoshikawa Y, Kuroda Y, Nakagawa T. Binding study of semotiadil and levosemotiadil with alpha(1)-acid glycoprotein using high-performance frontal analysis. Anal Biochem. 1999 Oct 1;274(1):27-33. PubMed PMID: 10527493.9: Sasaki S, Nakagawa M. [Calcium channel blocker for therapy of patients with hypertension]. Nihon Rinsho. 1997 Aug;55(8):2061-6. Review. Japanese. PubMed PMID: 9284424.10: Fujiki A, Tani M, Hayashi H, Mizumaki K, Inoue H, Uemura H, Nakaya H. Electrophysiologic effects of SD-3212, a new class I antiarrhythmic drug, on canine atrial flutter and atrial action-potential characteristics. J Cardiovasc Pharmacol. 1997 Apr;29(4):471-5. PubMed PMID: 9156356.

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