74842-47-0|3-O-Demethylfortimicin A|2-amino-N-((1R,2R,3R,4S,5R,6S)-4-amino-3-(((2R,3R,6R)-3-amino-6-((R)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5,6-trihydroxycyclohexyl)-N-methylacetamide|-范德生物科技公司

3-O-Demethylfortimicin A

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names：
2-amino-N-((1R,2R,3R,4S,5R,6S)-4-amino-3-(((2R,3R,6R)-3-amino-6-((R)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5,6-trihydroxycyclohexyl)-N-methylacetamide
CAS号：
74842-47-0
MDL Number：
MF(分子式)： C16H33N5O6 MW(分子量)： 391.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3-O-Demethylfortimicin A
英文别名	3-O-Demethylfortimicin A; A49759; A-49759; A 49759
CAS号	74842-47-0
Inchi	InChI=1S/C16H33N5O6/c1-6(18)8-4-3-7(19)16(26-8)27-15-10(20)12(23)13(24)11(14(15)25)21(2)9(22)5-17/h6-8,10-16,23-25H,3-5,17-20H2,1-2H3/t6-,7-,8-,10+,11-,12-,13+,14-,15-,16-/m1/s1
InchiKey
分子式 Formula	C16H33N5O6
分子量 Molecular Weight	391.47
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	3-O-Demethylfortimicin A(CAS:74842-47-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	3-O-Demethylfortimicin A is an antibiotic.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sennello LT, Wilson DS, Afarian J, Holtam LS, Norman G, Rollins DE, Tolman KG. Single-dose pharmacokinetics of 3-O-demethylfortimicin A in humans after intravenous and intramuscular administration. Antimicrob Agents Chemother. 1986 Mar;29(3):400-4. PubMed PMID: 3717941; PubMed Central PMCID: PMC180402.

[2]Tadanier J, Hallas R. 3-O-demethyl-2,3-di-epi-fortimicins and 3-O-demethyl-3-epi-fortimicins. J Antibiot (Tokyo). 1983 Mar;36(3):256-66. PubMed PMID: 6833145.

[3] Neu HC. The in-vitro activity of O-demethylfortimicin. J Antimicrob Chemother. 1983 Feb;11(2):181-5. PubMed PMID: 6833173.

[4] Jones RN, Thornsberry C, Barry AL, Packer RR, Baker CN, Badal RE. Compound A49759, the 3-O-demethyl derivative of fortimicin A: in vitro comparison with six other aminoglycoside antibiotics. Antimicrob Agents Chemother. 1980 Nov;18(5):773-9. PubMed PMID: 7447431; PubMed Central PMCID: PMC284090.

[5] Kimura ET, Tekeli S, Pratt MC, Kesterson JW, Cusick PK, Heyman IA, Majors KR. Acute, subchronic, and chronic toxicity studies with 3-O demethylfortimicin A disulfate, a new aminocyclitol antibiotic. Toxicol Appl Pharmacol. 1985 Aug;80(1):66-77. PubMed PMID: 4024109.

6: Yang CL, Tekeli S, Lehrer SB, Cusick PK, Kesterson JW. Comparative vestibular toxicity study with 3-O-demethylfortimicin A disulfate and gentamicin sulfate in cats. Drug Chem Toxicol. 1987;10(3-4):237-56. PubMed PMID: 3501364.7: Barry AL, Jones RN, Thornsberry C, Gavan TL, Gerlach EH, Sommer HM.3-0-demethyl fortimicin A: in vitro activity and interpretive zone standards for disk diffusion susceptibility tests. Eur J Clin Microbiol. 1984 Dec;3(6):531-7. PubMed PMID: 6441709.8: Serieys C, Bergogne-Bérézin E, Prokocimer P, Delcercq D. [Clinical andbacteriological study of O-demethylfortimicin A sulfate in urinary infection]. Pathol Biol (Paris). 1986 May;34(5):490-3. French. PubMed PMID: 3534728.9: Girolami RL, Stamm JM. Comparative antimicrobial activity of O-demethylfortimicin A, a derivative of fortimicin A. Antimicrob Agents Chemother. 1980 Nov;18(5):766-72. PubMed PMID: 7447430; PubMed Central PMCID: PMC284089.10: Lartey PA, Grampovnik DJ. The base catalyzed rearrangement of3-O-demethylfortimicin A. J Antibiot (Tokyo). 1980 Sep;33(9):1071-3. PubMed PMID: 7440411.1

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