65154-36-1|Deamido bleomycin A2|Deamido bleomycin A2|-范德生物科技公司

Deamido bleomycin A2

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names：
Deamido bleomycin A2
CAS号：
65154-36-1
MDL Number：
MF(分子式)： C55H83N16O22S3+ MW(分子量)： 1416.538
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(3-(2'-((3S,6R,7S,8S,11S)-1-(6-amino-2-((S)-3-amino-1-(((S)-2-amino-2-carboxyethyl)amino)-3-oxopropyl)-5-methylpyrimidin-4-yl)-3-((R)-(((2R,3S,4S,5S,6S)-3-(((2R,3S,4S,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)(1H-imidazol-5-yl)methyl)-7-hydroxy-11-((R)-1-hydroxyethyl)-6,8-dimethyl-1,4,9,12-tetraoxo-2,5,10,13-tetraazapentadecan-15-yl)-[2,4'-bithiazole]-4-carboxamido)propyl)dimethylsulfonium
英文别名	Deamido bleomycin A2; Deamido Bleomycin A2; Deamido Bleomycin A 2; Deamido Bleomycin A (2).
CAS号	65154-36-1
Inchi	1S/C55H82N16O22S3/c1-20-33(68-45(71-44(20)58)25(12-31(57)75)63-13-24(56)52(86)87)49(84)70-35(41(26-14-60-19-64-26)91-54-43(39(79)37(77)29(15-72)90-54)92-53-40(80)42(93-55(59)88)38(78)30(16-73)89-53)50(85)65-22(3)36(76)21(2)46(81)69-34(23(4)74)48(83)62-10-8-32-66-28(18-94-32)51-67-27(17-95-51)47(82)61-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,63,72-74,76-80H,7-13,15-16,56H2,1-6H3,(H12-,57,58,59,60,61,62,64,65,68,69,70,71,75,81,82,83,84,85,86,87,88)/p+1/t21-,22?,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40-,41-,42-,43-,53+,54?/m0/s1
InchiKey	LEWBSQHVMFJVKL-FSFWWQNWSA-O
分子式 Formula	C55H83N16O22S3+
分子量 Molecular Weight	1416.538
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Deamido bleomycin A2(CAS:65154-36-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Deamido Bleomycin A 2 is the Major Catabolite of the Antitumor Agent Bleomycin. Metabolic inactivation of the antitumor antibiotic bleomycin is be mediated exclusively via the action of bleomycin hydrolase, a cysteine proteinase that is widely distributed in nature.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
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备注

[1]Crnovcic I, Gan F, Yang D, Dong LB, Schultz PG, Shen B. Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2670-2674. doi: 10.1016/j.bmcl.2018.04.065. Epub 2018 Apr 30. PubMed PMID: 29730026.

[2]Zou Y, Fahmi NE, Vialas C, Miller GM, Hecht SM. Total synthesis of deamido bleomycin a(2), the major catabolite of the antitumor agent bleomycin. J Am Chem Soc. 2002 Aug 14;124(32):9476-88. PubMed PMID: 12167044.

[3] Pei Z, Calmels TP, Creutz CE, Sebti SM. Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells. Mol Pharmacol. 1995 Oct;48(4):676-81. PubMed PMID: 7476893.

[4] Morris G, Mistry JS, Jani JP, Mignano JE, Sebti SM, Lazo JS. Neutralization of bleomycin hydrolase by an epitope-specific antibody. Mol Pharmacol. 1992 Jul;42(1):57-62. PubMed PMID: 1378925.

[5] Jani JP, Mistry JS, Morris G, Davies P, Lazo JS, Sebti SM. In vivo circumvention of human colon carcinoma resistance to bleomycin. Cancer Res. 1992 May 15;52(10):2931-7. PubMed PMID: 1374681.

6: Mahdadi R, Kenani A, Pommery N, Pommery J, Hénichart JP, Lhermitte M. High-performance liquid chromatography assay of bleomycin in human plasma and rat hepatocytes in culture. Cancer Chemother Pharmacol. 1991;28(1):22-6. PubMed PMID: 1710176.7: Mistry JS, Sebti SM, Lazo JS. Separation of bleomycins and their deamido metabolites by high-performance cation-exchange chromatography. J Chromatogr. 1990 Aug 10;514(1):86-90. PubMed PMID: 1698802.8: Lazo JS, Braun ID, Labaree DC, Schisselbauer JC, Meandzija B, Newman RA, Kennedy KA. Characteristics of bleomycin-resistant phenotypes of human cell sublines and circumvention of bleomycin resistance by liblomycin. Cancer Res. 1989 Jan 1;49(1):185-90. PubMed PMID: 2461797.9: Seki T, Muraoka Y, Takahashi K, Horinishi H, Umezawa H. Radioimmunoassay of bleomycins. J Antibiot (Tokyo). 1985 Sep;38(9):1251-6. PubMed PMID: 2415502.10: Huang CH, Mirabelli CK, Jan Y, Crooke ST. Single-strand and double-strand deoxyribonucleic acid breaks produced by several bleomycin analogues. Biochemistry. 1981 Jan 20;20(2):233-8. PubMed PMID: 6162480.

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