71576-41-5|Aptazapine maleate|2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine maleate|-范德生物科技公司

Aptazapine maleate

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names：
2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine maleate
CAS号：
71576-41-5
MDL Number：
MF(分子式)： C20H23N3O4 MW(分子量)： 369.421
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Aptazapine maleate
英文别名	CGS 7525A; CGS-7525A; CGS7525A; Aptazapine maleate
CAS号	71576-41-5
Inchi	InChI=1S/C16H19N3.C4H4O4/c1-17-9-10-19-14-6-3-2-5-13(14)11-18-8-4-7-15(18)16(19)12-17;5-3(6)1-2-4(7)8/h2-8,16H,9-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InchiKey	JJTOHZLQMBVMPF-BTJKTKAUSA-N
分子式 Formula	C20H23N3O4
分子量 Molecular Weight	369.421
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Aptazapine maleate(CAS:71576-41-5 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Aptazapine, also known as CGS 7525A, is a tetracyclic antidepressant (TeCA) which was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been shown to act as a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Based on its pharmacological profile, aptazapine may be classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cirilli R, Orlando V, Ferretti R, Turchetto L, Silvestri R, De Martino G, LaTorre F. Direct HPLC enantioseparation of chiral aptazepine derivatives on coatedand immobilized polysaccharide-based chiral stationary phases. Chirality. 2006Aug;18(8):621-32. PubMed PMID: 16715514.

[2]Nishino S, Haak L, Shepherd H, Guilleminault C, Sakai T, Dement WC, Mignot E.Effects of central alpha-2 adrenergic compounds on canine narcolepsy, a disorderof rapid eye movement sleep. J Pharmacol Exp Ther. 1990 Jun;253(3):1145-52.PubMed PMID: 1972749.

[3] Gower AJ, Broekkamp CL, Rijk HW, Van Delft AM. Pharmacological evaluation ofin vivo tests for alpha 2-adrenoceptor blockade in the central nervous system andthe effects of the enantiomers of mianserin and its aza-analog ORG 3770. Arch IntPharmacodyn Ther. 1988 Jan-Feb;291:185-201. PubMed PMID: 2896489.

[4] Gerhardt S, Liebman JM. Self-regulation of ICSS duration: effects ofanxiogenic substances, benzodiazepine antagonists and antidepressants. PharmacolBiochem Behav. 1985 Jan;22(1):71-6. PubMed PMID: 2858109.

[5] DeHaas Vermeulen J, Thompson TA. Assay for the determination of thetetracyclic antidepressant compound aptazapine in plasma by high-performanceliquid chromatography. J Chromatogr. 1984 Mar 9;30

6:412-6. PubMed PMID: 6715482.

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