1446399-26-3|Cmpd-A|N-[7-Cyano-1,1-dioxido-6-(trifluoromethyl)-2,3-dihydro-1-benzothiophen-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxyimidazo[1,2-a]pyridine-2-carboxamide|-范德生物科技公司

Cmpd-A

NMR下载 COA and HPLC MSDS下载
names：
N-[7-Cyano-1,1-dioxido-6-(trifluoromethyl)-2,3-dihydro-1-benzothiophen-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxyimidazo[1,2-a]pyridine-2-carboxamide
CAS号：
1446399-26-3
MDL Number：
MF(分子式)： C30H27F4N5O4S MW(分子量)： 629.63
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Cmpd-A
英文别名	Cmpd-A; CmpdA; Cmpd A; CENP-E inhibitor Compound-A; CENP E inhibitor Compound A; CENPE inhibitor CompoundA; CENP-E inhibitor Compound A; CENP E inhibitor Compound-A; CENPE inhibitor Compound-A
CAS号	1446399-26-3
Inchi	InChI=1S/C30H27F4N5O4S/c1-17-14-18(8-11-22(17)31)27-26(36-24-6-5-7-25(43-4)39(24)27)29(40)38(13-12-37(2)3)23-16-44(41,42)28-19(23)9-10-21(20(28)15-35)30(32,33)34/h5-11,14,23H,12-13,16H2,1-4H3/t23-/m0/s1
InchiKey	LSBPCEAYWVLUDD-QHCPKHFHSA-N
分子式 Formula	C30H27F4N5O4S
分子量 Molecular Weight	629.63
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cmpd-A(CAS:1446399-26-3 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ohashi A, Ohori M, Iwai K, Nambu T, Miyamoto M, Kawamoto T, Okaniwa M. A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity. PLoS One. 2015 Dec 9;10(12):e0144675. doi: 10.1371/journal.pone.0144675. eCollection 2015. PubMed PMID: 26649895; PubMed Central PMCID: PMC4674098.