12710-02-0|Lienomycin|Lienomycin|-范德生物科技公司

Lienomycin

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names：
Lienomycin
CAS号：
12710-02-0
MDL Number：
MF(分子式)： C67H107NO18 MW(分子量)： 1214.58
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(5Z,7Z,9Z,11Z,13Z,19Z,23Z,35Z)-44-((1E,4R,5E,8R)-11-amino-4,8-dihydroxyundeca-1,5-dien-1-yl)-23-(but-3-en-1-yl)-16,18,30,32,34,38,40,42-octahydroxy-15,17,27-trimethyl-26-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)oxacyclotetratetraconta-5,7,9,11,13,19,23,35-octaene-2,28-dione
英文别名	Lienomycin;
CAS号	12710-02-0
Inchi	InChI=1S/C67H107NO18/c1-6-7-25-49-26-18-19-34-59(77)47(4)63(80)45(2)24-16-14-12-10-8-9-11-13-15-17-35-62(79)85-58(33-22-29-50(69)27-20-28-51(70)32-23-38-68)43-56(75)41-54(73)39-52(71)30-21-31-53(72)40-55(74)42-57(76)44-60(78)46(3)61(37-36-49)86-67-66(83)65(82)64(81)48(5)84-67/h6,8-16,19-22,24,27,31,33-34,36,45-48,50-59,61,63-67,69-77,80-83H,1,7,17-18,23,25-26,28-30,32,35,37-44,68H2,2-5H3/b10-8-,11-9-,14-12-,15-13-,24-16-,27-20+,31-21-,33-22+,34-19-,49-36-/t45?,46?,47?,48-,50-,51-,52?,53?,54?,55?,56?,57?,58?,59?,61?,63?,64-,65+,66+,67-/m0/s1
InchiKey	YUGKVAOWNQMSPU-VJQRYWHOSA-N
分子式 Formula	C67H107NO18
分子量 Molecular Weight	1214.58
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lienomycin(CAS:12710-02-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lienomycin is a pentaene macrolide antitumor antibiotic produced by Actinomyces vendargensis Struyk et Stheeman. It is a polyene with inonphore-like action.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Pawlak J, Zieliński J, Golik J, Gumieniak J, Borowski E. The structure of lienomycin, a pentaene macrolide antitumor antibiotic. I. The structure of the carbon skeleton and the location of functionalities. J Antibiot (Tokyo). 1980 Sep;33(9):989-97. PubMed PMID: 7440420.

[2]Brazhnikova MG, Kudinova MK, Lavrova MF, Borisova VN, Krugliak EB. [Isolation, purification and physico-chemical properties of antibiotic lienomycin]. Antibiotiki. 1971 Jun;16(6):483-6. Russian. PubMed PMID: 4939468.

[3] Pawlak J, Zieliński J, Golik J, Jereczek E, Borowski E. The structure of lienomycin, a pentaene macrolide antitumor antibiotic. II. The location of the pentaene chromophore and of six isolated double bonds. The complete structure of the antibiotic. J Antibiot (Tokyo). 1980 Sep;33(9):998-1004. PubMed PMID: 7440421.

[4] Belova IP. [Histopathological changes in dog kidneys following administration of lienomycin]. Antibiotiki. 1973 Jul;18(7):645-50. Russian. PubMed PMID: 4773829.

[5] Shorin VA, Rossolimo OK, Bazhanov VS, Averbukh LA, Kriàtova GA. [Study of the antineoplastic effect of lienomycin in animal experiments]. Antibiotiki. 1971;16(8):708-13. Russian. PubMed PMID: 5171847.

6: Filippos'iants ST, Gol'dberg LE, Stepanova ES. [Lienomycin effect on the kidney and liver function and on cholesterol blood levels in animals]. Antibiotiki. 1972 Jul;17(7):623-9. Russian. PubMed PMID: 4655012.7: Zieniawa T, Popinigis J, Wozniak M, Cybulska B, Borowski E. Ionophore-like action of lienomycin on energized membrane of rat-liver mitochondria. FEBS Lett. 1977 Apr 1;76(1):81-5. PubMed PMID: 67057.8: Filippos'iants ST, Gol'dberg LE, Stepanova ES, Belova IP, Kunrat IA. [Study of the toxicity and pharmacological properties of the new antibiotic lienomycin]. Antibiotiki. 1971 Jul;16(7):604-9. Russian. PubMed PMID: 5157509.9: Gauze GF, Maksimova TS, Ol'khovatova OL, Kudrina ES, Il'chenko GB. [Production of the antibiotic lienomycin in a culture of diastato chromogenes var. lienomycini]. Antibiotiki. 1971 May;16(5):387-90. Russian. PubMed PMID: 5002219.10: Shvesnikova MA, Maksimova TS, Ol'khovatova OL, Tuliakova TV, Lavrova MF. [Lienomycin production by strains of Actinomyces vendargensis Struyk et Stheeman, 1957]. Antibiotiki. 1973 Feb;18(2):102-5. Russian. PubMed PMID: 4776389.1

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