349662-86-8|Lomaiviticin A|Lomaiviticin A|-范德生物科技公司

Lomaiviticin A

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names：
Lomaiviticin A
CAS号：
349662-86-8
MDL Number：
MF(分子式)： C68H82N6O24 MW(分子量)： 1367.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	11,11'-bis(diazo)-1,1'-bis((5-(dimethylamino)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,2'-diethyl-6,6',9,9'-tetrahydroxy-2,2'-bis((5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,2',3,3'-tetrahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]-4,4',5,5',10,10'(11H,11'H)-hexaone
英文别名	Lomaiviticin A;
CAS号	349662-86-8
Inchi	InChI=1S/C68H82N6O24/c1-13-67(97-37-20-32(80)56(74(9)10)24(4)92-37)51-46(45-48(54(51)72-70)62(86)42-30(78)18-16-28(76)40(42)60(45)84)63(87)50(66(67)96-36-21-33(89-11)57(81)25(5)93-36)52-64(88)44-43-47(61(85)41-29(77)17-15-27(75)39(41)59(43)83)53(71-69)49(44)65(95-35-19-31(79)55(73(7)8)23(3)91-35)68(52,14-2)98-38-22-34(90-12)58(82)26(6)94-38/h15-18,23-26,31-38,50,52,55-58,65-66,69-70,75-82H,13-14,19-22H2,1-12H3
InchiKey	JVXAYSMFVOJEHL-UHFFFAOYSA-N
分子式 Formula	C68H82N6O24
分子量 Molecular Weight	1367.42
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lomaiviticin A(CAS:349662-86-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lomaiviticin A is an antitumor antibiotic from Micromonospora lomaivitiensis; benzo(a)fluorene related to kinamycins.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB. The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA. Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 1[1]PubMed PMID: 24848236; PubMed Central PMCID: PMC4090708.

[2]Waldman AJ, Balskus EP. Lomaiviticin biosynthesis employs a new strategy for starter unit generation. Org Lett. 2014 Jan 17;16(2):640-3. doi: 10.1021/ol403714g. Epub 2014 Jan 2. PubMed PMID: 24383813; PubMed Central PMCID: PMC3965344.

[3] Feldman KS, Selfridge BR. Synthesis studies on the lomaiviticin A aglycone core: development of a divergent, two-directional strategy. J Org Chem. 2013 May 3;78(9):4499-511. doi: 10.1021/jo4005074. Epub 2013 Apr 15. PubMed PMID: 23581811.

[4] Woo CM, Beizer NE, Janso JE, Herzon SB. Isolation of lomaiviticins C-E, transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses. J Am Chem Soc. 2012 Sep 19;134(37):15285-8. Epub 2012 Sep 10. PubMed PMID: 22963534.

[5] Feldman KS, Selfridge BR. Enantioselective synthesis of the ent-lomaiviticin A bicyclic core. Org Lett. 2012 Nov 2;14(21):5484-7. doi: 10.1021/ol302567f. Epub 2012 Oct 17. PubMed PMID: 23075085.

6: Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB. Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. J Am Chem Soc. 2015 May 6;137(17):5741-7. doi: 10.1021/ja513117p. Epub 2015 Apr 22. PubMed PMID: 25849366; PubMed Central PMCID: PMC4845730.7: Xue M, Herzon SB. Mechanism of Nucleophilic Activation of (-)-Lomaiviticin A. J Am Chem Soc. 2016 Dec 7;138(48):15559-15562. Epub 2016 Nov 28. PubMed PMID: 27934014; PubMed Central PMCID: PMC5339879.8: Woo CM, Li Z, Paulson EK, Herzon SB. Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2851-6. doi: 10.1073/pnas.1519846113. Epub 2016 Feb 29. PubMed PMID: 26929332; PubMed Central PMCID: PMC4801295.9: Colis LC, Herzon SB. Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3122-3126. doi: 10.1016/j.bmcl.2016.04.090. Epub 2016 Apr 30. PubMed PMID: 27177826; PubMed Central PMCID: PMC4899226.10: Morris WJ, Shair MD. Synthesis of the N-(tert-butyloxycarbonyl)-O-triisopropylsilyl-D-pyrrolosamine Glycal of Lomaiviticin A

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