96389-69-4|Crisnatol mesylate|Crisnatol mesylate|-范德生物科技公司

Crisnatol mesylate

NMR下载 COA and HPLC MSDS下载
names：
Crisnatol mesylate
CAS号：
96389-69-4
MDL Number：
MF(分子式)： C24H25NO4S MW(分子量)： 423.527
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Crisnatol mesylate
英文别名	770U-82 mesylate; BW-A-770U mesylate; 770U-82; BW-770; BW-77OU-82; BW-A-770U; Crisnatol mesylate.
CAS号	96389-69-4
Inchi	InChI=1S/C24H25NO4S/c1-24(15-26,16-29-30(2,27)28)25-14-18-13-23-19-8-4-3-7-17(19)11-12-22(23)21-10-6-5-9-20(18)21/h3-13,25-26H,14-16H2,1-2H3
InchiKey	MXEVUFSATVKQQG-UHFFFAOYSA-N
分子式 Formula	C24H25NO4S
分子量 Molecular Weight	423.527
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Crisnatol mesylate(CAS:96389-69-4 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Crisnatol, also known as BWA770U, is a potent and selective DNA intercalator with potential anticancer activity. Crisnatol entered into phase I and II clinical trials. It was discontinued now.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Villalona-Calero MA, Petit T, Kuhn J, Cobb P, Kraynak M, Eckhardt SG, Drengler R, Simmons C, Santabarbara P, Von Hoff DD, Rowinsky EK. A phase I and pharmacological study of protracted infusions of crisnatol mesylate in patients with solid malignancies. Clin Cancer Res. 1999 Nov;5(11):3369-78. PubMed PMID: 10589747.

[2]Dorr RT, Bellamy W, Liddil JD, Baker A, Bair KW. Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols. Anticancer Drug Des. 1998 Oct;13(7):825-35. PubMed PMID: 9807165.

[3] New P, Vokes E, Rogers L, Bazan C, Hohneker J, Eble M, Vilk P. Long-term response to crisnatol mesylate in patients with glioma. Invest New Drugs. 1997;15(4):343-52. PubMed PMID: 9547677.

[4] Bailey H, Kohler P, Tuttle R, Carbone PP, Hohneker JA, Clendeninn NJ, Wilding G. Phase I evaluation of 773U82-HCl in a two-hour infusion repeated daily for three days. Invest New Drugs. 1992 Nov;10(4):279-87. PubMed PMID: 1487401.

[5] Smalley RV, Goldstein D, Bulkowski D, Hannon C, Buchler D, Knudsen C, Tuttle RL. A phase II study of crisnatol mesylate in patients with ovarian carcinoma. Invest New Drugs. 1992 Jul;10(2):107-12. PubMed PMID: 1500264.

6: Hufford CD, el-Sharkawy SH, Jurgens TM, Mikell JR. Microbial production of a crisnatol metabolite. Pharm Res. 1992 May;9(5):623-5. PubMed PMID: 1608892.7: Zucker RM, Adams DJ, Bair KW, Elstein KH. An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials. Invest New Drugs. 1992 Apr;10(1):1-15. PubMed PMID: 1607248.8: Zucker RM, Adams DJ, Bair KW, Elstein KH. Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment. Biochem Pharmacol. 1991 Nov 6;42(11):2199-208. PubMed PMID: 1659821.9: Patel DK, Shockcor JP, Chang SY, Sigel CW, Huber BE. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. PubMed PMID: 1650211.10: Bair KW, Andrews CW, Tuttle RL, Knick VC, Cory M, McKee DD. 2-[(arylmethyl) amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding. J Med Chem. 1991 Jul;34(7):1983-90. PubMed PMID: 2066971.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开