76676-34-1|RU28318 potassium|potassium 3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-7-propyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoate|-范德生物科技公司

RU28318 potassium

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names：
potassium 3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-7-propyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoate
CAS号：
76676-34-1
MDL Number：
MF(分子式)： C25H37KO4 MW(分子量)： 440.66
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	potassium 3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-7-propyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoate
英文别名	RU28318; RU 28318; RU-28318; RU 28318, potassium salt.
CAS号	76676-34-1
Inchi	InChI=1S/C25H38O4.K/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24,29)13-9-21(27)28;/h15-16,19-20,22,29H,4-14H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,19+,20+,22-,23+,24+,25+;/m1./s1
InchiKey	HXJITUGMCJCKCE-NKTBGYRQSA-M
分子式 Formula	C25H37KO4
分子量 Molecular Weight	440.66
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RU28318 potassium(CAS:76676-34-1 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RU 28318, potassium salt is a potent and selective antagonist for the mineralocorticoid receptor (MR). RU 28318, potassium salt inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. It also decreases blood pressure in female rats following central administration in vivo.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Benter IF, Babiker F, Al-Rashdan I, Yousif M, Akhtar S. RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes. J Diabetes Res. 2013;201

3:427693. doi: 10.1155/2013/427693. Epub 2013 Aug 27. PubMed PMID: 24066305; PubMed Central PMCID: PMC3771425.

[3]Kim PJ, Cole MA, Kalman BA, Spencer RL. Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J Steroid Biochem Mol Biol. 1998 Nov;67(3):213-22. PubMed PMID: 9879980.

[4]Souness GW, Morris DJ. The "mineralocorticoid-like" actions conferred on corticosterone by carbenoxolone are inhibited by the mineralocorticoid receptor (type I) antagonist RU28318. Endocrinology. 1991 Nov;129(5):2451-6. PubMed PMID: 1657575.

[5] Gómez-Sánchez EP, Fort CM, Gómez-Sánchez CE. Intracerebroventricular infusion of RU28318 blocks aldosterone-salt hypertension. Am J Physiol. 1990 Mar;258(3 Pt 1):E482-4. PubMed PMID: 2316642.

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