162763-53-3|ABT-719 HCl|(R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride|-范德生物科技公司

ABT-719 HCl

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names：
(R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride
CAS号：
162763-53-3
MDL Number：
MF(分子式)： C18H21ClFN3O3 MW(分子量)： 381.8324
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ABT-719 HCl
英文别名	ABT-719; ABT719; ABT 719; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1
CAS号	162763-53-3
SMILES	C(C1CC1)1=C2N(C=C(F)C(N3CC[C@@H](N)C3)=C2C)C(=O)C(C(O)=O)=C1.[H]Cl
Inchi	InChI=1S/C18H20FN3O3.ClH/c1-9-15-12(10-2-3-10)6-13(18(24)25)17(23)22(15)8-14(19)16(9)21-5-4-11(20)7-21;/h6,8,10-11H,2-5,7,20H2,1H3,(H,24,25);1H/t11-;/m1./s1
InchiKey	OMXXLAGAHWXLSP-RFVHGSKJSA-N
分子式 Formula	C18H21ClFN3O3
分子量 Molecular Weight	381.8324
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ABT-719 HCl(CAS:162763-53-3 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ABT-719 is a 2-pyridone antimicrobial with activity against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyelonephritis. Therapeutic ED50s for ABT-719 against these infections were equal to or up to ten-fold lower than those for ciprofloxacin, used as a reference because of similarity in mode of action. Against E. faecalis, the therapeutic ED50s for ABT-719 were 4.5-13.6 mg/kg.day for sc administration and 6.8-8.9 mg/kg.day for oral administration. ABT-719 was more potent than ciprofloxacin and vancomycin against the E. faecalis strains, which showed ciprofloxacin and vancomycin resistance covering a range of MICs.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jacoby GA, Corcoran MA, Hooper DC. Protective effect of Qnr on agents other than quinolones that target DNA gyrase. Antimicrob Agents Chemother. 2015 Nov;59(11):6689-95. doi: 10.1128/AAC.01292-15. Epub 2015 Aug 3. PubMed PMID: 26239981; PubMed Central PMCID: PMC4604369.

[2]Ma Z, Chu DT, Cooper CS, Li Q, Fung AK, Wang S, Shen LL, Flamm RK, Nilius AM, Alder JD, Meulbroek JA, Or YS. Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position. J Med Chem. 1999 Oct 7;42(20):4202-13. PubMed PMID: 10514290.

[3] Fung AK, Shen LL. The 2-pyridone antibacterial agents: 8-position modifications. Curr Pharm Des. 1999 Jul;5(7):515-43. Review. PubMed PMID: 10438895.

[4] Saiki AY, Shen LL, Chen CM, Baranowski J, Lerner CG. DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones. Antimicrob Agents Chemother. 1999 Jul;43(7):1574-7. PubMed PMID: 10390205; PubMed Central PMCID: PMC89326.

[5] Meulbroek JA, Oleksijew A, Tanaka SK, Alder JD. Efficacy of ABT-719, a 2-pyridone antimicrobial, against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyelonephritis. J Antimicrob Chemother. 1996 Oct;38(4):641-53. PubMed PMID: 8937959.

6: Li Q, Chu DT, Claiborne A, Cooper CS, Lee CM, Raye K, Berst KB, Donner P, Wang W, Hasvold L, Fung A, Ma Z, Tufano M, Flamm R, Shen LL, Baranowski J, Nilius A, Alder J, Meulbroek J, Marsh K, Crowell D, Hui Y, Seif L, Melcher LM, Plattner JJ, et al. Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents. J Med Chem. 1996 Aug 2;39(16):3070-88. PubMed PMID: 8759628.7: Hooper DC. From fluoroquinolones to 2-pyridones. Lancet. 1995 May 13;345(8959):1192-3. PubMed PMID: 7739303.8: Alder J, Clement J, Meulbroek J, Shipkowitz N, Mitten M, Jarvis K, Oleksijew A, Hutch T Sr, Paige L, Flamm B, et al. Efficacies of ABT-719 and related 2-pyridones, members of a new class of antibacterial agents, against experimental bacterial infections. Antimicrob Agents Chemother. 1995 Apr;39(4):971-5. PubMed PMID: 7786005; PubMed Central PMCID: PMC162663.9: Flamm RK, Vojtko C, Chu DT, Li Q, Beyer J, Hensey D, Ramer N, Clement JJ, Tanaka SK. In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor. Antimicrob Agents Chemother. 1995 Apr;39(4):964-70. PubMed PMID: 7786004; PubMed Central PMCID: PMC162662.

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