55300-30-6|Antrafenine HCl|2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl 2-[[7-(trifluoromethyl)quinolin-4-yl]amino]benzoate dihydrochloride|-范德生物科技公司

Antrafenine HCl

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names：
2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl 2-[[7-(trifluoromethyl)quinolin-4-yl]amino]benzoate dihydrochloride
CAS号：
55300-30-6
MDL Number：
MF(分子式)： C30H28Cl2F6N4O2 MW(分子量)： 661.4704
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Antrafenine HCl
英文别名	Antrafenine HCl, SL 73-033, SL-73-033; SL73-033; SL 73033, SL-73033; SL73033; Stakan, Stakane; Antrafenine hydrochloride
CAS号	55300-30-6
Inchi	InChI=1S/C30H26F6N4O2.2ClH/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27;;/h1-11,18-19H,12-17H2,(H,37,38);2*1H
InchiKey	GEZLWXYIFNEJBC-UHFFFAOYSA-N
分子式 Formula	C30H28Cl2F6N4O2
分子量 Molecular Weight	661.4704
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Antrafenine HCl(CAS:55300-30-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wang Y, Law WK, Hu JS, Lin HQ, Ip TM, Wan DC. Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening. J Chem Inf Model. 2014 Nov 24;54(11):3046-50. doi: 10.1021/ci500503b. Epub 2014 Nov 4. PubMed PMID: 25360897.

[2]Normand M, Bergua D, Bouvet JP, Cayotte JL, Gottis M. [Correlation of the cause and composition of renal calculi. Value of morphologic and infrared analysis]. Ann Biol Clin (Paris). 1989;47(1):29-34. Review. French. PubMed PMID: 2648901.

[3] Moesch C, Rince M, Raby C, Leroux-Robert C. [Identification of a metabolite of floctafenine in urinary calculi]. Ann Biol Clin (Paris). 1987;45(5):546-50. French. PubMed PMID: 2892454.

[4] Daudon M, Moesch C, Marty L, Normand M, Rince M, Leroux-Robert C, Reveillaud RJ. [Antrafenine, urinary calculi and crystalluria]. Therapie. 1986 Nov-Dec;41(6):499-504. French. PubMed PMID: 3810546.

[5] Cheymol G, Biour M, Bruneel M, Albengres E, Hamel JD. [Evaluation of a national prospective survey on the undesirable effects of glafenine, antrafenine and floctafenine]. Therapie. 1985 Jan-Feb;40(1):45-50. French. PubMed PMID: 2860731.

6: Caccia S, Conti I, Notarnicola A. In-vivo metabolism in the rat and mouse of antrafenine to 1-m-trifluoromethylphenylpiperazine. J Pharm Pharmacol. 1985 Jan;37(1):75-7. PubMed PMID: 2858538.7: Hensby CN, Maloubier A, Civier A, Shroot B, Ortonne JP. A model for studying the anti-prostaglandin activity of drugs in human skin. Br J Dermatol. 1984 Jul;111 Suppl 27:147-51. PubMed PMID: 6743546.8: Dunn CJ, Prouteau M, Delahaye M, Purcell T, Branceni D. Antrafenine: anti-inflammatory activity with respect to oedema and leucocyte infiltration in the rat. Agents Actions. 1984 Feb;14(2):296-9. PubMed PMID: 6608864.9: Caccia S, Notarnicola A, Fong MH, Benfenati E. Identification and quantitation of 1-arylpiperazines, metabolites resulting from side-chain cleavage of (4-substituted aryl-1-piperazinyl)alkyl heterocyclic derivatives in rat plasma and brain. J Chromatogr. 1984 Jan 20;28

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