789488-77-3|ENMD-1068|ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist|-范德生物科技公司

ENMD-1068

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names：
ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist
CAS号：
789488-77-3
MDL Number：
MF(分子式)： C15H30ClN3O2 MW(分子量)： 319.874
EINECS:Not available Reaxys Number:No data available
Pubchem ID:9950925 Brand:BIOFOUNT

ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist 是一种新型选择性 PAR2 拮抗剂，对凝血酶介导的 PAR3 和 PAR4 信号传导没有抑制活性。

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询价

中文别名	789488-77-3;蛋白酶激活受体2拮抗剂;PAR2拮抗剂
英文别名	ENMD1068; ENMD-1068; ENMD 1068; ENMD-1068 HCl; ENMD-1068 hydrochloride;protease-activated receptor 2 anatagonist; PAR2 anatagonist
CAS号	789488-77-3
Inchi	InChI=1S/C15H29N3O2.ClH/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16;/h13H,3-12,16H2,1-2H3;1H
InchiKey	UDMQQSSIEIJEHG-UHFFFAOYSA-N
分子式 Formula	C15H30ClN3O2
分子量 Molecular Weight	319.874
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist 是一种新型选择性 PAR2 拮抗剂，对凝血酶介导的 PAR3 和 PAR4 信号传导没有抑制活性。
Introduction	ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sulaiman I, Lim JC, Soo HL, Stanslas J. Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation. Pulm Pharmacol Ther. 2016 Oct;40:52-68. doi: 10.1016/j.pupt.2016.07.005. Epub 2016 Jul 22. Review. PubMed PMID: 27453494.

[2]Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A. Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model. J Invest Dermatol. 2016 Jan;136(1):127-35. doi: 10.1038/JID.2015.363. PubMed PMID: 26763432.

[3] Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A. Skin pH is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model. J Invest Dermatol. 2015 Sep 22. doi: 10.1038/jid.2015.363. [Epub ahead of print] PubMed PMID: 26394114.

[4] Nadeem A, Alharbi NO, Vliagoftis H, Tyagi M, Ahmad SF, Sayed-Ahmed MM. Proteinase activated receptor-2-mediated dual oxidase-2 up-regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma. Immunology. 2015 Jul;145(3):391-403. doi: 10.1111/imm.12453. PubMed PMID: 25684443; PubMed Central PMCID: PMC4479538.

[5] Aoki M, Yamaguchi R, Yamamoto T, Ishimaru Y, Ono T, Sakamoto A, Narahara S, Sugiuchi H, Hirose E, Yamaguchi Y. Granulocyte-macrophage colony-stimulating factor primes interleukin-13 production by macrophages via protease-activated receptor-2. Blood Cells Mol Dis. 2015 Apr;54(4):353-9. doi: 10.1016/j.bcmd.2015.01.007. Epub 2015 Jan 17. PubMed PMID: 25633855.

6: Matos NA, Silva JF, Damasceno KA, Cassali GD, Lemos VS, Duarte ID, Klein A. Proteinase-activated receptor 2 blockade impairs CCL11- or allergen-induced eosinophil recruitment in experimental pleurisy. Eur J Pharmacol. 2014 Oct 5;740:627-33. doi: 10.1016/j.ejphar.2014.06.018. Epub 2014 Jun 24. PubMed PMID: 24972241.7: Wang Y, Lin M, Weng H, Wang X, Yang L, Liu F. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8. doi: 10.1016/j.ajog.2014.01.040. Epub 2014 Feb 1. PubMed PMID: 24495669.8: Roviezzo F, De Angelis A, De Gruttola L, Bertolino A, Sullo N, Brancaleone V, Bucci M, De Palma R, Urbanek K, D'Agostino B, Ianaro A, Sorrentino R, Cirino G. Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. Clin Sci (Lond). 2014 Apr;126(8):545-56. doi: 10.1042/CS20130272. PubMed PMID: 24131465.9: Matos NA, Silva JF, Matsui TC, Damasceno KA, Duarte ID, Lemos VS, Cassali GD, Klein A. Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2. Inflammation. 2013 Dec;36(6):1260-7. doi: 10.1007/s10753-013-9664-5. PubMed PMID: 23749157.10: Zhou J, Perelman JM, Kolosov VP, Zhou X. Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2. Mol Cell Biochem. 2013 May;377(1-2):75-85. doi: 10.1007/s11010-013-1572-3. Epub 2013 Feb 8. PubMed PMID: 23392769.1

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