104073-72-5|YM 16638|Acetic acid, ((5-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-1,3,4-thiadiazol-2-yl)thio)-|-范德生物科技公司

YM 16638

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names：
Acetic acid, ((5-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-1,3,4-thiadiazol-2-yl)thio)-
CAS号：
104073-72-5
MDL Number：
MF(分子式)： C18H22N2O5S3 MW(分子量)： 442.563
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Acetic acid, ((5-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-1,3,4-thiadiazol-2-yl)thio)-
英文别名	YM 16638; YM-16638; YM16638.
CAS号	104073-72-5
Inchi	InChI=1S/C18H22N2O5S3/c1-3-5-13-14(7-6-12(11(2)21)16(13)24)25-8-4-9-26-17-19-20-18(28-17)27-10-15(22)23/h6-7,24H,3-5,8-10H2,1-2H3,(H,22,23)
InchiKey	RRUNJEUMTFLLDY-UHFFFAOYSA-N
分子式 Formula	C18H22N2O5S3
分子量 Molecular Weight	442.563
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	YM 16638(CAS:104073-72-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	YM 16638 is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tohda Y. [My research on asthma today and in the future]. Arerugi. 2013 Nov;62(11):1501-14. Review. Japanese. PubMed PMID: 24552761.

[2]Goto S, Shimokawa T. Effect of the hypocholesterolemic agent YM-16638 on cholesterol biosynthesis activity and apolipoprotein B secretion in HepG2 and monkey liver. Jpn J Pharmacol. 1999 Jan;79(1):75-82. PubMed PMID: 10082320.

[3] Goto S, Shimokawa T, Ugawa T, Hisamichi N, Masuyama Y, Iizumi Y, Sato N, Takenaka T, Kodama T. Species specificity in the blood cholesterol-lowering effect of YM-16638. Br J Pharmacol. 1996 May;118(1):174-8. PubMed PMID: 8733592; PubMed Central PMCID: PMC1909480.

[4] Miyata K, Kamato T, Nishida A, Takizawa K, Takeda M. Gastric mucosal protection by YM638, a novel leukotriene D4 receptor antagonist, in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):165-75. PubMed PMID: 7781686.

[5] Kobayashi K, Fukuda T, Higuchi K, Nakamura H, Arakawa T. Role of leukotrienes in indomethacin-induced mucosal damage in rats. J Clin Gastroenterol. 1993;17 Suppl [5]S11-4. PubMed PMID: 8283004.

6: Yoshikawa T, Ichikawa H, Naito Y, Kondo M. Role of leukotrienes in gastric mucosal injury induced by ischemia-reperfusion in rats. J Clin Gastroenterol. 1992;14 Suppl 1:S68-70. PubMed PMID: 1629580.7: Filep JG, Battistini B, Sirois P. Pharmacological modulation of endothelin-induced contraction of guinea-pig isolated airways and thromboxane release. Br J Pharmacol. 1991 Jul;103(3):1633-40. PubMed PMID: 1933129; PubMed Central PMCID: PMC1907823.8: Tomioka K, Jackowski JT, Abraham WM. Characterization of sulfidopeptide leukotriene responses in sheep tracheal smooth muscle in vitro. Can J Physiol Pharmacol. 1991 Jun;69(6):805-11. PubMed PMID: 1655181.9: Osada T, Goto H, Tsukamoto Y, Nakazawa S, Sugiyama S, Ozawa T. Role of leukotrienes in hydrochloric acid-induced gastric lesions in rats. Dig Dis Sci. 1990 Feb;35(2):186-92. PubMed PMID: 2105876.10: Tomioka K, Garrido R, Stevenson JS, Abraham WM. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. PubMed PMID: 2740413.1

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