121251-02-3|Bicisate (Free base)|diethyl 2,2'-(ethane-1,2-diylbis(azanediyl))(2R,2'R)-bis(3-mercaptopropanoate)|-范德生物科技公司

Bicisate (Free base)

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names：
diethyl 2,2'-(ethane-1,2-diylbis(azanediyl))(2R,2'R)-bis(3-mercaptopropanoate)
CAS号：
121251-02-3
MDL Number：
MF(分子式)： C12H24N2O4S2 MW(分子量)： 324.45
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Bicisate (Free base)
英文别名	Bicisate;
CAS号	121251-02-3
Inchi	InChI=1S/C12H24N2O4S2/c1-3-17-11(15)9(7-19)13-5-6-14-10(8-20)12(16)18-4-2/h9-10,13-14,19-20H,3-8H2,1-2H3/t9-,10-/m0/s1
InchiKey	RZQNBTMGBODDSK-UWVGGRQHSA-N
分子式 Formula	C12H24N2O4S2
分子量 Molecular Weight	324.45
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bicisate (Free base)(CAS:121251-02-3 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bicisate, also known as ethyl cysteinate dimer (ECD), presents a molecular formula os N,N'-1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester. It is usually complex with technetium Tc99m for its usage as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT). The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl and FDA-approved on November 23, 1994.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chao MY, Liu KT, Hsia YC, Liao MH, Shen LH. Direct determination of ECD in ECD Kit: a solid sample quantitation method for active pharmaceutical ingredient in drug product. J Biomed Biotechnol. 2011;2011:196238. doi: 10.1155/2011/196238. Epub 2011 Jun 9. PubMed PMID: 21687539; PubMed Central PMCID: PMC3114541.

[2]Nobili F, Koulibaly PM, Rodriguez G, Benoit M, Girtler N, Robert PH, Brugnolo A, Darcourt J. 99mTc-HMPAO and 99mTc-ECD brain uptake correlates of verbal memory in Alzheimer's disease. Q J Nucl Med Mol Imaging. 2007 Dec;51(4):357-63. PubMed PMID: 17220817.

[3] Koulibaly PM, Nobili F, Migneco O, Vitali P, Robert PH, Girtler N, Darcourt J, Rodriguez G. 99mTc-HMPAO and 99mTc-ECD perform differently in typically hypoperfused areas in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2003 Jul;30(7):1009-13. Epub 2003 May 15. PubMed PMID: 12750851.

[4] Peremans K, Audenaert K, Blanckaert P, Jacobs F, Coopman F, Verschooten F, Van Bree H, Van Heeringen C, Mertens J, Slegers G, Dierckx R. Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Dec;26(7-8):1393-404. PubMed PMID: 12502029.

[5] Otte A, Ettlin T, Fierz L, Mueller-Brand J. Parieto-occipital hypoperfusion in late whiplash syndrome: first quantitative SPET study using technetium-99m bicisate (ECD). Eur J Nucl Med. 1996 Jan;23(1):72-4. PubMed PMID: 8586106.

6: Walovitch RC, Cheesman EH, Maheu LJ, Hall KM. Studies of the retention mechanism of the brain perfusion imaging agent 99mTc-bicisate (99mTc-ECD). J Cereb Blood Flow Metab. 1994 Jan;14 Suppl 1:S4-11. PubMed PMID: 8263070.

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