72402-20-1|Z-10-Hydroxyamitriptyline|5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (Z)-|-范德生物科技公司

Z-10-Hydroxyamitriptyline

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names：
5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (Z)-
CAS号：
72402-20-1
MDL Number：
MF(分子式)： C20H23NO MW(分子量)： 293.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (Z)-
英文别名	Z-10-Hydroxyamitriptyline
CAS号	72402-20-1
Inchi	InChI=1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12-
InchiKey	GHWBJXOKAFHZAI-ATVHPVEESA-N
分子式 Formula	C20H23NO
分子量 Molecular Weight	293.41
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Z-10-Hydroxyamitriptyline(CAS:72402-20-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Z-10-Hydroxyamitriptyline
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Shimoda K, Yasuda S, Morita S, Shibasaki M, Someya T, Bertilsson L, Takahashi S. Significance of monitoring plasma levels of amitriptyline, and its hydroxylated and desmethylated metabolites in prediction of the clinical outcome of depressive state. Psychiatry Clin Neurosci. 1997 Feb;51(1):35-4[1]PubMed PMID: 9076859.

[2]Ulrich S, Isensee T, Pester U. Simultaneous determination of amitriptyline, nortriptyline and four hydroxylated metabolites in serum by capillary gas-liquid chromatography with nitrogen-phosphorus-selective detection. J Chromatogr B Biomed Appl. 1996 Oct 11;685(1):81-9. PubMed PMID: 8930756.

[3] Breyer-Pfaff U, Becher B, Nusser E, Nill K, Baier-Weber B, Zaunbrecher D, Wachsmuth H, Prox A. Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine. Xenobiotica. 1990 Jul;20(7):727-38. PubMed PMID: 2238706.

[4] Nusser E, Nill K, Breyer-Pfaff U. Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. J Chromatogr. 1990 Jun 8;528(1):163-71. PubMed PMID: 2384550.

[5] Edelbroek PM, Zitman FG, Schreuder JN, Rooymans HG, de Wolff FA. Amitriptyline metabolism in relation to antidepressive effect. Clin Pharmacol Ther. 1984 Apr;35(4):467-73. PubMed PMID: 6705444.

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