111846-43-6|Dafphedyn|Dafphedyn|-范德生物科技公司

Dafphedyn

NMR下载 COA and HPLC MSDS下载
names：
Dafphedyn
CAS号：
111846-43-6
MDL Number：
MF(分子式)： C76H124F5N25O14 MW(分子量)： 1706.98
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	(S)-N-((S)-6-amino-1-(((S)-1-(((S)-1,6-diamino-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)-1-(((S)-2-(2-((R)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)propanamido)acetamido)-3-(perfluorophenyl)propanoyl)-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl)pyrrolidine-2-carboxamide
英文别名	Dafphedyn; Dynorphin amide (1-13), ala(2)-(F(5)-phe)(4)-; Dynorphin amide (1-13), alanyl(2)-(5-fluorophenylalanine)(4)-;
CAS号	111846-43-6
Inchi	InChI=1S/C76H124F5N25O14/c1-8-40(6)61(72(119)102-50(21-15-31-94-76(90)91)73(120)106-32-16-22-54(106)71(118)101-47(18-10-12-28-83)66(113)103-51(33-38(2)3)68(115)98-46(62(85)109)17-9-11-27-82)105-67(114)49(20-14-30-93-75(88)89)99-65(112)48(19-13-29-92-74(86)87)100-69(116)52(34-39(4)5)104-70(117)53(36-44-56(77)58(79)60(81)59(80)57(44)78)97-55(108)37-95-63(110)41(7)96-64(111)45(84)35-42-23-25-43(107)26-24-42/h23-26,38-41,45-54,61,107H,8-22,27-37,82-84H2,1-7H3,(H2,85,109)(H,95,110)(H,96,111)(H,97,108)(H,98,115)(H,99,112)(H,100,116)(H,101,118)(H,102,119)(H,103,113)(H,104,117)(H,105,114)(H4,86,87,92)(H4,88,89,93)(H4,90,91,94)/t40-,41+,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,61-/m0/s1
InchiKey	GONRGWUCZCUEAR-NGBXKCEBSA-N
分子式 Formula	C76H124F5N25O14
分子量 Molecular Weight	1706.98
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dafphedyn(CAS:111846-43-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is a potent analog of dynorphin 1-13. Intracerebroventricular administration of the dynorphin analog, [D-Ala2,(F5)Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by central administration of naltrexone or naloxone. Intravenous administration of 10, 25, and 50 mg/kg of DAFPHEDYN failed to induce diuresis. The increased potency of DAFPHEDYN was apparent from the failure of an equal dose of the parent compound (dynorphin 1-13) to produce diuresis and the failure of [D-Ala2]-dynorphin 1-13-NH2 to produce analgesia. Radioligand binding studies indicated the DAFPHEDYN retains the same degree of kappa selectivity as the parent compound (dynorphin 1-13) though a drop in affinity occurred. DAFPHEDYN may be of significant interest because it retains the essential pharmacology of the parent compound and exhibits marked in vivo potency.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Walker JM, Coy DH, Young EA, Baldrighi G, Siegel SF, Bowen WD, Akil H. [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN): a potent analog of dynorphin 1-13. Peptides. 1987 Sep-Oct;8(5):811-7. PubMed PMID: 2893357.

[2]Gosnell BA, Majchrzak MJ, Krahn DD. Effects of preferential delta and kappa opioid receptor agonists on the intake of hypotonic saline. Physiol Behav. 1990 Mar;47(3):601-3. PubMed PMID: 1972796.

[3] Kostrzewa RM, Brus R, Coy DH, Criswell H, Coogan PS, Kastin AJ. D-Ala2,F5Phe4-dynorphin amide, an opiate with analgesic and toxic properties. Pol J Pharmacol Pharm. 1992 Mar-Apr;44(2):109-20. PubMed PMID: 1357636.

[4] Solin AV, Lyashev AY, Lyashev YD. Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress. Bull Exp Biol Med. 2017 Jan;162(3):313-315. doi: 10.1007/s10517-017-3603-7. Epub 2017 Jan 14. PubMed PMID: 28091903.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开