70006-24-5|ABT-724 (free base)|1H-Benzimidazole, 2-((4-(2-pyridinyl)-1-piperazinyl)methyl)-|-范德生物科技公司

ABT-724 (free base)

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names：
1H-Benzimidazole, 2-((4-(2-pyridinyl)-1-piperazinyl)methyl)-
CAS号：
70006-24-5
MDL Number：
MF(分子式)： C17H19N5 MW(分子量)： 293.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	ABT-724 (free base)
英文别名	ABT-724; ABT 724; ABT724; UNII-4WV2575JWT;
CAS号	70006-24-5
SMILES	C1(CN2CCN(C3=NC=CC=C3)CC2)=NC4=CC=CC=C4N1
Inchi	InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)
InchiKey	FRPJGTNLZNXQEX-UHFFFAOYSA-N
分子式 Formula	C17H19N5
分子量 Molecular Weight	293.37
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ABT-724 (free base)(CAS:70006-24-5 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ABT-724 acts as a dopamine agonist and is selective for the D4 subtype. It was developed as a possible drug for the treatment of erectile dysfunction. It continues to be used in scientific research into the function of the D4 receptor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sanna F, Contini A, Melis MR, Argiolas A. Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male rats. Pharmacol Biochem Behav. 2015 Oct;137:110-8. doi: 10.1016/j.pbb.2015.08.012. Epub 2015 Aug 16. PubMed PMID: 26287845.

[2]Yin P, Cao AH, Yu L, Guo LJ, Sun RP, Lei GF. ABT-724 alleviated hyperactivity and spatial learning impairment in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Neurosci Lett. 2014 Sep 19;580:142-6. doi: 10.1016/j.neulet.2014.08.008. Epub 2014 Aug 12. PubMed PMID: 25128216.

[3] Koffarnus MN, Newman AH, Grundt P, Rice KC, Woods JH. Effects of selective dopaminergic compounds on a delay-discounting task. Behav Pharmacol. 2011 Aug;22(4):300-11. doi: 10.1097/FBP.0b013e3283473bcb. PubMed PMID: 21694584; PubMed Central PMCID: PMC3135665.

[4] Depoortère R, Bardin L, Rodrigues M, Abrial E, Aliaga M, Newman-Tancredi A. Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. Behav Pharmacol. 2009 Jul;20(4):303-11. doi: 10.1097/FBP.0b013e32832ec5aa. PubMed PMID: 19584712.

[5] Marona-Lewicka D, Chemel BR, Nichols DE. Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology (Berl). 2009 Apr;203(2):265-77. doi: 10.1007/s00213-008-1238-0. Epub 2008 Jul 6. PubMed PMID: 18604600.

6: Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D. Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells. Int J Neuropsychopharmacol. 2008 May;11(3):293-307. Epub 2007 Sep 26. PubMed PMID: 17897483.7: Marona-Lewicka D, Nichols DE. Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacol Biochem Behav. 2007 Oct;87(4):453-61. Epub 2007 Jun 14. PubMed PMID: 17618679.8: Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M, Miller LN, Uchic ME, Terranova MA, El-Kouhen OF, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Chang R, Martino BR, Wetter JM, Marsh KC, Martin R, Darbyshire JF, Gintant G, Hsieh GC, Moreland RB, Sullivan JP, Brioni JD, Stewart AO. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzam ide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem. 2006 Dec 14;49(25):7450-65. PubMed PMID: 17149874.9: Engstrom KM, Daanen JF, Wagaw S, Stewart AO. Gram scale synthesis of the glucuronide metabolite of ABT-724. J Org Chem. 2006 Oct 27;71(22):8378-83. PubMed PMID: 17064008.10: Boehmler W, Carr T, Thisse C, Thisse B, Canfield VA, Levenson R. D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes Brain Behav. 2007 Mar;6(2):155-66. PubMed PMID: 16764679.1

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