1169829-40-6|Saridegib HCl|N-((2S,3R,3aR,4a'R,6R,6a'R,6b'R,7aR,12a'R,12b'S)-3,6,11',12b'-tetramethyl-2',3a,3',4,4',4a',5,5',6,6',6a',6b',7,7a,7',8',10',12',12a',12b'-icosahydro-1'H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide hydrochloride|-范德生物科技公司

Saridegib HCl

NMR下载 COA and HPLC MSDS下载
names：
N-((2S,3R,3aR,4a'R,6R,6a'R,6b'R,7aR,12a'R,12b'S)-3,6,11',12b'-tetramethyl-2',3a,3',4,4',4a',5,5',6,6',6a',6b',7,7a,7',8',10',12',12a',12b'-icosahydro-1'H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide hydrochloride
CAS号：
1169829-40-6
MDL Number：
MF(分子式)： C29H49ClN2O3S MW(分子量)： 541.23
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N-((2S,3R,3aR,4a'R,6R,6a'R,6b'R,7aR,12a'R,12b'S)-3,6,11',12b'-tetramethyl-2',3a,3',4,4',4a',5,5',6,6',6a',6b',7,7a,7',8',10',12',12a',12b'-icosahydro-1'H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide hydrochloride
英文别名	Saridegib HCl; IPI926 HCl; IPI 926 HCl; IPI-926 HCl; IPI-926 Hydrochloride; IPI926 Hydrochloride; IPI 926 Hydrochloride
CAS号	1169829-40-6
SMILES	C[C@@H](CN1)C[C@H]([C@H]1[C@H]2C)O[C@@]32CC[C@@H]4[C@@H]5CC[C@@H]6CC(NS(C)(=O)=O)CC[C@]6(C)[C@@H]5CC4=C(C)C3.Cl
Inchi	InChI=1S/C29H48N2O3S.ClH/c1-17-12-26-27(30-16-17)19(3)29(34-26)11-9-22-23-7-6-20-13-21(31-35(5,32)33)8-10-28(20,4)25(23)14-24(22)18(2)15-29;/h17,19-23,25-27,30-31H,6-16H2,1-5H3;1H/t17-,19-,20-,21?,22-,23+,25-,26-,27-,28+,29+;/m1./s1
InchiKey	LICVMCOINZNZNW-ZMLHKANGSA-N
分子式 Formula	C29H49ClN2O3S
分子量 Molecular Weight	541.23
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Saridegib HCl(CAS:1169829-40-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Saridegib HCl, also known as IPI-926 HCl, is a hedgehog pathway inhibitor which inhibits smoothened.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Neelakantan D, Zhou H, Oliphant MUJ, Zhang X, Simon LM, Henke DM, Shaw CA, Wu MF, Hilsenbeck SG, White LD, Lewis MT, Ford HL. EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun. 2017 Jun 12;8:15773. doi: 10.1038/ncomms15773. Erratum in: Nat Commun. 2018 Nov 12;9(1):4720. PubMed PMID: 28604738; PubMed Central PMCID: PMC5472791.

[2]Ma H, Tian Y, Yu X. Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models. Med Sci Monit. 2017 Mar 28;2

[3]1493-1500. PubMed PMID: 28350784; PubMed Central PMCID: PMC5381338.

[4]Lauressergues E, Heusler P, Lestienne F, Troulier D, Rauly-Lestienne I, Tourette A, Ailhaud MC, Cathala C, Tardif S, Denais-Laliève D, Calmettes MT, Degryse AD, Dumoulin A, De Vries L, Cussac D. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214. doi: 10.1002/prp2.214. eCollection 2016 Apr. PubMed PMID: 27069629; PubMed Central PMCID: PMC4804317.

[5] Bowles DW, Keysar SB, Eagles JR, Wang G, Glogowska MJ, McDermott JD, Le PN, Gao D, Ray CE, Rochon PJ, Roop DR, Tan AC, Serracino HS, Jimeno A. A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma. Oral Oncol. 2016 Feb;5

3:74-9. doi: 10.1016/j.oraloncology.2015.11.014. Epub 2015 Dec 15. PubMed PMID: 26705064; PubMed Central PMCID: PMC5676309.

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