94162-23-9|Renin inhibitory peptide, statine|Renin inhibitory peptide, statine|-范德生物科技公司

Renin inhibitory peptide, statine

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names：
Renin inhibitory peptide, statine
CAS号：
94162-23-9
MDL Number：
MF(分子式)： C54H77N13O9 MW(分子量)： 1052.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(S)-N-((S)-1-(((S)-1-(((3S,4S)-1-(((2S,3S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl)amino)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-1-(((R)-2-amino-2-methylbutanoyl)-L-histidyl)pyrrolidine-2-carboxamide
英文别名	Renin inhibitory peptide, statine; Iva-his-pro-phe-his-sta-leu-phe-NH2; SCRIP;
CAS号	94162-23-9
Inchi	InChI=1S/C54H77N13O9/c1-7-33(5)46(51(74)62-39(47(55)70)23-34-16-11-9-12-17-34)66-45(69)27-44(68)38(22-32(3)4)61-49(72)41(25-36-28-57-30-59-36)63-48(71)40(24-35-18-13-10-14-19-35)64-50(73)43-20-15-21-67(43)52(75)42(26-37-29-58-31-60-37)65-53(76)54(6,56)8-2/h9-14,16-19,28-33,38-44,46,68H,7-8,15,20-27,56H2,1-6H3,(H2,55,70)(H,57,59)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,73)(H,65,76)(H,66,69)/t33-,38-,39-,40-,41-,42-,43-,44-,46-,54+/m0/s1
InchiKey	SZMATORSVSGBIL-IDSKXIRVSA-N
分子式 Formula	C54H77N13O9
分子量 Molecular Weight	1052.29
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Renin inhibitory peptide, statine(CAS:94162-23-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Renin inhibitory peptide, statine is a potent, specific statine -containing renin inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Blaine EH, Schorn TW, Boger J. Statine-containing renin inhibitor. Dissociation of blood pressure lowering and renin inhibition in sodium-deficient dogs. Hypertension. 1984 Mar-Apr;6(2 Pt 2):I111-8. PubMed PMID: 6373590.

[2]Hui KY, Carlson WD, Bernatowicz MS, Haber E. Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides. J Med Chem. 1987 Aug;30(8):1287-95. PubMed PMID: 3302256.

[3] Leckie BJ, Grant J, Hallett A, Hughes M, Jones DM, Szelke M, Tree M. Peptide inhibitors of renin. Scott Med J. 1984 Apr;29(2):125-6. PubMed PMID: 6397858.

[4] Veber DF, Bock MG, Brady SF, Ulm EH, Cochran DW, Smith GM, LaMont BI, Dipardo RM, Poe M, Freidinger RM, et al. Renin inhibitors containing 2-substituted statine. Biochem Soc Trans. 1984 Dec;12(6):956-9. PubMed PMID: 6442237.

[5] Blaine EH. Characteristics of the blood pressure lowering action of renin inhibition and comparison with angiotensin converting enzyme inhibition. J Hypertens Suppl. 1989 Apr;7(2):S47-9. PubMed PMID: 2666614.

6: Veber DF, Payne LS, Williams PD, Perlow DS, Lundell GF, Gould NP, Siegl PK, Sweet CS, Freidinger RM. Design and discovery in the development of long-acting renin inhibitors. Biochem Soc Trans. 1990 Dec;18(6):1291-4. PubMed PMID: 2088926.7: Sweet CS, Ludden CT, Frederick CM, Ribeiro LG. Hemodynamic effects of angiotensin and renin inhibition in dogs with acute left ventricular failure. Am J Med. 1984 Aug 20;77(2A):7-12. PubMed PMID: 6089558.8: Sweet CS, Ludden CT, Frederick CM, Bush LR, Ribeiro LG. Comparative hemodynamic effects of MK-422, a converting enzyme inhibitor, and a renin inhibitor in dogs with acute left ventricular failure. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1067-75. PubMed PMID: 6084762.

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