722454-12-8|Cefilavancin|Cefilavancin|-范德生物科技公司

Cefilavancin

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names：
Cefilavancin
CAS号：
722454-12-8
MDL Number：
MF(分子式)： C87H95Cl3N16O28S2 MW(分子量)： 1983.271
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(6R,7R)-7-[[(2Z)-2-(2-amino-5-chloro-1,3-thiazol-4-yl)-2-[3-[[(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carbonyl]amino]propoxyimino]acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
英文别名	Cefilavancin; TD-1792; TD1792; TD 1792
CAS号	722454-12-8
Inchi
InchiKey	OGUAFUAJSPORAH-KHCCTVBNSA-N
分子式 Formula	C87H95Cl3N16O28S2
分子量 Molecular Weight	1983.271
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cefilavancin(CAS:722454-12-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cefilavancin is a glycopeptide-cephalosporin heterodimer antibiotic used against Gram-positive bacteria.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Stryjewski ME, Potgieter PD, Li YP, Barriere SL, Churukian A, Kingsley J, Corey GR; TD-1792 Investigators Group. TD-1792 versus vancomycin for treatment of complicated skin and skin structure infections. Antimicrob Agents Chemother. 2012 Nov;56(11):5476-83. doi: 10.1128/AAC.00712-12. Epub 2012 Aug 6. PubMed PMID: 22869571; PubMed Central PMCID: PMC3486540.

[2]Blais J, Lewis SR, Krause KM, Benton BM. Antistaphylococcal activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic. Antimicrob Agents Chemother. 2012 Mar;56(3):1584-7. doi: 10.1128/AAC.05532-11. Epub 2011 Dec 27. PubMed PMID: 22203585; PubMed Central PMCID: PMC3294951.

[3] Hegde SS, Okusanya OO, Skinner R, Shaw JP, Obedencio G, Ambrose PG, Blais J, Bhavnani SM. Pharmacodynamics of TD-1792, a novel glycopeptide-cephalosporin heterodimer antibiotic used against Gram-positive bacteria, in a neutropenic murine thigh model. Antimicrob Agents Chemother. 2012 Mar;56(3):1578-83. doi: 10.1128/AAC.05382-11. Epub 2011 Dec 12. PubMed PMID: 22155835; PubMed Central PMCID: PMC3294954.

[4] Leuthner KD, Vidaillac C, Cheung CM, Rybak MJ. In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. Antimicrob Agents Chemother. 2010 Sep;54(9):3799-803. doi: 10.1128/AAC.00452-10. Epub 2010 Jun 28. PubMed PMID: 20585126; PubMed Central PMCID: PMC2935031.

[5] Tyrrell KL, Citron DM, Warren YA, Goldstein EJ. In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species. Antimicrob Agents Chemother. 2012 Apr;56(4):2194-7. doi: 10.1128/AAC.06274-11. Epub 2012 Jan 30. PubMed PMID: 22290981; PubMed Central PMCID: PMC3318369.

6: Long DD, Aggen JB, Chinn J, Choi SK, Christensen BG, Fatheree PR, Green D, Hegde SS, Judice JK, Kaniga K, Krause KM, Leadbetter M, Linsell MS, Marquess DG, Moran EJ, Nodwell MB, Pace JL, Trapp SG, Turner SD. Exploring the positional attachment of glycopeptide/beta-lactam heterodimers. J Antibiot (Tokyo). 2008 Oct;61(10):603-14. doi: 10.1038/ja.2008.80. PubMed PMID: 19168974.7: Turner B, Murch L. Interscience Conference on Antimicrobial Agents and Chemotherapy--49th annual meeting. Part 1. 11-15 September 2009, San Francisco, CA, USA. IDrugs. 2009 Nov;12(11):667-9. PubMed PMID: 19844846.

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