197446-75-6|SB-220025 trihydrochloride|5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride|-范德生物科技公司

SB-220025 trihydrochloride

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names：
5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride
CAS号：
197446-75-6
MDL Number：
MF(分子式)： C18H22Cl3FN6 MW(分子量)： 447.7644
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride
英文别名	SB 220025 ; SB220025; SB-220025 trihydrochloride
CAS号	197446-75-6
SMILES	FC1=CC=C(C2=C(C3=NC(N)=NC=C3)N(C4CCNCC4)C=N2)C=C1.[H]Cl.[H]Cl.[H]Cl
Inchi	InChI=1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H
InchiKey	IPFBHUGKKONHFR-UHFFFAOYSA-N
分子式 Formula	C18H22Cl3FN6
分子量 Molecular Weight	447.7644
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SB-220025 trihydrochloride(CAS:197446-75-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SB-220025 trihydrochloride is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bell CE, Watson AJ. p38 MAPK regulates cavitation and tight junction function in the mouse blastocyst. PLoS One. 2013 Apr 4;8(4):e59528. doi: 10.1371/journal.pone.0059528. Print 2013. PubMed PMID: 23593143; PubMed Central PMCID: PMC3617173.

[2]Kanaji N, Nelson A, Allen-Gipson DS, Sato T, Nakanishi M, Wang X, Li Y, Basma H, Michalski J, Farid M, Rennard SI, Liu X. The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair. Inflamm Res. 2012 Mar;61(3):233-44. doi: 10.1007/s00011-011-0405-7. Epub 2011 Dec 3. PubMed PMID: 22138711.

[3] Campbell JS, Argast GM, Yuen SY, Hayes B, Fausto N. Inactivation of p38 MAPK during liver regeneration. Int J Biochem Cell Biol. 2011 Feb;43(2):180-8. doi: 10.1016/j.biocel.2010.08.002. Epub 2010 Aug 11. PubMed PMID: 20708092; PubMed Central PMCID: PMC3022113.

[4] Sharma A, Guan H, Yang K. The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability. Endocrinology. 2009 Sep;150(9):4278-86. doi: 10.1210/en.2009-0479. Epub 2009 Jun 4. PubMed PMID: 19497972.

[5] Watanabe J, Natsume T, Kobayashi M. The inhibitory effect of docetaxel and p38 MAPK inhibitor on TZT-1027 (Soblidotin)-induced antivascular activity. Anticancer Res. 2007 Nov-Dec;27(6B):3909-18. PubMed PMID: 18225550.

6: Ishii T, Sootome H, Toyoda H, Suda M, Noumi T, Yamashita K. Dual enzyme-linked immunosorbent assay system for detection of endogenous kinase activities of mitogen- and stress-activated protein kinase-1/2. Assay Drug Dev Technol. 2007 Aug;5(4):523-33. PubMed PMID: 17767420.7: Winger QA, Guttormsen J, Gavin H, Bhushan F. Heat shock protein 1 and the mitogen-activated protein kinase 14 pathway are important for mouse trophoblast stem cell differentiation. Biol Reprod. 2007 May;76(5):884-91. Epub 2007 Jan 31. PubMed PMID: 17267699.8: Lahti A, Sareila O, Kankaanranta H, Moilanen E. Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression. BMC Pharmacol. 2006 Feb 21;

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