350791-64-9|Apratoxin A|Apratoxin A|-范德生物科技公司

Apratoxin A

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names：
Apratoxin A
CAS号：
350791-64-9
MDL Number：
MF(分子式)： C45H69N5O9S MW(分子量)： 856.13
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(E)-3-((S)-2-((2S,3S,5S,7S)-3,7-dihydroxy-5,8,8-trimethylnonan-2-yl)-4,5-dihydrothiazol-4-yl)-N-((2S)-1-(((2S)-1-(((4R,5S,10aS)-3,4-dimethyl-1,6-dioxooctahydro-1H-pyrrolo[2,1-c][1,4]oxazocin-5-yl)(methyl)amino)-1-oxopropan-2-yl)(methyl)amino)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)-2-methylacrylamide
英文别名	Apratoxin A;
CAS号	350791-64-9
Inchi	InChI=1S/C45H69N5O9S/c1-25(21-37(52)45(7,8)9)20-36(51)28(4)40-46-32(24-60-40)22-26(2)39(53)47-34(23-31-15-17-33(58-12)18-16-31)42(55)48(10)29(5)41(54)49(11)38-27(3)30(6)59-44(57)35-14-13-19-50(35)43(38)56/h15-18,22,25,27-30,32,34-38,51-52H,13-14,19-21,23-24H2,1-12H3,(H,47,53)/b26-22+/t25-,27-,28-,29-,30?,32-,34-,35-,36-,37-,38-/m0/s1
InchiKey	YGTAWXSDIPGVIB-QRWYZSQDSA-N
分子式 Formula	C45H69N5O9S
分子量 Molecular Weight	856.13
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Apratoxin A(CAS:350791-64-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Apratoxin A is a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Doi T. Synthesis of the biologically active natural product cyclodepsipeptides apratoxin A and its analogues. Chem Pharm Bull (Tokyo). 2014;62(8):735-43. PubMed PMID: 25087625.

[2]Huang KC, Chen Z, Jiang Y, Akare S, Kolber-Simonds D, Condon K, Agoulnik S, Tendyke K, Shen Y, Wu KM, Mathieu S, Choi HW, Zhu X, Shimizu H, Kotake Y, Gerwick WH, Uenaka T, Woodall-Jappe M, Nomoto K. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016 Jun;15(6):1208-16. doi: 10.1158/1535-7163.MCT-15-0648. Epub 2016 Mar 29. PubMed PMID: 27196783.

[3] Thornburg CC, Cowley ES, Sikorska J, Shaala LA, Ishmael JE, Youssef DT, McPhail KL. Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens. J Nat Prod. 2013 Sep 27;76(9):1781-8. doi: 10.1021/np4004992. Epub 2013 Sep 9. PubMed PMID: 24016099; PubMed Central PMCID: PMC3969888.

[4] Masuda Y, Suzuki J, Onda Y, Fujino Y, Yoshida M, Doi T. Total synthesis and conformational analysis of apratoxin C. J Org Chem. 2014 Sep 5;79(17):8000-9. doi: 10.1021/jo501130b. Epub 2014 Aug 18. PubMed PMID: 25093538.

[5] Ma D, Zou B, Cai G, Hu X, Liu JO. Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities. Chemistry. 2006 Oct 10;12(29):7615-26. PubMed PMID: 16832801.

6: Chen J, Forsyth CJ. Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12067-72. Epub 2004 Jul 1. PubMed PMID: 15231999; PubMed Central PMCID: PMC514436.7: Liu Y, Law BK, Luesch H. Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation. Mol Pharmacol. 2009 Jul;76(1):91-104. doi: 10.1124/mol.109.056085. Epub 2009 Apr 29. PubMed PMID: 19403701.8: Doi T, Numajiri Y, Munakata A, Takahashi T. Total synthesis of apratoxin A. Org Lett. 2006 Feb 2;8(3):531-4. PubMed PMID: 16435877.9: Doi T, Numajiri Y, Takahashi T, Takagi M, Shin-ya K. Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation. Chem Asian J. 2011 Jan 3;6(1):180-8. doi: 10.1002/asia.201000549. PubMed PMID: 21080404.10: Matthew S, Schupp PJ, Luesch H. Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J Nat Prod. 2008 Jun;71(6):1113-6. doi: 10.1021/np700717s. Epub 2008 May 8. PubMed PMID: 18461997.1

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