1370003-76-1|YK11|methyl (E)-2-((8R,9S,10R,13S,14S,17R)-2'-methoxy-2',13-dimethyl-3-oxo-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolan]-5'-ylidene)acetate|-范德生物科技公司

YK11

NMR下载 COA and HPLC MSDS下载
names：
methyl (E)-2-((8R,9S,10R,13S,14S,17R)-2'-methoxy-2',13-dimethyl-3-oxo-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolan]-5'-ylidene)acetate
CAS号：
1370003-76-1
MDL Number：
MF(分子式)： C25H34O6 MW(分子量)： 430.541
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl (E)-2-((8R,9S,10R,13S,14S,17R)-2'-methoxy-2',13-dimethyl-3-oxo-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolan]-5'-ylidene)acetate
英文别名	YK-11; YK 11; YK11.
CAS号	1370003-76-1
SMILES	C[C@@]12[C@](/C3=C\C(OC)=O)(OC(OC)(O3)C)CC[C@@]1([H])[C@]4([H])CCC5=CC(CC[C@]5([H])[C@@]4([H])CC2)=O
Inchi	InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17-,18+,19+,20-,23-,24?,25-/m0/s1
InchiKey	KCQHQCDHFVGNMK-DEIKBOPOSA-N
分子式 Formula	C25H34O6
分子量 Molecular Weight	430.541
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	White to off-white solid powder.
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	YK11(CAS:1370003-76-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	YK-11 is a synthetic, steroidal selective androgen receptor modulator (SARM). It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR. The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y. Selective androgenreceptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblastsby follistatin expression. Biol Pharm Bull. 2013;36(9):1460-5. PubMed PMID:23995658.

[2]Kanno Y, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A,Tominaga N, Kohra S, Arizono K, Inouye Y.(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgenreceptor. Biol Pharm Bull. 2011;34(3):318-23. PubMed PMID: 21372378.

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