169188-19-6|L-692429 HCl|3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide hydrochloride|-范德生物科技公司

L-692429 HCl

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names：
3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide hydrochloride
CAS号：
169188-19-6
MDL Number：
MF(分子式)： C29H32ClN7O2 MW(分子量)： 546.072
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L-692429 HCl
英文别名	L-692,429; L 692,429; L692,429; L-692429; L 692429; L692429; L-692429 HCl; L-692429 Hydrochloride
CAS号	169188-19-6
Inchi	InChI=1S/C29H31N7O2.ClH/c1-29(2,30)17-26(37)31-24-16-15-21-7-3-6-10-25(21)36(28(24)38)18-19-11-13-20(14-12-19)22-8-4-5-9-23(22)27-32-34-35-33-27;/h3-14,24H,15-18,30H2,1-2H3,(H,31,37)(H,32,33,34,35);1H/t24-;/m1./s1
InchiKey	WZCMWJMQSXRZBP-GJFSDDNBSA-N
分子式 Formula	C29H32ClN7O2
分子量 Molecular Weight	546.072
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L-692429 HCl(CAS:169188-19-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L-692,429 is a novel nonpeptidyl growth hormone secretagogue.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lin P, Pisano JM, Schoen WR, Cheng K, Chan WW, Butler BS, Smith RG, Fisher MH, Wyvratt MJ. Acyclic structural variants of growth hormone secretagogue L-692,429. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3237-42. PubMed PMID: 10576695.

[2]Geris KL, Hickey GJ, Berghman LR, Visser TJ, Kühn ER, Darras VM. Pituitary and extrapituitary action sites of the novel nonpeptidyl growth hormone (GH) secretagogue L-692,429 in the chicken. Gen Comp Endocrinol. 1998 Aug;111(2):186-96. PubMed PMID: 9679090.

[3] Kirk SE, Gertz BJ, Schneider SH, Hartman ML, Pezzoli SS, Wittreich JM, Krupa DA, Seibold JR, Thorner MO. Effect of obesity and feeding on the growth hormone (GH) response to the GH secretagogue L-692,429 in young men. J Clin Endocrinol Metab. 1997 Apr;82(4):1154-9. PubMed PMID: 9100588.

[4] Cheng K, Wei L, Chaung LY, Chan WW, Butler B, Smith RG. Inhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867. J Endocrinol. 1997 Jan;152(1):155-8. PubMed PMID: 9014851.

[5] Chapman IM, Hartman ML, Pezzoli SS, Thorner MO. Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults--a clinical research center study. J Clin Endocrinol Metab. 1996 Aug;81(8):2874-80. PubMed PMID: 8768844.

6: Leung KH, Cohn DA, Miller RR, Doss GA, Stearns RA, Simpson RE, Feeney WP, Chiu SH. Pharmacokinetics and disposition of L-692,429. A novel nonpeptidyl growth hormone secretagogue in preclinical species. Drug Metab Dispos. 1996 Jul;24(7):753-60. PubMed PMID: 8818572.7: Adams EF, Petersen B, Lei T, Buchfelder M, Fahlbusch R. The growth hormone secretagogue, L-692,429, induces phosphatidylinositol hydrolysis and hormone secretion by human pituitary tumors. Biochem Biophys Res Commun. 1995 Mar 17;208(2):555-61. PubMed PMID: 7695607.8: Aloi JA, Gertz BJ, Hartman ML, Huhn WC, Pezzoli SS, Wittreich JM, Krupa DA, Thorner MO. Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects. J Clin Endocrinol Metab. 1994 Oct;79(4):943-9. PubMed PMID: 7962302.9: Gertz BJ, Sciberras DG, Yogendran L, Christie K, Bador K, Krupa D, Wittreich JM, James I. L-692,429, a nonpeptide growth hormone (GH) secretagogue, reverses glucocorticoid suppression of GH secretion. J Clin Endocrinol Metab. 1994 Sep;79(3):745-9. PubMed PMID: 8077355.10: Schoen WR, Pisano JM, Prendergast K, Wyvratt MJ Jr, Fisher MH, Cheng K, Chan WW, Butler B, Smith RG, Ball RG. A novel 3-substituted benzazepinone growth hormone secretagogue (L-692,429). J Med Chem. 1994 Apr 1;37(7):897-906. PubMed PMID: 8151616.1

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