34167-45-8|Polymyxin D2|Polymyxin D2|-范德生物科技公司

Polymyxin D2

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names：
Polymyxin D2
CAS号：
34167-45-8
MDL Number：
MF(分子式)： C49H91N15O15 MW(分子量)： 1130.35
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N-((S)-4-amino-1-(((2S,3R)-3-hydroxy-1-(((R)-3-hydroxy-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3,12-bis((R)-1-hydroxyethyl)-15-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methylheptanamide
英文别名	Polymyxin D2;
CAS号	34167-45-8
Inchi	InChI=1S/C49H91N15O15/c1-24(2)10-8-9-11-36(69)55-29(12-17-50)43(73)63-39(28(7)68)49(79)61-35(23-65)46(76)58-33-16-21-54-47(77)37(26(5)66)62-44(74)32(15-20-53)57-40(70)31(14-19-52)59-48(78)38(27(6)67)64-45(75)34(22-25(3)4)60-41(71)30(13-18-51)56-42(33)72/h24-35,37-39,65-68H,8-23,50-53H2,1-7H3,(H,54,77)(H,55,69)(H,56,72)(H,57,70)(H,58,76)(H,59,78)(H,60,71)(H,61,79)(H,62,74)(H,63,73)(H,64,75)/t26-,27-,28-,29+,30+,31+,32+,33+,34-,35-,37+,38+,39+/m1/s1
InchiKey	AMOWTOQDROFIIR-ALESKEBOSA-N
分子式 Formula	C49H91N15O15
分子量 Molecular Weight	1130.35
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Polymyxin D2(CAS:34167-45-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Polymyxin D2 is a cationic lipopeptide antibiotic active against many species of Gram-negative bacteria.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Shaheen M, Li J, Ross AC, Vederas JC, Jensen SE. Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol. 2011 Dec 23;18(12):1640-8. doi: 10.1016/j.chembiol.2011.09.017. PubMed PMID: 22195566.

[2]Gilleland HE Jr, Conrad RS. Chemical alterations in cell envelopes of polymyxin-resistant mutants of Pseudomonas aeruginosa grown in the absence or presence of polymyxin. Antimicrob Agents Chemother. 1982 Dec;22(6):1012-6. PubMed PMID: 6297381; PubMed Central PMCID: PMC185712.

[3] Iannazzo L, Sathananthan S, Majewski H. Modulation of dopamine release from rat striatum by protein kinase C: interaction with presynaptic D2-dopamine-autoreceptors. Br J Pharmacol. 1997 Dec;122(8):1561-6. PubMed PMID: 9422799; PubMed Central PMCID: PMC1565103.

[4] Jamrozik Z, De Yebenes JG, Troung DD, Cadet J. Intrastriatal infusion of amiloride increases rotations in 6-OHDA lesioned rats and "down-regulates" D2 receptors in the striatum and 5-HT2A receptors in the cortex. Pol J Pharmacol. 1994 Sep-Oct;46(5):417-22. PubMed PMID: 7894528.

[5] Ftayeh RM, von Tiedemann A, Rudolph KW. A new selective medium for isolation of Clavibacter michiganensis subsp. michiganensis from tomato plants and seed. Phytopathology. 2011 Nov;101(11):1355-64. doi: 10.1094/PHYTO-02-11-0045. PubMed PMID: 21999159.

6: Wang JP, Hsu MF, Raung SL, Chen CC, Kuo JS, Teng CM. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):707-12. PubMed PMID: 1336574.7: Marley SB, Hadley CL, Wakelin D. Effect of genetic variation on induced neutrophilia in mice. Infect Immun. 1994 Oct;62(10):4304-9. PubMed PMID: 7927688; PubMed Central PMCID: PMC303109.8: Kato T, Shoji T. The structure of octapeptin D (studies on antibiotics from the genus Bacillus. XXVIII). J Antibiot (Tokyo). 1980 Feb;33(2):186-91. PubMed PMID: 7380727.9: Hu G, Wu YM, Jin GZ. (-)-Stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):49-52. PubMed PMID: 10072893.10: Kapotas NM. Acclimatization resistance of a Pseudomonas aeruginosa prototype strain to imipenem. J Antibiot (Tokyo). 1991 Sep;44(9):985-94. PubMed PMID: 1938622.1

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