59712-21-9|SC 4453|SC 4453|-范德生物科技公司

SC 4453

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names：
SC 4453
CAS号：
59712-21-9
MDL Number：
MF(分子式)： C41H64N2O12 MW(分子量)： 776.96
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(2S,3R,4S,6S)-6-(((2S,3S,4S,6R)-6-(((2R,3S,4S,6R)-6-(((3R,5R,8R,9R,10S,12S,13S,14S,17S)-12,14-dihydroxy-10,13-dimethyl-17-(pyridazin-4-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3,4-diol
英文别名	SC 4453; SC-4453; SC4453;
CAS号	59712-21-9
SMILES	O[C@H]1[C@H](C)O[C@@H](O[C@@H]2[C@H](C)O[C@H](O[C@@H]3[C@@H](C)O[C@@H](O[C@@H]4CC[C@]5(C)[C@]6([H])C[C@H](O)[C@]7(C)[C@H](C8=CC=NN=C8)CC[C@]7(O)[C@]6([H])CC[C@]5([H])C4)C[C@@H]3O)C[C@@H]2O)C[C@@H]1O
Inchi	InChI=1S/C41H64N2O12/c1-20-36(48)29(44)16-34(50-20)54-38-22(3)52-35(18-31(38)46)55-37-21(2)51-33(17-30(37)45)53-25-8-11-39(4)24(14-25)6-7-27-28(39)15-32(47)40(5)26(9-12-41(27,40)49)23-10-13-42-43-19-23/h10,13,19-22,24-38,44-49H,6-9,11-12,14-18H2,1-5H3/t20-,21+,22-,24+,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35+,36-,37+,38+,39-,40-,41-/m0/s1
InchiKey	OUDJBXKBCFRTRI-FKLSQBIHSA-N
分子式 Formula	C41H64N2O12
分子量 Molecular Weight	776.96
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SC 4453(CAS:59712-21-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SC 4453 is a digoxin analog and a cardiac glycoside derivative.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Randimbivololona F. Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins. Eur J Drug Metab Pharmacokinet. 1988 Jan-Mar;13(1):19-22. PubMed PMID: 3396609.

[2]Randimbivololona F, Lesne M. Intestinal absorption of SC4453 in the guinea-pig. Arch Int Pharmacodyn Ther. 1982 Dec;260(2):296-8. PubMed PMID: 7165435.

[3] Randimbivololona F, Lesne M. Importance of the urinary excretion in the total elimination of SC4453 in the guinea-pig. J Pharmacol. 1984 Apr-Jun;15(2):199-208. PubMed PMID: 6738077.

[4] Gupta RS, Chopra A. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453. J Biol Chem. 1985 Jun 10;260(11):6843-50. PubMed PMID: 2987235.

[5] Chopra A, Dudani AK, Gupta RS. Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides. Biochem Cell Biol. 1990 May;68(5):852-7. PubMed PMID: 2169261.

6: Randimbivololona F, Lesne M. Metabolism and excretion in bile of SC4453, a new semi-synthetic derivative of digoxin following an i.v. bolus injection in the guinea-pig. J Pharmacol. 1984 Jan-Mar;15(1):53-64. PubMed PMID: 6717027.7: Gupta RS, Chopra A, Trott AB. Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants. Biochem Pharmacol. 1989 Jul 1;38(13):2159-68. PubMed PMID: 2735954.8: Randimbivololona F, Lesne M. Comparison of the pharmacokinetic parameters of digoxin and SC4453 a digoxin analogue, following a single bolus i.v. dose and following an infusion preceeded by an i.v. loading dose in the guinea-pig. J Pharmacol. 1983 Jan-Mar;14(1):9-17. PubMed PMID: 6834854.9: Gupta RS, Chopra A. Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. Biochem Pharmacol. 1987 Nov 15;36(22):3829-33. PubMed PMID: 2825704.10: Chopra A, Gupta RS. Biochemical and cross-resistance studies with HeLa cell mutants resistant to cardiac glycoside SC4453. Regulation of the resistant form of Na+/K+-ATPase in the mutant cells. J Biol Chem. 1986 Feb 15;261(5):2034-40. PubMed PMID: 3003091.

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