1410935-22-6|HS665 HCl|3-[2-(Cyclobutylmethyl-phenethyl-amino)-ethyl]-phenol Hydrochloride|-范德生物科技公司

HS665 HCl

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names：
3-[2-(Cyclobutylmethyl-phenethyl-amino)-ethyl]-phenol Hydrochloride
CAS号：
1410935-22-6
MDL Number：
MF(分子式)： C21H28ClNO MW(分子量)： 345.91
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	HS665 HCl
英文别名	HS665; HS-665; HS 665; HS665 HCl;
CAS号	1410935-22-6
Inchi	InChI=1S/C21H27NO.ClH/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18;/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2;1H
InchiKey	ZRYMGDBUXKLANH-UHFFFAOYSA-N
分子式 Formula	C21H28ClNO
分子量 Molecular Weight	345.91
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	HS665 HCl(CAS:1410935-22-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	HS665 is a novel radioligand designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhu L, Cui Z, Zhu Q, Zha X, Xu Y. Novel Opioid-Receptor Agonists with Reduced Morphine-like Side Effects. Mini Rev Med Chem. 2018 Jul 16. doi: 10.2174/1389557518666180716124336. [Epub ahead of print] PubMed PMID: 30009707.

[2]Erli F, Guerrieri E, Ben Haddou T, Lantero A, Mairegger M, Schmidhammer H, Spetea M. Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. J Med Chem. 2017 Sep 14;60(17):7579-7590. doi: 10.1021/acs.jmedchem.7b00981. Epub 2017 Aug 30. PubMed PMID: 28825813; PubMed Central PMCID: PMC5601360.

[3] Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. Br J Pharmacol. 2017 Aug;174(15):2444-2456. doi: 10.1111/bph.13854. Epub 2017 Jun 27. PubMed PMID: 28494108; PubMed Central PMCID: PMC5513865.

[4] Guerrieri E, Mallareddy JR, Tóth G, Schmidhammer H, Spetea M. Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor. ACS Chem Neurosci. 2015 Mar 18;6(3):456-63. doi: 10.1021/cn5002792. Epub 2014 Dec 24. PubMed PMID: 25496417.

[5] Spetea M, Berzetei-Gurske IP, Guerrieri E, Schmidhammer H. Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. J Med Chem. 2012 Nov 26;55(22):10302-6. doi: 10.1021/jm301258w. Epub 2012 Nov 7. PubMed PMID: 23134120.

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