110205-60-2|EM 523|EM 523|-范德生物科技公司

EM 523

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names：
EM 523
CAS号：
110205-60-2
MDL Number：
MF(分子式)： C38H67NO12 MW(分子量)： 729.949
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-11-(((2S,3R,4S,6R)-4-(ethyl(methyl)amino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-9-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one
英文别名	EM 523; EM523L; EM-523; EM523;
CAS号	110205-60-2
Inchi	InChI=1S/C38H67NO12/c1-14-26-38(11,44)31(41)21(5)29-19(3)17-37(10,51-29)33(50-35-28(40)25(39(12)15-2)16-20(4)46-35)22(6)30(23(7)34(43)48-26)49-27-18-36(9,45-13)32(42)24(8)47-27/h20-28,30-33,35,40-42,44H,14-18H2,1-13H3/t20-,21+,22+,23-,24+,25+,26-,27+,28-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InchiKey	UTTLXGDLSXWDJI-QZCZOBQCSA-N
分子式 Formula	C38H67NO12
分子量 Molecular Weight	729.949
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	EM 523(CAS:110205-60-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	EM 523 is a Gastrointestinal Agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Duan H, Jiang Y, Zhang Y, Sun D, Liu C, Huang J, Lan X, Zhou H, Chen L, Zhong H. High quantum-yield CdSexS1-x/ZnS core/shell quantum dots for warm white light-emitting diodes with good color rendering. Nanotechnology. 2013 Jul 19;24(28):28520[1]doi: 10.1088/0957-4484/24/28/28520[1]Epub 2013 Jun 20. PubMed PMID: 23787792.

[2]Ozaki K, Yogo K, Sudo H, Onoma M, Kamei K, Akima M, Koga H, Itoh Z, Omura S, Takanashi H. Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. Pharmacology. 2007;79(4):223-35. Epub 2007 Apr 5. PubMed PMID: 17426410.

[3] Takanashi H, Yogo K, Ozaki K, Koga H, Itoh Z, Omura S. In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology. 2007;79(3):137-48. Epub 2006 Dec 20. PubMed PMID: 17183187.

[4] Thielemans L, Depoortere I, Perret J, Robberecht P, Liu Y, Thijs T, Carreras C, Burgeon E, Peeters TL. Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. Epub 2005 Mar 11. PubMed PMID: 15764739.

[5] Kitazawa T, Taneike T, Ohga A. Functional characterization of neural and smooth muscle motilin receptors in the chicken proventriculus and ileum. Regul Pept. 1997 Aug 15;71(2):87-95. PubMed PMID: 9416990.

6: Ishii M, Nakamura T, Kasai F, Baba T, Takebe K. Erythromycin derivative improves gastric emptying and insulin requirement in diabetic patients with gastroparesis. Diabetes Care. 1997 Jul;20(7):1134-7. PubMed PMID: 9203450.7: Tanaka T, Mizumoto A, Haga N, Itoh Z. A new method to measure gastric emptying in conscious dogs: a validity study and effects of EM523 and L-NNA. Am J Physiol. 1997 Apr;272(4 Pt 1):G909-15. PubMed PMID: 9142925.8: Monji H, Yamaguchi M, Aoki I, Ueno H. Highly sensitive high-performance liquid chromatographic determination method for a new erythromycin derivative, EM523, and its major metabolites in human plasma and urine using post-column tris(2,2'-bipyridine) ruthenium(III) chemiluminescence detection. J Chromatogr B Biomed Sci Appl. 1997 Mar 7;690(1-2):305-13. PubMed PMID: 9106057.9: Funabashi Y, Hakoda S, Inatomi N, Koyama K, Tanida S, Harada S, Itoh Z, Omura S. Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents. J Antibiot (Tokyo). 1996 Aug;49(8):802-10. PubMed PMID: 8823514.10: Funabashi Y, Maeshiba Y, Inatomi N, Tanayama S, Harada S, Itoh Z, Omura S. Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity. J Antibiot (Tokyo). 1996 Aug;49(8):794-801. PubMed PMID: 8823513.1

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