69245-38-1|Rudolfomycin|Rudolfomycin|-范德生物科技公司

Rudolfomycin

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names：
Rudolfomycin
CAS号：
69245-38-1
MDL Number：
MF(分子式)： C42H52N2O16 MW(分子量)： 840.87
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	methyl (1R,2R,4S)-4-(((2R,4S,5S,6S)-5-(((2S,4S,5S,6S)-5-(((2R,6S)-3-amino-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-2,5,7,10-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
英文别名	Rudolfomycin; Rudolphomycin;
CAS号	69245-38-1
Inchi	InChI=1S/C42H52N2O16/c1-8-42(53)15-27(30-19(34(42)40(52)54-7)11-20-31(36(30)50)37(51)33-24(46)10-9-23(45)32(33)35(20)49)58-28-13-22(44(5)6)38(17(3)55-28)59-29-14-26(48)39(18(4)56-29)60-41-21(43)12-25(47)16(2)57-41/h9-12,16-18,22,26-29,34,38-39,41,45-46,48,50,53H,8,13-15,43H2,1-7H3/t16-,17-,18-,22-,26-,27-,28-,29-,34-,38+,39+,41-,42+/m0/s1
InchiKey	GFEWKUPUJDGEKH-WUZCFZOISA-N
分子式 Formula	C42H52N2O16
分子量 Molecular Weight	840.87
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Rudolfomycin(CAS:69245-38-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Rudolfomycin is a class II anthracycline antitumor antibiotic that inhibit the synthesis of nucleolar RNA in intact tumor cells.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Westendorf J, Marquardt H, Marquardt H. Structure-activity relationship of anthracycline-induced genotoxicity in vitro. Cancer Res. 1984 Dec;44(12 Pt 1):5599-604. PubMed PMID: 6388827.

[2]DuVernay VH, Crooke ST. Effects of several anthracycline antitumor antibiotics on the transcriptional activity of isolated nucleoli. J Antibiot (Tokyo). 1980 Sep;33(9):1048-53. PubMed PMID: 6160136.

[3] DuVernay VH Jr, Pachter JA, Crooke ST. Deoxyribonucleic acid binding studies on several new anthracycline antitumor antibiotics. Sequence preference and structure--activity relationships of marcellomycin and its analogues as compared to adriamycin. Biochemistry. 1979 Sep 4;18(18):4024-30. PubMed PMID: 486409.

[4] DuVernay VH, Essery JM, Doyle TW, Bradner WT, Crooke ST. The antitumor effects of anthracyclines. The importance of the carbomethoxy-group at position-10 of marcellomycin and rudolfomycin. Mol Pharmacol. 1979 Mar;15(2):341-56. PubMed PMID: 470932.

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